Balance between somatostatin and D2 receptor expression drives TSH-secreting adenoma response to somatostatin analogues and dopastatins

Summary Context First‐line therapy for thyrotropin‐secreting pituitary adenomas (TSHomas) is neurosurgery, while medical treatment rests mainly on somatostatin analogues. Clinically available sst2‐preferring analogues, octreotide and lanreotide, induce normalization of hormone levels in approximate...

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Veröffentlicht in:	Clinical endocrinology (Oxford) 2012-03, Vol.76 (3), p.407-414
Hauptverfasser:	Gatto, Federico, Barbieri, Federica, Gatti, Monica, Wurth, Roberto, Schulz, Stefan, Ravetti, Jean-Louis, Zona, Gianluigi, Culler, Michael D., Saveanu, Alexandru, Giusti, Massimo, Minuto, Francesco, Hofland, Leo J., Ferone, Diego, Florio, Tullio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - drug therapy Adenoma - genetics Adenoma - metabolism Adult Biological and medical sciences Cabergoline Cell Proliferation - drug effects Dopamine Dopamine - analogs & derivatives Dopamine - pharmacology Dopamine - therapeutic use Dopamine Agonists - pharmacology Dopamine Agonists - therapeutic use Drug Synergism Endocrinopathies Ergolines - pharmacology Ergolines - therapeutic use Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Humans Immunohistochemistry Male Medical sciences Octreotide - pharmacology Octreotide - therapeutic use Patients Pituitary gland Pituitary Neoplasms - drug therapy Pituitary Neoplasms - genetics Pituitary Neoplasms - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Receptors, Somatostatin - genetics Receptors, Somatostatin - metabolism Reverse Transcriptase Polymerase Chain Reaction Somatostatin - analogs & derivatives Somatostatin - pharmacology Somatostatin - therapeutic use Thyrotropin - blood Thyrotropin - metabolism Thyroxine - blood Treatment Outcome Triiodothyronine - blood Tumor Cells, Cultured Vertebrates: endocrinology
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