Simplified Acute Physiology Score II/Acute Physiology and Chronic Health Evaluation II and Prediction of the Mortality and Later Development of Complications in Poisoned Patients Admitted to Intensive Care Unit
We aimed to determine the acute physiology and chronic health evaluation (APACHE) II and simplified acute physiology score (SAPS) II in poisoned patients admitted to the poisoning ICU and compare them to see which is a more sensitive and specific system for prognostication of the mortality and compl...
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Veröffentlicht in: | Basic & clinical pharmacology & toxicology 2014-09, Vol.115 (3), p.297-300 |
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creator | Alizadeh, Afshin Mohammad Hassanian‐Moghaddam, Hossein Shadnia, Shahin Zamani, Nasim Mehrpour, Omid |
description | We aimed to determine the acute physiology and chronic health evaluation (APACHE) II and simplified acute physiology score (SAPS) II in poisoned patients admitted to the poisoning ICU and compare them to see which is a more sensitive and specific system for prognostication of the mortality and complications in these patients. Between February 2013 and July 2013, all patients referring to our centre with any poisoning mandating ICU admission were prospectively included. On ICU arrival, a questionnaire containing the demographic data, parameters of the APACHE II and SAPS II scores, the sum of the scores, complications during the stay and the patients' final outcome (compete recovery versus death) was filled for every single patient. A total of 195 patients were evaluated. Forty‐two patients (21.5%) died. Mean SAPS and APACHE scores were 41 ± 16 and 15 ± 6, respectively. Mean SAPS and APACHE scores were significantly different between the survivors and non‐survivors. Both scores could successfully prognosticate the development of the complications (p = 0.07 and 0.013, respectively). APACHE II was a better score in prediction of both mortality and later complications in the setting of poisoning ICU. APACHE >22 has a good specificity in determining the mortality and development of further complications in poisoned patients admitted to the medical toxicology ICUs. SAPS II score >59 and >43 can predict the risk of mortality and later complications in these patients, as well. |
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Between February 2013 and July 2013, all patients referring to our centre with any poisoning mandating ICU admission were prospectively included. On ICU arrival, a questionnaire containing the demographic data, parameters of the APACHE II and SAPS II scores, the sum of the scores, complications during the stay and the patients' final outcome (compete recovery versus death) was filled for every single patient. A total of 195 patients were evaluated. Forty‐two patients (21.5%) died. Mean SAPS and APACHE scores were 41 ± 16 and 15 ± 6, respectively. Mean SAPS and APACHE scores were significantly different between the survivors and non‐survivors. Both scores could successfully prognosticate the development of the complications (p = 0.07 and 0.013, respectively). APACHE II was a better score in prediction of both mortality and later complications in the setting of poisoning ICU. APACHE >22 has a good specificity in determining the mortality and development of further complications in poisoned patients admitted to the medical toxicology ICUs. SAPS II score >59 and >43 can predict the risk of mortality and later complications in these patients, as well.</description><identifier>ISSN: 1742-7835</identifier><identifier>EISSN: 1742-7843</identifier><identifier>DOI: 10.1111/bcpt.12210</identifier><identifier>PMID: 24517530</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; APACHE ; Biological and medical sciences ; Child ; Drug-Related Side Effects and Adverse Reactions - mortality ; Female ; Hospitalization ; Humans ; Intensive Care Units ; Iran ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Poisoning - mortality ; Prospective Studies ; Risk Assessment ; Sensitivity and Specificity ; Severity of Illness Index ; Surveys and Questionnaires ; Young Adult</subject><ispartof>Basic & clinical pharmacology & toxicology, 2014-09, Vol.115 (3), p.297-300</ispartof><rights>2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society)</rights><rights>2015 INIST-CNRS</rights><rights>2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).</rights><rights>Copyright © 2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). 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Between February 2013 and July 2013, all patients referring to our centre with any poisoning mandating ICU admission were prospectively included. On ICU arrival, a questionnaire containing the demographic data, parameters of the APACHE II and SAPS II scores, the sum of the scores, complications during the stay and the patients' final outcome (compete recovery versus death) was filled for every single patient. A total of 195 patients were evaluated. Forty‐two patients (21.5%) died. Mean SAPS and APACHE scores were 41 ± 16 and 15 ± 6, respectively. Mean SAPS and APACHE scores were significantly different between the survivors and non‐survivors. Both scores could successfully prognosticate the development of the complications (p = 0.07 and 0.013, respectively). APACHE II was a better score in prediction of both mortality and later complications in the setting of poisoning ICU. APACHE >22 has a good specificity in determining the mortality and development of further complications in poisoned patients admitted to the medical toxicology ICUs. SAPS II score >59 and >43 can predict the risk of mortality and later complications in these patients, as well.