Improved chemosensitivity in cervical cancer to cisplatin: Synergistic activity of mahanine through STAT3 inhibition

Abstract Toxicity reduction of cisplatin is necessary for improved treatment of cancer. Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apo...

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Veröffentlicht in:	Cancer letters 2014-08, Vol.351 (1), p.81-90
Hauptverfasser:	Das, Ranjita, Bhattacharya, Kaushik, Samanta, Suman K, Pal, Bikas C, Mandal, Chitra
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antineoplastic Agents - pharmacology Apoptosis Cancer therapies Carbazoles - pharmacology Cell culture Cell Movement - drug effects Cell Survival - drug effects Cervical cancer Chemotherapy Cisplatin Cisplatin - pharmacology Cytotoxicity Drug Screening Assays, Antitumor Drug Synergism Female HeLa Cells Hematology, Oncology and Palliative Medicine Human papillomavirus Humans Inhibitory Concentration 50 Kinases Leukemia Lymphoma Mahanine Membrane Potential, Mitochondrial - drug effects Phosphorylation Protein Processing, Post-Translational Proteolysis Software STAT3 STAT3 Transcription Factor - metabolism Synergism Uterine Cervical Neoplasms - drug therapy
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