Alternative codon usage of PRRS virus ORF5 gene increases eucaryotic expression of GP5glycoprotein and improves immune response in challenged pigs

Pigs exposed to GP5protein of PRRSV by means of DNA immunization develop specific neutralizing and protecting antibodies. Herein, we report on the consequences of codon bias, and on the favorable outcome of the systematic replacement of native codons of PRRSV ORF5 gene with codons chosen to reflect...

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Veröffentlicht in:	Vaccine 2005-07, Vol.23 (31), p.4016
Hauptverfasser:	Kheyar, Ali, Jabrane, Ahmed, Zhu, Chengru, Cléroux, Patrick, Massie, Bernard, Dea, Serge, Gagnon, Carl A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Cytokines Deoxyribonucleic acid DNA E coli Experiments Genes Genomes Immune response Immunization Mammals Plasmids Proteins Swine Vaccines
Online-Zugang:	Volltext
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