Stromal response to Hedgehog signaling restrains pancreatic cancer progression

Pancreatic ductal adenocarcinoma (PDA) is the most lethal of common human malignancies, with no truly effective therapies for advanced disease. Preclinical studies have suggested a therapeutic benefit of targeting the Hedgehog (Hh) signaling pathway, which is activated throughout the course of PDA p...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-07, Vol.111 (30), p.E3091-E3100
Hauptverfasser:	Lee, John J, Perera, Rushika M, Wang, Huaijun, Wu, Dai-Chen, Liu, X Shawn, Han, Shiwei, Fitamant, Julien, Jones, Phillip D, Ghanta, Krishna S, Kawano, Sally, Nagle, Julia M, Deshpande, Vikram, Boucher, Yves, Kato, Tomoyo, Chen, James K, Willmann, Jürgen K, Bardeesy, Nabeel, Beachy, Philip A
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma agonists animal models Animals Biological Sciences carcinogenesis Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology clinical trials epithelium fibroblasts Genetic engineering Hedgehog Proteins - antagonists & inhibitors Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Humans hyperplasia ligands Mice Mice, Knockout Molecules Pancreatic cancer pancreatic neoplasms Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pharmacology PNAS Plus Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Rodents Signal Transduction
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