Protective effect of Zingiber officinale extract on rat testis after cyclophosphamide treatment
Summary Decreasing the side effects of chemotherapy in testis has been the subjects of many studies. In this study, the protective effects of Zingiber officinale extract on rat testis were investigated after chemotherapy with cyclophosphamide. Histological and biochemical parameters were compared in...
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| Veröffentlicht in: | Andrologia 2014-08, Vol.46 (6), p.680-686 |
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| creator | Mohammadi, F. Nikzad, H. Taghizadeh, M. Taherian, A. Azami-Tameh, A. Hosseini, S. M. Moravveji, A. |
| description | Summary
Decreasing the side effects of chemotherapy in testis has been the subjects of many studies. In this study, the protective effects of Zingiber officinale extract on rat testis were investigated after chemotherapy with cyclophosphamide. Histological and biochemical parameters were compared in cyclophosphamide‐treated rats with or without ginger extract intake. Wistar male rats were randomly divided into four groups each 10. The control group received a single injection of 1 ml isotonic saline intraperitoneally. The Cyclophosphamide (CP) group received a single dose of cyclophosphamide (100 mg kg−1 BW) intraperitoneally. CP + 300 and CP + 600 groups received orally 300 or 600 mg of ginger extract, respectively, for a period of 6 weeks after cyclophosphamide injection. The morphologic and histological structure of the testis was compared in different groups of the rats. Also, factors like malondialdehyde, reactive oxygen species, total antioxidant capacity and testosterone level were assessed in blood serum as well. Our results showed that although ginger extract could not change testis weight, malondialdehyde (MDA) and ROS, but antioxidant and testosterone levels in serum were increased significantly. Also, an obvious improved histological change was seen in CP + 300 and CP + 600 groups in comparison with CP group. These protective effects of ginger on rat testis after cyclophosphamide treatment could be attributed to the higher serum level of antioxidants. |
| doi_str_mv | 10.1111/and.12135 |
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Decreasing the side effects of chemotherapy in testis has been the subjects of many studies. In this study, the protective effects of Zingiber officinale extract on rat testis were investigated after chemotherapy with cyclophosphamide. Histological and biochemical parameters were compared in cyclophosphamide‐treated rats with or without ginger extract intake. Wistar male rats were randomly divided into four groups each 10. The control group received a single injection of 1 ml isotonic saline intraperitoneally. The Cyclophosphamide (CP) group received a single dose of cyclophosphamide (100 mg kg−1 BW) intraperitoneally. CP + 300 and CP + 600 groups received orally 300 or 600 mg of ginger extract, respectively, for a period of 6 weeks after cyclophosphamide injection. The morphologic and histological structure of the testis was compared in different groups of the rats. Also, factors like malondialdehyde, reactive oxygen species, total antioxidant capacity and testosterone level were assessed in blood serum as well. Our results showed that although ginger extract could not change testis weight, malondialdehyde (MDA) and ROS, but antioxidant and testosterone levels in serum were increased significantly. Also, an obvious improved histological change was seen in CP + 300 and CP + 600 groups in comparison with CP group. These protective effects of ginger on rat testis after cyclophosphamide treatment could be attributed to the higher serum level of antioxidants.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.12135</identifier><identifier>PMID: 23889539</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Animals ; Antineoplastic Agents, Alkylating - toxicity ; Antioxidants - metabolism ; Cyclophosphamide ; Cyclophosphamide - toxicity ; Male ; Malondialdehyde - metabolism ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; Reactive Oxygen Species - metabolism ; Sertoli Cells - drug effects ; Sertoli Cells - pathology ; Sperm Count ; testis ; Testis - drug effects ; Testis - metabolism ; Testis - pathology ; Testosterone - blood ; Zingiber officinale</subject><ispartof>Andrologia, 2014-08, Vol.46 (6), p.680-686</ispartof><rights>2013 Blackwell Verlag GmbH</rights><rights>2013 Blackwell Verlag GmbH.</rights><rights>Copyright © 2014 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3915-d9a567b11badb8a2e4afccf1a6e243635d07a452a7f81f904360a3dfcbc3976c3</citedby><cites>FETCH-LOGICAL-c3915-d9a567b11badb8a2e4afccf1a6e243635d07a452a7f81f904360a3dfcbc3976c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.12135$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.12135$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23889539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohammadi, F.</creatorcontrib><creatorcontrib>Nikzad, H.</creatorcontrib><creatorcontrib>Taghizadeh, M.</creatorcontrib><creatorcontrib>Taherian, A.</creatorcontrib><creatorcontrib>Azami-Tameh, A.</creatorcontrib><creatorcontrib>Hosseini, S. M.</creatorcontrib><creatorcontrib>Moravveji, A.</creatorcontrib><title>Protective effect of Zingiber officinale extract on rat testis after cyclophosphamide treatment</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Summary
