IgG4-related epididymo-orchitis associated with bladder cancer: possible involvement of BAFF/BAFF-R interaction in IgG4-related urogenital disease
Abstract We describe herein a patient who presented with immunoglobulin G4-related disease (IgG4-RD) involving the testis and prostate as well as the submandibular glands. Massive infiltration of IgG4-expressing plasma cells was observed in testis and prostate tissues. Serum concentrations of B cell...
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| Veröffentlicht in: | Modern rheumatology 2014-01, Vol.24 (1), p.188-194 |
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| creator | Migita, Kiyoshi Miyashita, Taiichiro Mizuno, Aya Jiuchi, Yuka Ito, Masahiro Matsuo, Manabu Izumi, Yasumori Takeoka, Atsushi Nishino, Ayako Hayashi, Mikio |
| description | Abstract
We describe herein a patient who presented with immunoglobulin G4-related disease (IgG4-RD) involving the testis and prostate as well as the submandibular glands. Massive infiltration of IgG4-expressing plasma cells was observed in testis and prostate tissues. Serum concentrations of B cell activating factor belonging to the tumor necrosis factor family (BAFF) were elevated in parallel with serum IgG4 concentrations, and infiltration of BAFF-receptor (BAFF-R)-expressing B cells and BAFF-expressing lymphoid cells was observed around the ectopic lymphoid foci in the affected urogenital tissues. To date, testicular involvement in a patient diagnosed with IgG4-RD had not been reported, making this the first reported case of IgG4-related epididymo-orchitis. These findings suggest that the immune mechanism underlying ectopic lymphoneogenesis in IgG4-RD may involve enhanced BAFF/BAFF-R interactions among lymphoid cells. |
| doi_str_mv | 10.3109/14397595.2013.852841 |
| format | Article |
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We describe herein a patient who presented with immunoglobulin G4-related disease (IgG4-RD) involving the testis and prostate as well as the submandibular glands. Massive infiltration of IgG4-expressing plasma cells was observed in testis and prostate tissues. Serum concentrations of B cell activating factor belonging to the tumor necrosis factor family (BAFF) were elevated in parallel with serum IgG4 concentrations, and infiltration of BAFF-receptor (BAFF-R)-expressing B cells and BAFF-expressing lymphoid cells was observed around the ectopic lymphoid foci in the affected urogenital tissues. To date, testicular involvement in a patient diagnosed with IgG4-RD had not been reported, making this the first reported case of IgG4-related epididymo-orchitis. These findings suggest that the immune mechanism underlying ectopic lymphoneogenesis in IgG4-RD may involve enhanced BAFF/BAFF-R interactions among lymphoid cells.</description><identifier>ISSN: 1439-7595</identifier><identifier>EISSN: 1439-7609</identifier><identifier>DOI: 10.3109/14397595.2013.852841</identifier><identifier>PMID: 24261777</identifier><language>eng</language><publisher>United States: Informa Healthcare</publisher><subject>Aged ; Autoimmune Diseases - complications ; Autoimmune Diseases - immunology ; B cell activating factor belonging to the tumor necrosis factor family ; B-Cell Activation Factor Receptor ; Cells ; Epididymo-orchitis ; Humans ; IgG4-related disease ; Immunoglobulin G - immunology ; Immunoglobulins ; Male ; Orchitis - complications ; Orchitis - immunology ; Plasma ; Prostate - immunology ; Prostatitis ; Testis - immunology ; Tissues ; TNF inhibitors ; Urinary Bladder Neoplasms - complications ; Urinary Bladder Neoplasms - immunology</subject><ispartof>Modern rheumatology, 2014-01, Vol.24 (1), p.188-194</ispartof><rights>2013 Japan College of Rheumatology 2013</rights><rights>Copyright Informa Healthcare Jan 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-d8068d162eb464e64dc526a9e7d84fbbbe8518151123ca5a65ed172f115593213</citedby><cites>FETCH-LOGICAL-c470t-d8068d162eb464e64dc526a9e7d84fbbbe8518151123ca5a65ed172f115593213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24261777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Migita, Kiyoshi</creatorcontrib><creatorcontrib>Miyashita, Taiichiro</creatorcontrib><creatorcontrib>Mizuno, Aya</creatorcontrib><creatorcontrib>Jiuchi, Yuka</creatorcontrib><creatorcontrib>Ito, Masahiro</creatorcontrib><creatorcontrib>Matsuo, Manabu</creatorcontrib><creatorcontrib>Izumi, Yasumori</creatorcontrib><creatorcontrib>Takeoka, Atsushi</creatorcontrib><creatorcontrib>Nishino, Ayako</creatorcontrib><creatorcontrib>Hayashi, Mikio</creatorcontrib><title>IgG4-related epididymo-orchitis associated with bladder cancer: possible involvement of BAFF/BAFF-R interaction in IgG4-related urogenital disease</title><title>Modern rheumatology</title><addtitle>Mod Rheumatol</addtitle><description>Abstract
