Lymph node metastasis and p53 overexpression in combination for the prognosis for the colorectal cancer
Background. Lymph node metastasis has been recognized as the most reliable prognostic factor for colorectal cancer. Of late, the clinical significance of p53 as a prognostic factor has been reported. The purpose of the current study was to elucidate the significance of these two factors in combinati...
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| Veröffentlicht in: | International journal of clinical oncology 1999-11, Vol.4 (5), p.280-284 |
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| creator | Yamamura, T. Matsuzaki, H. Suda, T. Ozasa, T. Matsuoka, H. Ikai, H. Oikawa, H. Akaish, O. Tsukikawa, S. Yamaguchi, S. |
| description | Background. Lymph node metastasis has been recognized as the most reliable prognostic factor for colorectal cancer. Of late, the clinical significance of p53 as a prognostic factor has been reported. The purpose of the current study was to elucidate the significance of these two factors in combination as a prognostic indicator for colorectal cancer. Methods. One hundred forty-four patients with colorectal cancer were examined. The expression of p53 was determined by immunohistochemical staining. Patient data, lymph node metastasis, p53 expression, recurrence rate, 5-year survival, and disease-free survival were studied. Results. The recurrence rate for patients with p53- and n1 in combination was 21%, and that for patients with p53+ and n1 in combination was 63%, a significant difference. The 5-year survival rate for patients with p53- and n1 in combination was not significantly different from that for patients with p53+ and n1 in combination (78.7% vs. 57.5%); however, the 5-year disease-free survival rate for patients with p53- and n1 in combination was significantly better than that for patients with p53+ and n1 in combination (78.6% vs. 38.2%). Conclusion. The combination criterion of lymph node metastasis and p53 expression should be a useful prognosticator for colorectal cancer.[PUBLICATION ABSTRACT] |
| doi_str_mv | 10.1007/s101470050068 |
| format | Article |
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Lymph node metastasis has been recognized as the most reliable prognostic factor for colorectal cancer. Of late, the clinical significance of p53 as a prognostic factor has been reported. The purpose of the current study was to elucidate the significance of these two factors in combination as a prognostic indicator for colorectal cancer. Methods. One hundred forty-four patients with colorectal cancer were examined. The expression of p53 was determined by immunohistochemical staining. Patient data, lymph node metastasis, p53 expression, recurrence rate, 5-year survival, and disease-free survival were studied. Results. The recurrence rate for patients with p53- and n1 in combination was 21%, and that for patients with p53+ and n1 in combination was 63%, a significant difference. The 5-year survival rate for patients with p53- and n1 in combination was not significantly different from that for patients with p53+ and n1 in combination (78.7% vs. 57.5%); however, the 5-year disease-free survival rate for patients with p53- and n1 in combination was significantly better than that for patients with p53+ and n1 in combination (78.6% vs. 38.2%). Conclusion. The combination criterion of lymph node metastasis and p53 expression should be a useful prognosticator for colorectal cancer.[PUBLICATION ABSTRACT]</description><identifier>ISSN: 1341-9625</identifier><identifier>EISSN: 1437-7772</identifier><identifier>DOI: 10.1007/s101470050068</identifier><language>eng</language><publisher>Tokyo: Springer Nature B.V</publisher><subject>Colorectal cancer ; Medical prognosis ; Metastasis</subject><ispartof>International journal of clinical oncology, 1999-11, Vol.4 (5), p.280-284</ispartof><rights>The Japan Society of Clinical Oncology 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Yamamura, T.</creatorcontrib><creatorcontrib>Matsuzaki, H.</creatorcontrib><creatorcontrib>Suda, T.</creatorcontrib><creatorcontrib>Ozasa, T.</creatorcontrib><creatorcontrib>Matsuoka, H.</creatorcontrib><creatorcontrib>Ikai, H.</creatorcontrib><creatorcontrib>Oikawa, H.</creatorcontrib><creatorcontrib>Akaish, O.</creatorcontrib><creatorcontrib>Tsukikawa, S.</creatorcontrib><creatorcontrib>Yamaguchi, S.