Decreasing the side effects of chemotherapy in testis has been the subjects of many studies. In this study, the protective effects of Zingiber officinale extract on rat testis were investigated after chemotherapy with cyclophosphamide. Histological and biochemical parameters were compared in cyclophosphamide‐treated rats with or without ginger extract intake. Wistar male rats were randomly divided into four groups each 10. The control group received a single injection of 1 ml isotonic saline intraperitoneally. The Cyclophosphamide (CP) group received a single dose of cyclophosphamide (100 mg kg−1 BW) intraperitoneally. CP + 300 and CP + 600 groups received orally 300 or 600 mg of ginger extract, respectively, for a period of 6 weeks after cyclophosphamide injection. The morphologic and histological structure of the testis was compared in different groups of the rats. Also, factors like malondialdehyde, reactive oxygen species, total antioxidant capacity and testosterone level were assessed in blood serum as well. Our results showed that although ginger extract could not change testis weight, malondialdehyde (MDA) and ROS, but antioxidant and testosterone levels in serum were increased significantly. Also, an obvious improved histological change was seen in CP + 300 and CP + 600 groups in comparison with CP group. These protective effects of ginger on rat testis after cyclophosphamide treatment could be attributed to the higher serum level of antioxidants.</description><subject>Animals</subject><subject>Antineoplastic Agents, Alkylating - toxicity</subject><subject>Antioxidants - metabolism</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - toxicity</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Sertoli Cells - drug effects</subject><subject>Sertoli Cells - pathology</subject><subject>Sperm Count</subject><subject>testis</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><subject>Testis - pathology</subject><subject>Testosterone - blood</subject><subject>Zingiber officinale</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PAyEQhonRaFN78A-YTTx52BYWWHaPpn4mTfWgMfFCZlmw1P2oQNX-e9GqN-fChHnedyYvQkcEj0msCXT1mGSE8h00IIyWKc5EtosGmGKaMp6XB2jk_RLHYlwIxvbRQUaLouS0HCB55_qgVbBvOtHGxC7pTfJku2dbaRd7Y5XtoInTj-Dga9wlDkIStA_WJ2BCxNRGNf1q0fvVAlpb6yQ4DaHVXThEewYar0c_7xA9XF7cT6_T2e3VzfRslipaEp7WJfBcVIRUUFcFZJqBUcoQyHXGaE55jQUwnoEwBTEljn8YaG1UFfUiV3SITra-K9e_ruNtctmvXTzcS8IZxxnluIjU6ZZSrvfeaSNXzrbgNpJg-ZWmjGnK7zQje_zjuK5aXf-Rv9lFYLIF3m2jN_87ybP5-a9lulVYH_THnwLci8wFFVw-zq_kOS3KKSYsLvoECc2N6w</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Mohammadi, F.</creator><creator>Nikzad, H.</creator><creator>Taghizadeh, M.</creator><creator>Taherian, A.</creator><creator>Azami-Tameh, A.</creator><creator>Hosseini, S. M.</creator><creator>Moravveji, A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope></search><sort><creationdate>201408</creationdate><title>Protective effect of Zingiber officinale extract on rat testis after cyclophosphamide treatment</title><author>Mohammadi, F. ; Nikzad, H. ; Taghizadeh, M. ; Taherian, A. ; Azami-Tameh, A. ; Hosseini, S. M. ; Moravveji, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3915-d9a567b11badb8a2e4afccf1a6e243635d07a452a7f81f904360a3dfcbc3976c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Alkylating - toxicity</topic><topic>Antioxidants - metabolism</topic><topic>Cyclophosphamide</topic><topic>Cyclophosphamide - toxicity</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Sertoli Cells - drug effects</topic><topic>Sertoli Cells - pathology</topic><topic>Sperm Count</topic><topic>testis</topic><topic>Testis - drug effects</topic><topic>Testis - metabolism</topic><topic>Testis - pathology</topic><topic>Testosterone - blood</topic><topic>Zingiber officinale</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohammadi, F.</creatorcontrib><creatorcontrib>Nikzad, H.</creatorcontrib><creatorcontrib>Taghizadeh, M.</creatorcontrib><creatorcontrib>Taherian, A.</creatorcontrib><creatorcontrib>Azami-Tameh, A.</creatorcontrib><creatorcontrib>Hosseini, S. M.</creatorcontrib><creatorcontrib>Moravveji, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohammadi, F.</au><au>Nikzad, H.</au><au>Taghizadeh, M.</au><au>Taherian, A.</au><au>Azami-Tameh, A.</au><au>Hosseini, S. M.</au><au>Moravveji, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of Zingiber officinale extract on rat testis after cyclophosphamide treatment</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2014-08</date><risdate>2014</risdate><volume>46</volume><issue>6</issue><spage>680</spage><epage>686</epage><pages>680-686</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>Summary
Decreasing the side effects of chemotherapy in testis has been the subjects of many studies. In this study, the protective effects of Zingiber officinale extract on rat testis were investigated after chemotherapy with cyclophosphamide. Histological and biochemical parameters were compared in cyclophosphamide‐treated rats with or without ginger extract intake. Wistar male rats were randomly divided into four groups each 10. The control group received a single injection of 1 ml isotonic saline intraperitoneally. The Cyclophosphamide (CP) group received a single dose of cyclophosphamide (100 mg kg−1 BW) intraperitoneally. CP + 300 and CP + 600 groups received orally 300 or 600 mg of ginger extract, respectively, for a period of 6 weeks after cyclophosphamide injection. The morphologic and histological structure of the testis was compared in different groups of the rats. Also, factors like malondialdehyde, reactive oxygen species, total antioxidant capacity and testosterone level were assessed in blood serum as well. Our results showed that although ginger extract could not change testis weight, malondialdehyde (MDA) and ROS, but antioxidant and testosterone levels in serum were increased significantly. Also, an obvious improved histological change was seen in CP + 300 and CP + 600 groups in comparison with CP group. These protective effects of ginger on rat testis after cyclophosphamide treatment could be attributed to the higher serum level of antioxidants.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>23889539</pmid><doi>10.1111/and.12135</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antineoplastic Agents, Alkylating - toxicity Antioxidants - metabolism Cyclophosphamide Cyclophosphamide - toxicity Male Malondialdehyde - metabolism Plant Extracts - pharmacology Rats Rats, Wistar Reactive Oxygen Species - metabolism Sertoli Cells - drug effects Sertoli Cells - pathology Sperm Count testis Testis - drug effects Testis - metabolism Testis - pathology Testosterone - blood Zingiber officinale |
| title | Protective effect of Zingiber officinale extract on rat testis after cyclophosphamide treatment |
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