Low-dose ethanol aggravates allergic dermatitis in mice
Abstract Alcohol injures dendritic cells and suppresses cellular immunity, while some evidence indicates that drinking alcohol aggravates allergic asthma. This study investigated the effect of low doses of ethanol in enhancing allergic reactions in the skin of mice. Liquid food containing alcohol wa...
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Veröffentlicht in: | Alcohol (Fayetteville, N.Y.) N.Y.), 2014-08, Vol.48 (5), p.501-508 |
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description | Abstract Alcohol injures dendritic cells and suppresses cellular immunity, while some evidence indicates that drinking alcohol aggravates allergic asthma. This study investigated the effect of low doses of ethanol in enhancing allergic reactions in the skin of mice. Liquid food containing alcohol was administered to conventional NC/Nga mice to induce alcoholic hepatic steatosis, and spontaneous dermatitis was evaluated. BALB/c mice were administered approximately 1 g/kg body weight of ethanol by gavage, and contact hypersensitivity (CHS) or active cutaneous anaphylaxis (ACA) was induced. Spleens were collected 24 h after the elicitation of CHS and mRNA expressions of interferon (IFN)-γ, interleukin (IL)-4, IL-6, IL-10, and IL-18 were measured by quantitative RT-PCR. Alcohol-containing diet exaggerated spontaneous dermatitis in conventional NC/Nga mice and contact hypersensitivity in BALB/c mice. Ethanol administered by gavage for 5 days enhanced contact hypersensitivity in BALB/c mice. Ethanol administration with gavage also enhanced ACA of BALB/c mice. Ethanol did not affect mRNA expression of IFN-γ and IL-4, but did enhance IL-6, IL-10, and IL-18 mRNA expression. Histological evaluation revealed an absence of hepatic steatosis in mice administered ethanol by gavage for 5 days. In ethanol-administered mice, inflamed areas presented as lesions or a local extreme accumulation of mononuclear cells in the epidermis. These findings suggest that ethanol enhances the expression of inflammatory cytokines independently from T helper (Th)1/Th2 cytokine phenotypes, causing abnormalities in the epidermis resulting in exacerbated allergic reactivity. |
doi_str_mv | 10.1016/j.alcohol.2014.05.001 |
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This study investigated the effect of low doses of ethanol in enhancing allergic reactions in the skin of mice. Liquid food containing alcohol was administered to conventional NC/Nga mice to induce alcoholic hepatic steatosis, and spontaneous dermatitis was evaluated. BALB/c mice were administered approximately 1 g/kg body weight of ethanol by gavage, and contact hypersensitivity (CHS) or active cutaneous anaphylaxis (ACA) was induced. Spleens were collected 24 h after the elicitation of CHS and mRNA expressions of interferon (IFN)-γ, interleukin (IL)-4, IL-6, IL-10, and IL-18 were measured by quantitative RT-PCR. Alcohol-containing diet exaggerated spontaneous dermatitis in conventional NC/Nga mice and contact hypersensitivity in BALB/c mice. Ethanol administered by gavage for 5 days enhanced contact hypersensitivity in BALB/c mice. Ethanol administration with gavage also enhanced ACA of BALB/c mice. Ethanol did not affect mRNA expression of IFN-γ and IL-4, but did enhance IL-6, IL-10, and IL-18 mRNA expression. Histological evaluation revealed an absence of hepatic steatosis in mice administered ethanol by gavage for 5 days. In ethanol-administered mice, inflamed areas presented as lesions or a local extreme accumulation of mononuclear cells in the epidermis. These findings suggest that ethanol enhances the expression of inflammatory cytokines independently from T helper (Th)1/Th2 cytokine phenotypes, causing abnormalities in the epidermis resulting in exacerbated allergic reactivity.