Therapeutic targeting of microRNAs: current status and future challenges

Key Points MicroRNAs (miRNAs) have important roles in many aspects of human diseases, and their targeted inhibition may have substantial therapeutic impact. Inhibition of miRNAs can be achieved through a variety of methods and chemically modified antisense oligonucleotides (anti-miRs) have shown the...

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Veröffentlicht in:	Nature reviews. Drug discovery 2014-08, Vol.13 (8), p.622-638
Hauptverfasser:	Li, Zhonghan, Rana, Tariq M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/51/391/2310 631/337/384/331 692/699/255 692/699/67 692/699/75 Animals Antisense RNA Biomedicine Biotechnology Cancer Research Drug Delivery Systems Drug Discovery Genetic regulation Genetic research Humans Medicinal Chemistry MicroRNAs - biosynthesis MicroRNAs - drug effects MicroRNAs - physiology Molecular Medicine Pharmacology/Toxicology Properties review-article RNA Interference - drug effects RNA Interference - physiology
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