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>APACHE</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Drug-Related Side Effects and Adverse Reactions - mortality</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Intensive Care Units</subject><subject>Iran</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Poisoning - mortality</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Surveys and Questionnaires</subject><subject>Young Adult</subject><issn>1742-7835</issn><issn>1742-7843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu3CAYhK2qUZOmvfQBKqSql0qbgDEGHzdu2qy0US0lOVsY_-4S2eAC3mpfs09Udr1ND5HCBTR8zD9ikuQDwRckrstGjeGCpCnBr5IzwrN0wUVGXz-dKTtN3nr_iHHKM4LfJKdpxghnFJ8lf-70MPa609CipZoCoGqz89r29ucO3SnrAK1Wl89upGlRuXHWaIVuQPZhg663sp9k0NbEFwegctBqdVBsh8IG0K11QfY6zAZrGcChr7CF3o4DmLDHSrvPow5GHmmDKqu9NTFeFbUIebRsBx1CVIJFKxPAeL0FVMqY9cHo8C456WTv4f1xP08evl3flzeL9Y_vq3K5XqiMcbxohJCSFTyXQlDIcyWZbBkvOowVoQVnTdaqomBU8fhXnBdF1-ZCNV0DuFOY0vPk0-w7OvtrAh_qRzs5E0fWhDGaClZQEakvM6Wc9d5BV49OD9LtaoLrfX31vr76UF-EPx4tp2aA9gn911cEPh8B6ZXsOyeN0v4_J3JRYMwjR2but-5h98LI-qqs7ufhfwFx9LVb</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Alizadeh, Afshin Mohammad</creator><creator>Hassanian‐Moghaddam, Hossein</creator><creator>Shadnia, Shahin</creator><creator>Zamani, Nasim</creator><creator>Mehrpour, Omid</creator><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201409</creationdate><title>Simplified Acute Physiology Score II/Acute Physiology and Chronic Health Evaluation II and Prediction of the Mortality and Later Development of Complications in Poisoned Patients Admitted to Intensive Care Unit</title><author>Alizadeh, Afshin Mohammad ; Hassanian‐Moghaddam, Hossein ; Shadnia, Shahin ; Zamani, Nasim ; Mehrpour, Omid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4570-b88aa5976a883e66ca5ad579f00c13975b4dc9953c71757799fd68cbfbe0fc033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>APACHE</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Drug-Related Side Effects and Adverse Reactions - mortality</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Intensive Care Units</topic><topic>Iran</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Poisoning - mortality</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Surveys and Questionnaires</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alizadeh, Afshin Mohammad</creatorcontrib><creatorcontrib>Hassanian‐Moghaddam, Hossein</creatorcontrib><creatorcontrib>Shadnia, Shahin</creatorcontrib><creatorcontrib>Zamani, Nasim</creatorcontrib><creatorcontrib>Mehrpour, Omid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Basic & clinical pharmacology & toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alizadeh, Afshin Mohammad</au><au>Hassanian‐Moghaddam, Hossein</au><au>Shadnia, Shahin</au><au>Zamani, Nasim</au><au>Mehrpour, Omid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simplified Acute Physiology Score II/Acute Physiology and Chronic Health Evaluation II and Prediction of the Mortality and Later Development of Complications in Poisoned Patients Admitted to Intensive Care Unit</atitle><jtitle>Basic & clinical pharmacology & toxicology</jtitle><addtitle>Basic Clin Pharmacol Toxicol</addtitle><date>2014-09</date><risdate>2014</risdate><volume>115</volume><issue>3</issue><spage>297</spage><epage>300</epage><pages>297-300</pages><issn>1742-7835</issn><eissn>1742-7843</eissn><abstract>We aimed to determine the acute physiology and chronic health evaluation (APACHE) II and simplified acute physiology score (SAPS) II in poisoned patients admitted to the poisoning ICU and compare them to see which is a more sensitive and specific system for prognostication of the mortality and complications in these patients. Between February 2013 and July 2013, all patients referring to our centre with any poisoning mandating ICU admission were prospectively included. On ICU arrival, a questionnaire containing the demographic data, parameters of the APACHE II and SAPS II scores, the sum of the scores, complications during the stay and the patients' final outcome (compete recovery versus death) was filled for every single patient. A total of 195 patients were evaluated. Forty‐two patients (21.5%) died. Mean SAPS and APACHE scores were 41 ± 16 and 15 ± 6, respectively. Mean SAPS and APACHE scores were significantly different between the survivors and non‐survivors. Both scores could successfully prognosticate the development of the complications (p = 0.07 and 0.013, respectively). APACHE II was a better score in prediction of both mortality and later complications in the setting of poisoning ICU. APACHE >22 has a good specificity in determining the mortality and development of further complications in poisoned patients admitted to the medical toxicology ICUs. SAPS II score >59 and >43 can predict the risk of mortality and later complications in these patients, as well.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>24517530</pmid><doi>10.1111/bcpt.12210</doi><tpages>4</tpages></addata></record> |
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subjects | Acute Disease Adolescent Adult Aged Aged, 80 and over APACHE Biological and medical sciences Child Drug-Related Side Effects and Adverse Reactions - mortality Female Hospitalization Humans Intensive Care Units Iran Male Medical sciences Middle Aged Pharmacology. Drug treatments Poisoning - mortality Prospective Studies Risk Assessment Sensitivity and Specificity Severity of Illness Index Surveys and Questionnaires Young Adult |
title | Simplified Acute Physiology Score II/Acute Physiology and Chronic Health Evaluation II and Prediction of the Mortality and Later Development of Complications in Poisoned Patients Admitted to Intensive Care Unit |
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