</description><identifier>ISSN: 0741-8329</identifier><identifier>EISSN: 1873-6823</identifier><identifier>DOI: 10.1016/j.alcohol.2014.05.001</identifier><identifier>PMID: 24953256</identifier><identifier>CODEN: ALCOEX</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alcohol ; Allergies ; Allergy ; Anaphylaxis - immunology ; Animals ; Aqueous solutions ; Asthma ; Dermatitis ; Dermatitis, Atopic - chemically induced ; Dermatitis, Contact - etiology ; Diet ; Ethanol ; Ethanol - toxicity ; Experiments ; Female ; Hair ; Hypotheses ; Interferon-gamma ; Interleukin-10 ; Interleukin-4 ; Interleukin-6 ; Lymphocytes ; Mice, Inbred BALB C ; Olive oil ; Passive Cutaneous Anaphylaxis - immunology ; Permeability ; Psychiatry ; Skin ; Studies</subject><ispartof>Alcohol (Fayetteville, N.Y.), 2014-08, Vol.48 (5), p.501-508</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-19572fbad5a054898d178002aa12e68c065e1aa7bd946df56051e9b3452a3ca53</citedby><cites>FETCH-LOGICAL-c518t-19572fbad5a054898d178002aa12e68c065e1aa7bd946df56051e9b3452a3ca53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1544192384?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993,64383,64387,72239</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24953256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakazaki, Fumitoshi</creatorcontrib><creatorcontrib>Ogino, Hirofumi</creatorcontrib><creatorcontrib>Arakawa, Tomohiro</creatorcontrib><creatorcontrib>Okuno, Tomofumi</creatorcontrib><creatorcontrib>Ueno, Hitoshi</creatorcontrib><title>Low-dose ethanol aggravates allergic dermatitis in mice</title><title>Alcohol (Fayetteville, N.Y.)</title><addtitle>Alcohol</addtitle><description>Abstract Alcohol injures dendritic cells and suppresses cellular immunity, while some evidence indicates that drinking alcohol aggravates allergic asthma. This study investigated the effect of low doses of ethanol in enhancing allergic reactions in the skin of mice. Liquid food containing alcohol was administered to conventional NC/Nga mice to induce alcoholic hepatic steatosis, and spontaneous dermatitis was evaluated. BALB/c mice were administered approximately 1 g/kg body weight of ethanol by gavage, and contact hypersensitivity (CHS) or active cutaneous anaphylaxis (ACA) was induced. Spleens were collected 24 h after the elicitation of CHS and mRNA expressions of interferon (IFN)-γ, interleukin (IL)-4, IL-6, IL-10, and IL-18 were measured by quantitative RT-PCR. Alcohol-containing diet exaggerated spontaneous dermatitis in conventional NC/Nga mice and contact hypersensitivity in BALB/c mice. Ethanol administered by gavage for 5 days enhanced contact hypersensitivity in BALB/c mice. Ethanol administration with gavage also enhanced ACA of BALB/c mice. Ethanol did not affect mRNA expression of IFN-γ and IL-4, but did enhance IL-6, IL-10, and IL-18 mRNA expression. Histological evaluation revealed an absence of hepatic steatosis in mice administered ethanol by gavage for 5 days. In ethanol-administered mice, inflamed areas presented as lesions or a local extreme accumulation of mononuclear cells in the epidermis. These findings suggest that ethanol enhances the expression of inflammatory cytokines independently from T helper (Th)1/Th2 cytokine phenotypes, causing abnormalities in the epidermis resulting in exacerbated allergic reactivity.</description><subject>Alcohol</subject><subject>Allergies</subject><subject>Allergy</subject><subject>Anaphylaxis - immunology</subject><subject>Animals</subject><subject>Aqueous solutions</subject><subject>Asthma</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - chemically induced</subject><subject>Dermatitis, Contact - etiology</subject><subject>Diet</subject><subject>Ethanol</subject><subject>Ethanol - toxicity</subject><subject>Experiments</subject><subject>Female</subject><subject>Hair</subject><subject>Hypotheses</subject><subject>Interferon-gamma</subject><subject>Interleukin-10</subject><subject>Interleukin-4</subject><subject>Interleukin-6</subject><subject>Lymphocytes</subject><subject>Mice, Inbred