Androgen receptor (AR) suppresses normal human prostate epithelial cell proliferation via AR/[beta]-catenin/TCF-4 complex inhibition of c-MYC transcription

INTRODUCTION Physiologic testosterone continuously stimulates prostate stromal cell secretion of paracrine growth factors (PGFs), which if unopposed would induce hyperplastic overgrowth of normal prostate epithelial cells (PrECs). METHODS Lentiviral shRNA stable knock down of c-MYC, [beta]-catenin,...

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Veröffentlicht in:	The Prostate 2014-08, Vol.74 (11), p.1118
Hauptverfasser:	Antony, Lizamma, van der Schoor, Freek, Dalrymple, Susan L, Isaacs, John T
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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