CD4+CD25+Foxp3+Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in MouseCandida albicansTh17 Cell Infection Model
Th17 cells and CD4+CD25+Foxp3+regulatory T (Treg) cells are thought to promote and suppress inflammatory responses, respectively. Here we explore why under Th17 cell polarizing conditions, Treg cells did not suppress, but rather upregulated, the expression of interleukin-17A (IL-17A), IL-17F, and IL...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2011-03, Vol.34 (3), p.422 |
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| container_title | Immunity (Cambridge, Mass.) |
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| creator | Pandiyan, Pushpa Conti, Heather R Zheng, Lixin Peterson, Alanna C Mathern, Douglas R Hernández-Santos, Nydiaris Edgerton, Mira Gaffen, Sarah L Lenardo, Michael J |
| description | Th17 cells and CD4+CD25+Foxp3+regulatory T (Treg) cells are thought to promote and suppress inflammatory responses, respectively. Here we explore why under Th17 cell polarizing conditions, Treg cells did not suppress, but rather upregulated, the expression of interleukin-17A (IL-17A), IL-17F, and IL-22 from responding CD4+T cells (Tresp cells). Upregulation of IL-17 cytokines in Tresp cells was dependent on consumption of IL-2 by Treg cells, especially at early time points both in vitro and in vivo. During an oralCandida albicansinfection in mice, Treg cells induced IL-17 cytokines in Tresp cells, which markedly enhanced fungal clearance and recovery from infection. These findings show how Treg cells can promote acute Th17 cell responses to suppress mucosal fungus infections and reveal that Treg cells have a powerful capability to fight infections besides their role in maintaining tolerance or immune homeostasis. |
| doi_str_mv | 10.1016/j.immuni.2011.03.002 |
| format | Article |
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| ispartof | Immunity (Cambridge, Mass.), 2011-03, Vol.34 (3), p.422 |
| issn | 1074-7613 1097-4180 |
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| source | Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Competition Experiments Flow cytometry Fungal infections Immune system Inflammatory bowel disease Lymphocytes Proteins Software Viral infections |
| title | CD4+CD25+Foxp3+Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in MouseCandida albicansTh17 Cell Infection Model |
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