BALB C</subject><subject>Olive 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toxicity</topic><topic>Experiments</topic><topic>Female</topic><topic>Hair</topic><topic>Hypotheses</topic><topic>Interferon-gamma</topic><topic>Interleukin-10</topic><topic>Interleukin-4</topic><topic>Interleukin-6</topic><topic>Lymphocytes</topic><topic>Mice, Inbred BALB C</topic><topic>Olive oil</topic><topic>Passive Cutaneous Anaphylaxis - immunology</topic><topic>Permeability</topic><topic>Psychiatry</topic><topic>Skin</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakazaki, Fumitoshi</creatorcontrib><creatorcontrib>Ogino, Hirofumi</creatorcontrib><creatorcontrib>Arakawa, Tomohiro</creatorcontrib><creatorcontrib>Okuno, Tomofumi</creatorcontrib><creatorcontrib>Ueno, Hitoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakazaki, Fumitoshi</au><au>Ogino, Hirofumi</au><au>Arakawa, Tomohiro</au><au>Okuno, Tomofumi</au><au>Ueno, Hitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-dose ethanol aggravates allergic dermatitis in mice</atitle><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle><addtitle>Alcohol</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>48</volume><issue>5</issue><spage>501</spage><epage>508</epage><pages>501-508</pages><issn>0741-8329</issn><eissn>1873-6823</eissn><coden>ALCOEX</coden><abstract>Abstract Alcohol injures dendritic cells and suppresses cellular immunity, while some evidence indicates that drinking alcohol aggravates allergic asthma. This study investigated the effect of low doses of ethanol in enhancing allergic reactions in the skin of mice. Liquid food containing alcohol was administered to conventional NC/Nga mice to induce alcoholic hepatic steatosis, and spontaneous dermatitis was evaluated. BALB/c mice were administered approximately 1 g/kg body weight of ethanol by gavage, and contact hypersensitivity (CHS) or active cutaneous anaphylaxis (ACA) was induced. Spleens were collected 24 h after the elicitation of CHS and mRNA expressions of interferon (IFN)-γ, interleukin (IL)-4, IL-6, IL-10, and IL-18 were measured by quantitative RT-PCR. Alcohol-containing diet exaggerated spontaneous dermatitis in conventional NC/Nga mice and contact hypersensitivity in BALB/c mice. Ethanol administered by gavage for 5 days enhanced contact hypersensitivity in BALB/c mice. Ethanol administration with gavage also enhanced ACA of BALB/c mice. Ethanol did not affect mRNA expression of IFN-γ and IL-4, but did enhance IL-6, IL-10, and IL-18 mRNA expression. Histological evaluation revealed an absence of hepatic steatosis in mice administered ethanol by gavage for 5 days. In ethanol-administered mice, inflamed areas presented as lesions or a local extreme accumulation of mononuclear cells in the epidermis. These findings suggest that ethanol enhances the expression of inflammatory cytokines independently from T helper (Th)1/Th2 cytokine phenotypes, causing abnormalities in the epidermis resulting in exacerbated allergic reactivity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24953256</pmid><doi>10.1016/j.alcohol.2014.05.001</doi><tpages>8</tpages></addata></record> |
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subjects | Alcohol Allergies Allergy Anaphylaxis - immunology Animals Aqueous solutions Asthma Dermatitis Dermatitis, Atopic - chemically induced Dermatitis, Contact - etiology Diet Ethanol Ethanol - toxicity Experiments Female Hair Hypotheses Interferon-gamma Interleukin-10 Interleukin-4 Interleukin-6 Lymphocytes Mice, Inbred BALB C Olive oil Passive Cutaneous Anaphylaxis - immunology Permeability Psychiatry Skin Studies |
title | Low-dose ethanol aggravates allergic dermatitis in mice |
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