Association ofCXCR1polymorphisms with apoptosis, necrosis and concentration of milk neutrophils in early lactating dairy heifers
Associations between polymorphisms in the candidate geneCXCR1, encoding the chemokine (C-X-C motif) receptor 1, and udder health have been identified before. In the present study, associations between theCXCR1genotype (whole coding region) and apoptosis, necrosis, and concentration of milk polymorph...
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| Veröffentlicht in: | Research in veterinary science 2014-08, Vol.97 (1), p.55 |
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| creator | Verbeke, Joren Piepers, Sofie Peelman, Luc van Poucke, Mario De Vliegher, Sarne |
| description | Associations between polymorphisms in the candidate geneCXCR1, encoding the chemokine (C-X-C motif) receptor 1, and udder health have been identified before. In the present study, associations between theCXCR1genotype (whole coding region) and apoptosis, necrosis, and concentration of milk polymorphonuclear neutrophilic leukocyte (PMNL) of 292 quarters belonging to 73 early lactating dairy heifers were studied. In uninfected quarters, % milk PMNL apoptosis was higher in c.980GG heifers [least squares means (LSM) 27%] compared to c.980AG heifers (LSM 16%), whereas in infected quarters, % milk PMNL apoptosis was higher in c.642GG heifers (LSM 29%) compared to c.642AG heifers (LSM 18%). Differences in milk PMNL concentration between infected and uninfected quarters were smaller in c.980AG heifers than in c.980GG heifers. An association between theCXCR1genotype and necrosis of milk PMNL could not be demonstrated. Results indicate thatCXCR1polymorphisms influence viability and concentration of milk PMNL and provide a foundation for future research. |
| doi_str_mv | 10.1016/j.rvsc.2014.05.008 |
| format | Article |
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In the present study, associations between theCXCR1genotype (whole coding region) and apoptosis, necrosis, and concentration of milk polymorphonuclear neutrophilic leukocyte (PMNL) of 292 quarters belonging to 73 early lactating dairy heifers were studied. In uninfected quarters, % milk PMNL apoptosis was higher in c.980GG heifers [least squares means (LSM) 27%] compared to c.980AG heifers (LSM 16%), whereas in infected quarters, % milk PMNL apoptosis was higher in c.642GG heifers (LSM 29%) compared to c.642AG heifers (LSM 18%). Differences in milk PMNL concentration between infected and uninfected quarters were smaller in c.980AG heifers than in c.980GG heifers. An association between theCXCR1genotype and necrosis of milk PMNL could not be demonstrated. Results indicate thatCXCR1polymorphisms influence viability and concentration of milk PMNL and provide a foundation for future research.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2014.05.008</identifier><language>eng</language><publisher>Oxford: Elsevier Limited</publisher><subject>Apoptosis ; Cytokines ; Deoxyribonucleic acid ; DNA ; DNA polymerase ; Genotype & phenotype ; Milk ; Veterinary medicine</subject><ispartof>Research in veterinary science, 2014-08, Vol.97 (1), p.55</ispartof><rights>Copyright Elsevier Limited Aug 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Verbeke, Joren</creatorcontrib><creatorcontrib>Piepers, Sofie</creatorcontrib><creatorcontrib>Peelman, Luc</creatorcontrib><creatorcontrib>van Poucke, Mario</creatorcontrib><creatorcontrib>De Vliegher, Sarne</creatorcontrib><title>Association ofCXCR1polymorphisms with apoptosis, necrosis and concentration of milk neutrophils in early lactating dairy heifers</title><title>Research in veterinary science</title><description>Associations between polymorphisms in the candidate geneCXCR1, encoding the chemokine (C-X-C motif) receptor 1, and udder health have been identified before. In the present study, associations between theCXCR1genotype (whole coding region) and apoptosis, necrosis, and concentration of milk polymorphonuclear neutrophilic leukocyte (PMNL) of 292 quarters belonging to 73 early lactating dairy heifers were studied. In uninfected quarters, % milk