Ethanol Feeding Potentiates the Pro-Inflammatory Response of Kupffer Cells to Cellular Fibronectin

Background: Excessive alcohol consumption leads to the increased extracellular matrix deposition of cellular fibronectin (cFn) in the liver, which is also implicated as an initiating event in the fibrogenic process. We propose that cFn directly stimulates Kupffer cells (KCs), which are involved in...

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Veröffentlicht in:	Alcoholism, clinical and experimental research clinical and experimental research, 2011-04, Vol.35 (4), p.717-725
Hauptverfasser:	Aziz-Seible, Razia S., Lee, Serene M., Kharbanda, Kusum K., McVicker, Benita L., Casey, Carol A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Caspase 3 - metabolism Cell Culture Techniques Cell Survival - drug effects Cellular Fibronectin Central Nervous System Depressants - metabolism Central Nervous System Depressants - pharmacology Central Nervous System Depressants - toxicity Ethanol Ethanol - metabolism Ethanol - pharmacology Ethanol - toxicity Extracellular Matrix - physiology Fibronectins - physiology Inflammation - chemically induced Inflammation - physiopathology Interleukin-6 - metabolism Kupffer Cells Kupffer Cells - cytology Kupffer Cells - drug effects Kupffer Cells - pathology Kupffer Cells - physiology Liver - cytology Liver - physiopathology Male Matrix Metalloproteinase 2 Medical sciences Rats Rats, Wistar Tissue Inhibitor of Metalloproteinase-2 - metabolism Toxicology Tumor Necrosis Factor-alpha
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