Establishment of pemetrexed-resistant non-small cell lung cancer cell lines

Highlights ► Pemetrexed-resistant non-small cell lung cancer cell lines have not been reported. ► They remained sensitive to docetaxel, vinorelbine, 5-fluorouracil, and irinotecan. ► Thymidylate synthase expression was increased in the resistant cells. ► The cells could be basic tools for identifyin...

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Veröffentlicht in:	Cancer letters 2011-10, Vol.309 (2), p.228-235
Hauptverfasser:	Zhang, Dan, Ochi, Nobuaki, Takigawa, Nagio, Tanimoto, Yasushi, Chen, Yanyan, Ichihara, Eiki, Hotta, Katsuyuki, Tabata, Masahiro, Tanimoto, Mitsune, Kiura, Katsuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma of Lung Antineoplastic Agents - pharmacology Camptothecin - analogs & derivatives Camptothecin - pharmacology Cancer therapies Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Cell Proliferation Chemotherapy cisplatin Cisplatin - pharmacology cross resistance Dihydrofolate reductase Docetaxel Drug Resistance, Neoplasm - genetics Drug therapy Fluorouracil - pharmacology Folic Acid Antagonists - pharmacology Gene Expression genes Glutamates - pharmacology growth retardation Guanine - analogs & derivatives Guanine - pharmacology Hematology, Oncology and Palliative Medicine Humans Immunoblotting Irinotecan Lung cancer lung neoplasms Lung Neoplasms - genetics Lung Neoplasms - metabolism metabolites Non-small cell lung cancer patients Pemetrexed Phosphoribosylglycinamide Formyltransferase - genetics Resistance Reverse Transcriptase Polymerase Chain Reaction Taxoids - pharmacology Tetrahydrofolate Dehydrogenase - biosynthesis Tetrahydrofolate Dehydrogenase - genetics Thymidylate synthase Thymidylate Synthase - biosynthesis Thymidylate Synthase - genetics toxicity Vinblastine - analogs & derivatives Vinblastine - pharmacology Vinorelbine Western blotting
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Zusammenfassung:	Highlights ► Pemetrexed-resistant non-small cell lung cancer cell lines have not been reported. ► They remained sensitive to docetaxel, vinorelbine, 5-fluorouracil, and irinotecan. ► Thymidylate synthase expression was increased in the resistant cells. ► The cells could be basic tools for identifying new drugs to overcome the resistance.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2011.06.006