Nutlin-3 inhibits epithelial-mesenchymal transition by interfering with canonical transforming growth factor-[beta]1-Smad-Snail/Slug axis

Enormous efforts have been made to explore small molecules that interfere with the TGF-β signaling pathway, so as to inhibit EMT and the cancer metastasis, but few agents have been identified. In this study, we demonstrated that Nutlin-3 could abolish the down-regulation of E-cadherin induced by TGF...

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Veröffentlicht in:	Cancer letters 2014-01, Vol.342 (1), p.82
Hauptverfasser:	Wu, Yeping, Fu, Yingying, Zheng, Lin, Lin, Guanyu, Ma, Jian, Lou, Jianshu, Zhu, Hong, He, Qiaojun, Yang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell adhesion & migration Cytotoxicity Drug resistance Kinases Metastasis Motility Phosphorylation Proteins Studies Tumors
Online-Zugang:	Volltext
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