Effect of opicapone and entacapone upon levodopa pharmacokinetics during three daily levodopa administrations

Background and objectives Opicapone is a novel third generation catechol- O -methyltransferase (COMT) inhibitor. The purpose of this study was to compare the levodopa pharmacokinetic profile throughout a day driven by the COMT inhibition either following repeated doses of opicapone or concomitant ad...

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Veröffentlicht in:	European journal of clinical pharmacology 2014-09, Vol.70 (9), p.1059-1071
Hauptverfasser:	Rocha, José-Francisco, Falcão, Amílcar, Santos, Ana, Pinto, Roberto, Lopes, Nelson, Nunes, Teresa, Wright, Lyndon C., Vaz-da-Silva, Manuel, Soares-da-Silva, Patrício
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiparkinson Agents - adverse effects Antiparkinson Agents - blood Antiparkinson Agents - pharmacokinetics Antiparkinson Agents - pharmacology Area Under Curve Biological and medical sciences Biomedical and Life Sciences Biomedicine Catechol O-Methyltransferase - metabolism Catechol O-Methyltransferase Inhibitors - adverse effects Catechol O-Methyltransferase Inhibitors - pharmacology Catechols - adverse effects Catechols - pharmacology Double-Blind Method Drug Administration Schedule Drug Interactions Female Humans Inhibitor drugs Levodopa - administration & dosage Levodopa - adverse effects Levodopa - blood Levodopa - pharmacokinetics Male Medical sciences Middle Aged Nitriles - adverse effects Nitriles - pharmacology Oxadiazoles - adverse effects Oxadiazoles - pharmacology Parkinson's disease Pharmacodynamics Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Young Adult
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