Simplified Acute Physiology Score II/Acute Physiology and Chronic Health Evaluation II and Prediction of the Mortality and Later Development of Complications in Poisoned Patients Admitted to Intensive Care Unit

We aimed to determine the acute physiology and chronic health evaluation (APACHE) II and simplified acute physiology score (SAPS) II in poisoned patients admitted to the poisoning ICU and compare them to see which is a more sensitive and specific system for prognostication of the mortality and compl...

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Veröffentlicht in:Basic & clinical pharmacology & toxicology 2014-09, Vol.115 (3), p.297-300
Hauptverfasser: Alizadeh, Afshin Mohammad, Hassanian‐Moghaddam, Hossein, Shadnia, Shahin, Zamani, Nasim, Mehrpour, Omid
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container_issue 3
container_start_page 297
container_title Basic & clinical pharmacology & toxicology
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creator Alizadeh, Afshin Mohammad
Hassanian‐Moghaddam, Hossein
Shadnia, Shahin
Zamani, Nasim
Mehrpour, Omid
description We aimed to determine the acute physiology and chronic health evaluation (APACHE) II and simplified acute physiology score (SAPS) II in poisoned patients admitted to the poisoning ICU and compare them to see which is a more sensitive and specific system for prognostication of the mortality and complications in these patients. Between February 2013 and July 2013, all patients referring to our centre with any poisoning mandating ICU admission were prospectively included. On ICU arrival, a questionnaire containing the demographic data, parameters of the APACHE II and SAPS II scores, the sum of the scores, complications during the stay and the patients' final outcome (compete recovery versus death) was filled for every single patient. A total of 195 patients were evaluated. Forty‐two patients (21.5%) died. Mean SAPS and APACHE scores were 41 ± 16 and 15 ± 6, respectively. Mean SAPS and APACHE scores were significantly different between the survivors and non‐survivors. Both scores could successfully prognosticate the development of the complications (p = 0.07 and 0.013, respectively). APACHE II was a better score in prediction of both mortality and later complications in the setting of poisoning ICU. APACHE >22 has a good specificity in determining the mortality and development of further complications in poisoned patients admitted to the medical toxicology ICUs. SAPS II score >59 and >43 can predict the risk of mortality and later complications in these patients, as well.
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Drug treatments</topic><topic>Poisoning - mortality</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Surveys and Questionnaires</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alizadeh, Afshin Mohammad</creatorcontrib><creatorcontrib>Hassanian‐Moghaddam, Hossein</creatorcontrib><creatorcontrib>Shadnia, Shahin</creatorcontrib><creatorcontrib>Zamani, Nasim</creatorcontrib><creatorcontrib>Mehrpour, Omid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Basic &amp; clinical pharmacology &amp; toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alizadeh, Afshin Mohammad</au><au>Hassanian‐Moghaddam, Hossein</au><au>Shadnia, Shahin</au><au>Zamani, Nasim</au><au>Mehrpour, Omid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simplified Acute Physiology Score II/Acute Physiology and Chronic Health Evaluation II and Prediction of the Mortality and Later Development of Complications in Poisoned Patients Admitted to Intensive Care Unit</atitle><jtitle>Basic &amp; clinical pharmacology &amp; toxicology</jtitle><addtitle>Basic Clin Pharmacol Toxicol</addtitle><date>2014-09</date><risdate>2014</risdate><volume>115</volume><issue>3</issue><spage>297</spage><epage>300</epage><pages>297-300</pages><issn>1742-7835</issn><eissn>1742-7843</eissn><abstract>We aimed to determine the acute physiology and chronic health evaluation (APACHE) II and simplified acute physiology score (SAPS) II in poisoned patients admitted to the poisoning ICU and compare them to see which is a more sensitive and specific system for prognostication of the mortality and complications in these patients. Between February 2013 and July 2013, all patients referring to our centre with any poisoning mandating ICU admission were prospectively included. On ICU arrival, a questionnaire containing the demographic data, parameters of the APACHE II and SAPS II scores, the sum of the scores, complications during the stay and the patients' final outcome (compete recovery versus death) was filled for every single patient. A total of 195 patients were evaluated. Forty‐two patients (21.5%) died. Mean SAPS and APACHE scores were 41 ± 16 and 15 ± 6, respectively. Mean SAPS and APACHE scores were significantly different between the survivors and non‐survivors. Both scores could successfully prognosticate the development of the complications (p = 0.07 and 0.013, respectively). APACHE II was a better score in prediction of both mortality and later complications in the setting of poisoning ICU. APACHE &gt;22 has a good specificity in determining the mortality and development of further complications in poisoned patients admitted to the medical toxicology ICUs. SAPS II score &gt;59 and &gt;43 can predict the risk of mortality and later complications in these patients, as well.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>24517530</pmid><doi>10.1111/bcpt.12210</doi><tpages>4</tpages></addata></record>
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source MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection
subjects Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
APACHE
Biological and medical sciences
Child
Drug-Related Side Effects and Adverse Reactions - mortality
Female
Hospitalization
Humans
Intensive Care Units
Iran
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Poisoning - mortality
Prospective Studies
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Surveys and Questionnaires
Young Adult
title Simplified Acute Physiology Score II/Acute Physiology and Chronic Health Evaluation II and Prediction of the Mortality and Later Development of Complications in Poisoned Patients Admitted to Intensive Care Unit
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