PMNL apoptosis was higher in c.980GG heifers [least squares means (LSM) 27%] compared to c.980AG heifers (LSM 16%), whereas in infected quarters, % milk PMNL apoptosis was higher in c.642GG heifers (LSM 29%) compared to c.642AG heifers (LSM 18%). Differences in milk PMNL concentration between infected and uninfected quarters were smaller in c.980AG heifers than in c.980GG heifers. An association between theCXCR1genotype and necrosis of milk PMNL could not be demonstrated. Results indicate thatCXCR1polymorphisms influence viability and concentration of milk PMNL and provide a foundation for future research.</description><subject>Apoptosis</subject><subject>Cytokines</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA polymerase</subject><subject>Genotype & phenotype</subject><subject>Milk</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNjz1PxDAQRC0EEuHgD1CtREty63yRK1EEuhpR0J0sn0McHG_wOqB0_HSCBD3VjDTvFSPEtcRMoqy3QxY-WGc5yjLDKkNsTkQiqyJP87qWpyJBLMq0ypvmXFwwD4hYSnmXiK97ZtJWRUseqGtf2ic5kVtGClNveWT4tLEHNdEUiS3fgjc6_DRQ_giavDY-hj8fRuveVmSOgVbfMVgPRgW3gFM6rph_haOyYYHe2M4EvhRnnXJsrn5zI24eH57bfToFep8Nx8NAc_DrdJBVudutn5qi-B_1DffrWbw</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Verbeke, Joren</creator><creator>Piepers, Sofie</creator><creator>Peelman, Luc</creator><creator>van Poucke, Mario</creator><creator>De Vliegher, Sarne</creator><general>Elsevier Limited</general><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20140801</creationdate><title>Association ofCXCR1polymorphisms with apoptosis, necrosis and concentration of milk neutrophils in early lactating dairy heifers</title><author>Verbeke, Joren ; Piepers, Sofie ; Peelman, Luc ; van Poucke, Mario ; De Vliegher, Sarne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_15499532833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Apoptosis</topic><topic>Cytokines</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA polymerase</topic><topic>Genotype & phenotype</topic><topic>Milk</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verbeke, Joren</creatorcontrib><creatorcontrib>Piepers, Sofie</creatorcontrib><creatorcontrib>Peelman, Luc</creatorcontrib><creatorcontrib>van Poucke, Mario</creatorcontrib><creatorcontrib>De Vliegher, Sarne</creatorcontrib><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verbeke, Joren</au><au>Piepers, Sofie</au><au>Peelman, Luc</au><au>van Poucke, Mario</au><au>De Vliegher, Sarne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association ofCXCR1polymorphisms with apoptosis, necrosis and concentration of milk neutrophils in early lactating dairy heifers</atitle><jtitle>Research in veterinary science</jtitle><date>2014-08-01</date><risdate>2014</risdate><volume>97</volume><issue>1</issue><spage>55</spage><pages>55-</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>Associations between polymorphisms in the candidate geneCXCR1, encoding the chemokine (C-X-C motif) receptor 1, and udder health have been identified before. In the present study, associations between theCXCR1genotype (whole coding region) and apoptosis, necrosis, and concentration of milk polymorphonuclear neutrophilic leukocyte (PMNL) of 292 quarters belonging to 73 early lactating dairy heifers were studied. In uninfected quarters, % milk PMNL apoptosis was higher in c.980GG heifers [least squares means (LSM) 27%] compared to c.980AG heifers (LSM 16%), whereas in infected quarters, % milk PMNL apoptosis was higher in c.642GG heifers (LSM 29%) compared to c.642AG heifers (LSM 18%). Differences in milk PMNL concentration between infected and uninfected quarters were smaller in c.980AG heifers than in c.980GG heifers. An association between theCXCR1genotype and necrosis of milk PMNL could not be demonstrated. 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| subjects | Apoptosis Cytokines Deoxyribonucleic acid DNA DNA polymerase Genotype & phenotype Milk Veterinary medicine |
| title | Association ofCXCR1polymorphisms with apoptosis, necrosis and concentration of milk neutrophils in early lactating dairy heifers |
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