Shikonin reduces oedema induced by phorbol ester by interfering with I[kappa]B[alpha] degradation thus inhibiting translocation of NF-[kappa]B to the nucleus

Background and purpose: In the present paper we studied the effect of shikonin on ear oedema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), and determined the mechanisms through which shikonin might exert its topical anti-inflammatory action. Experimental approach: Acute ear oedema was induc...

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Veröffentlicht in:	British journal of pharmacology 2010-05, Vol.160 (2), p.376
Hauptverfasser:	Andujar, I, Recio, MC, Bacelli, T, Giner, RM, Rios, JL
Format:	Artikel
Sprache:	eng
Schlagworte:	Deoxyribonucleic acid DNA Kinases Nitric oxide Proteins
Online-Zugang:	Volltext
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