</creatorcontrib><title>Lymph node metastasis and p53 overexpression in combination for the prognosis for the colorectal cancer</title><title>International journal of clinical oncology</title><description>Background. Lymph node metastasis has been recognized as the most reliable prognostic factor for colorectal cancer. Of late, the clinical significance of p53 as a prognostic factor has been reported. The purpose of the current study was to elucidate the significance of these two factors in combination as a prognostic indicator for colorectal cancer. Methods. One hundred forty-four patients with colorectal cancer were examined. The expression of p53 was determined by immunohistochemical staining. Patient data, lymph node metastasis, p53 expression, recurrence rate, 5-year survival, and disease-free survival were studied. Results. The recurrence rate for patients with p53- and n1 in combination was 21%, and that for patients with p53+ and n1 in combination was 63%, a significant difference. The 5-year survival rate for patients with p53- and n1 in combination was not significantly different from that for patients with p53+ and n1 in combination (78.7% vs. 57.5%); however, the 5-year disease-free survival rate for patients with p53- and n1 in combination was significantly better than that for patients with p53+ and n1 in combination (78.6% vs. 38.2%). Conclusion. The combination criterion of lymph node metastasis and p53 expression should be a useful prognosticator for colorectal cancer.[PUBLICATION ABSTRACT]</description><subject>Colorectal cancer</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><issn>1341-9625</issn><issn>1437-7772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpVUE1Lw0AQXUTBWj16X_Acnf3KJEcpaoWCFz2HzWbSpjS7cTcV--9NqR6EgZn3eDPzeIzdCrgXAPiQBAiNAAYgL87YTGiFGSLK82lWWmRlLs0lu0ppCyAwN3LG1qtDP2y4Dw3xnkabpuoSt77hg1E8fFGk7yFSSl3wvPPchb7uvB2PsA2RjxviQwxrH457f4wLuxDJjXbHnfWO4jW7aO0u0c1vn7OP56f3xTJbvb28Lh5XmRO5GrPcCoGyzJG0zCfPqnBKokZRC21MUahCWipbaGppaihlY6AAZ53F1mpCUnN2d7o7efrcUxqrbdhHP72shNG6MKg0TqrspHIxpBSprYbY9TYeKgHVMcvqX5bqB7-bZmk</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Yamamura, T.</creator><creator>Matsuzaki, H.</creator><creator>Suda, T.</creator><creator>Ozasa, T.</creator><creator>Matsuoka, H.</creator><creator>Ikai, H.</creator><creator>Oikawa, H.</creator><creator>Akaish, O.</creator><creator>Tsukikawa, S.</creator><creator>Yamaguchi, S.</creator><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>19991101</creationdate><title>Lymph node metastasis and p53 overexpression in combination for the prognosis for the colorectal cancer</title><author>Yamamura, T. ; Matsuzaki, H. ; Suda, T. ; Ozasa, T. ; Matsuoka, H. ; Ikai, H. ; Oikawa, H. ; Akaish, O. ; Tsukikawa, S. ; Yamaguchi, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c163t-6a1172967e42613438c327471b145588382ae9f0db25b092d5080caca7fa4e7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Colorectal cancer</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamura, T.</creatorcontrib><creatorcontrib>Matsuzaki, H.</creatorcontrib><creatorcontrib>Suda, T.</creatorcontrib><creatorcontrib>Ozasa, T.</creatorcontrib><creatorcontrib>Matsuoka, H.</creatorcontrib><creatorcontrib>Ikai, H.</creatorcontrib><creatorcontrib>Oikawa, H.</creatorcontrib><creatorcontrib>Akaish, O.</creatorcontrib><creatorcontrib>Tsukikawa, S.</creatorcontrib><creatorcontrib>Yamaguchi, S.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>International journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamura, T.</au><au>Matsuzaki, H.</au><au>Suda, T.</au><au>Ozasa, T.</au><au>Matsuoka, H.</au><au>Ikai, H.</au><au>Oikawa, H.</au><au>Akaish, O.</au><au>Tsukikawa, S.</au><au>Yamaguchi, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymph node metastasis and p53 overexpression in combination for the prognosis for the colorectal cancer</atitle><jtitle>International journal of clinical oncology</jtitle><date>1999-11-01</date><risdate>1999</risdate><volume>4</volume><issue>5</issue><spage>280</spage><epage>284</epage><pages>280-284</pages><issn>1341-9625</issn><eissn>1437-7772</eissn><abstract>Background. Lymph node metastasis has been recognized as the most reliable prognostic factor for colorectal cancer. Of late, the clinical significance of p53 as a prognostic factor has been reported. The purpose of the current study was to elucidate the significance of these two factors in combination as a prognostic indicator for colorectal cancer. Methods. One hundred forty-four patients with colorectal cancer were examined. The expression of p53 was determined by immunohistochemical staining. Patient data, lymph node metastasis, p53 expression, recurrence rate, 5-year survival, and disease-free survival were studied. Results. The recurrence rate for patients with p53- and n1 in combination was 21%, and that for patients with p53+ and n1 in combination was 63%, a significant difference. The 5-year survival rate for patients with p53- and n1 in combination was not significantly different from that for patients with p53+ and n1 in combination (78.7% vs. 57.5%); however, the 5-year disease-free survival rate for patients with p53- and n1 in combination was significantly better than that for patients with p53+ and n1 in combination (78.6% vs. 38.2%). Conclusion. The combination criterion of lymph node metastasis and p53 expression should be a useful prognosticator for colorectal cancer.[PUBLICATION ABSTRACT]</abstract><cop>Tokyo</cop><pub>Springer Nature B.V</pub><doi>10.1007/s101470050068</doi><tpages>5</tpages></addata></record> |
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| subjects | Colorectal cancer Medical prognosis Metastasis |
| title | Lymph node metastasis and p53 overexpression in combination for the prognosis for the colorectal cancer |
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