Usefulness of ophthalmology psychophysical test for diagnosis and monitoring support in mild Alzheimer’s disease

Usefulness of ophthalmology psychophysical test for diagnosis and monitoring support in mild Alzheimer’s disease

Purpose Alzheimer’s disease (AD) is a neurodegenerative disorder of the central nervous system characterized by cortical atrophy most pronounced in the medial temporal and posterior temporoparietal regions. The goal of the present study was to examine the visual pathway in patients with mild AD (GDS...

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Veröffentlicht in:Acta ophthalmologica (Oxford, England) England), 2014-09, Vol.92 (s253), p.0-0
Hauptverfasser: GARCIA MARTIN, ES, DE HOZ, R, ROJAS, B, RAMIREZ, AI, SALAZAR, JJ, GIL, P, YUBERO, R, TRIVINO, A, RAMIREZ, JM
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container_issue s253
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container_title Acta ophthalmologica (Oxford, England)
container_volume 92
creator GARCIA MARTIN, ES
DE HOZ, R
ROJAS, B
RAMIREZ, AI
SALAZAR, JJ
GIL, P
YUBERO, R
TRIVINO, A
RAMIREZ, JM
description Purpose Alzheimer’s disease (AD) is a neurodegenerative disorder of the central nervous system characterized by cortical atrophy most pronounced in the medial temporal and posterior temporoparietal regions. The goal of the present study was to examine the visual pathway in patients with mild AD (GDS 4) by means of a different psychophysical test, specifically —visual acuity (VA), contrast sensitivity (CS), colour perception and perception digital test (PDT)— and to compare them with an age‐matched control. Methods Twenty‐three patients with mild AD and 27 controls were examined at Hospital Clínico San Carlos in Madrid (Spain). Subjects underwent a complete ophthalmological examination (VA, refraction, colour test, biomicroscopy, IOP, dilated fundoscopy, and OCT). Results In comparison with the control group, patients with mild AD presented a significant decrease in the VA, in the CS (for all the spatial frequencies), in the colour perception (unspecific errors blue axis) and PDT (p
doi_str_mv 10.1111/j.1755-3768.2014.3675.x
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The goal of the present study was to examine the visual pathway in patients with mild AD (GDS 4) by means of a different psychophysical test, specifically —visual acuity (VA), contrast sensitivity (CS), colour perception and perception digital test (PDT)— and to compare them with an age‐matched control. Methods Twenty‐three patients with mild AD and 27 controls were examined at Hospital Clínico San Carlos in Madrid (Spain). Subjects underwent a complete ophthalmological examination (VA, refraction, colour test, biomicroscopy, IOP, dilated fundoscopy, and OCT). Results In comparison with the control group, patients with mild AD presented a significant decrease in the VA, in the CS (for all the spatial frequencies), in the colour perception (unspecific errors blue axis) and PDT (p &lt;0.05 in all instances). Conclusion In mild AD, there are alterations in the M, P, and K visual pathways. The psychophysical ophthalmological tests used in this study could serve as a tool for AD diagnosis and follow‐up. (Support: OFTARED (Grant RD12/0034/0002, ISCIII, Spanish Ministry of Science and Innovation)</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/j.1755-3768.2014.3675.x</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Ophthalmology</subject><ispartof>Acta ophthalmologica (Oxford, England), 2014-09, Vol.92 (s253), p.0-0</ispartof><rights>2014 Acta Ophthalmologica</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1755-3768.2014.3675.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45575,46833</link.rule.ids></links><search><creatorcontrib>GARCIA MARTIN, ES</creatorcontrib><creatorcontrib>DE HOZ, R</creatorcontrib><creatorcontrib>ROJAS, B</creatorcontrib><creatorcontrib>RAMIREZ, AI</creatorcontrib><creatorcontrib>SALAZAR, JJ</creatorcontrib><creatorcontrib>GIL, P</creatorcontrib><creatorcontrib>YUBERO, R</creatorcontrib><creatorcontrib>TRIVINO, A</creatorcontrib><creatorcontrib>RAMIREZ, JM</creatorcontrib><title>Usefulness of ophthalmology psychophysical test for diagnosis and monitoring support in mild Alzheimer’s disease</title><title>Acta ophthalmologica (Oxford, England)</title><description>Purpose Alzheimer’s disease (AD) is a neurodegenerative disorder of the central nervous system characterized by cortical atrophy most pronounced in the medial temporal and posterior temporoparietal regions. The goal of the present study was to examine the visual pathway in patients with mild AD (GDS 4) by means of a different psychophysical test, specifically —visual acuity (VA), contrast sensitivity (CS), colour perception and perception digital test (PDT)— and to compare them with an age‐matched control. Methods Twenty‐three patients with mild AD and 27 controls were examined at Hospital Clínico San Carlos in Madrid (Spain). Subjects underwent a complete ophthalmological examination (VA, refraction, colour test, biomicroscopy, IOP, dilated fundoscopy, and OCT). Results In comparison with the control group, patients with mild AD presented a significant decrease in the VA, in the CS (for all the spatial frequencies), in the colour perception (unspecific errors blue axis) and PDT (p &lt;0.05 in all instances). Conclusion In mild AD, there are alterations in the M, P, and K visual pathways. The psychophysical ophthalmological tests used in this study could serve as a tool for AD diagnosis and follow‐up. 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The goal of the present study was to examine the visual pathway in patients with mild AD (GDS 4) by means of a different psychophysical test, specifically —visual acuity (VA), contrast sensitivity (CS), colour perception and perception digital test (PDT)— and to compare them with an age‐matched control. Methods Twenty‐three patients with mild AD and 27 controls were examined at Hospital Clínico San Carlos in Madrid (Spain). Subjects underwent a complete ophthalmological examination (VA, refraction, colour test, biomicroscopy, IOP, dilated fundoscopy, and OCT). Results In comparison with the control group, patients with mild AD presented a significant decrease in the VA, in the CS (for all the spatial frequencies), in the colour perception (unspecific errors blue axis) and PDT (p &lt;0.05 in all instances). Conclusion In mild AD, there are alterations in the M, P, and K visual pathways. The psychophysical ophthalmological tests used in this study could serve as a tool for AD diagnosis and follow‐up. (Support: OFTARED (Grant RD12/0034/0002, ISCIII, Spanish Ministry of Science and Innovation)</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1111/j.1755-3768.2014.3675.x</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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title Usefulness of ophthalmology psychophysical test for diagnosis and monitoring support in mild Alzheimer’s disease
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