We describe herein a patient who presented with immunoglobulin G4-related disease (IgG4-RD) involving the testis and prostate as well as the submandibular glands. Massive infiltration of IgG4-expressing plasma cells was observed in testis and prostate tissues. Serum concentrations of B cell activating factor belonging to the tumor necrosis factor family (BAFF) were elevated in parallel with serum IgG4 concentrations, and infiltration of BAFF-receptor (BAFF-R)-expressing B cells and BAFF-expressing lymphoid cells was observed around the ectopic lymphoid foci in the affected urogenital tissues. To date, testicular involvement in a patient diagnosed with IgG4-RD had not been reported, making this the first reported case of IgG4-related epididymo-orchitis. These findings suggest that the immune mechanism underlying ectopic lymphoneogenesis in IgG4-RD may involve enhanced BAFF/BAFF-R interactions among lymphoid cells.</description><subject>Aged</subject><subject>Autoimmune Diseases - complications</subject><subject>Autoimmune Diseases - immunology</subject><subject>B cell activating factor belonging to the tumor necrosis factor family</subject><subject>B-Cell Activation Factor Receptor</subject><subject>Cells</subject><subject>Epididymo-orchitis</subject><subject>Humans</subject><subject>IgG4-related disease</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulins</subject><subject>Male</subject><subject>Orchitis - complications</subject><subject>Orchitis - immunology</subject><subject>Plasma</subject><subject>Prostate - immunology</subject><subject>Prostatitis</subject><subject>Testis - immunology</subject><subject>Tissues</subject><subject>TNF inhibitors</subject><subject>Urinary Bladder Neoplasms - complications</subject><subject>Urinary Bladder Neoplasms - immunology</subject><issn>1439-7595</issn><issn>1439-7609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhiMEoqXwBghZ4sIlW09iJzEHUKnYUqkSEoKz5diTrisnXmyn1b4GT4zDdhHl0Itn5PnmH4__ongNdFUDFafAatFywVcVhXrV8apj8KQ4Xq7LtqHi6SHPzFHxIsYbSmsuOvG8OKpY1UDbtsfFr8vrC1YGdCqhIbi1xprd6Esf9MYmG4mK0Wv7p3pn04b0ThmDgWg1aQzvydbHaHuHxE633t3iiFMifiCfztbr0-Uov-VSwqB0sn7KOXkwcg7-GieblCPGRlQRXxbPBuUivrqPJ8WP9efv51_Kq68Xl-dnV6VmLU2l6WjTGWgq7FnDsGFG86pRAlvTsaHve-w4dMABqlorrhqOBtpqAOBc1BXUJ8W7ve42-J8zxiRHGzU6pyb0c5TAGqgZZfWCvv0PvfFzmPLrJHBGRZtBkSm2p3TInxJwkNtgRxV2EqhcPJMHz-Timdx7ltve3IvP_Yjmb9PBpAx83AN2GnwY1Z0Pzsikds6HIWQfbFzkHx3x4YHCBpVLG60C_rPIYwK_AQqXuRU</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Migita, Kiyoshi</creator><creator>Miyashita, Taiichiro</creator><creator>Mizuno, Aya</creator><creator>Jiuchi, Yuka</creator><creator>Ito, Masahiro</creator><creator>Matsuo, Manabu</creator><creator>Izumi, Yasumori</creator><creator>Takeoka, Atsushi</creator><creator>Nishino, Ayako</creator><creator>Hayashi, Mikio</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201401</creationdate><title>IgG4-related epididymo-orchitis associated with bladder cancer: possible involvement of BAFF/BAFF-R interaction in IgG4-related urogenital disease</title><author>Migita, Kiyoshi ; Miyashita, Taiichiro ; Mizuno, Aya ; Jiuchi, Yuka ; Ito, Masahiro ; Matsuo, Manabu ; Izumi, Yasumori ; Takeoka, Atsushi ; Nishino, Ayako ; Hayashi, Mikio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-d8068d162eb464e64dc526a9e7d84fbbbe8518151123ca5a65ed172f115593213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Autoimmune Diseases - complications</topic><topic>Autoimmune Diseases - immunology</topic><topic>B cell activating factor belonging to the tumor necrosis factor family</topic><topic>B-Cell Activation Factor Receptor</topic><topic>Cells</topic><topic>Epididymo-orchitis</topic><topic>Humans</topic><topic>IgG4-related disease</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulins</topic><topic>Male</topic><topic>Orchitis - complications</topic><topic>Orchitis - immunology</topic><topic>Plasma</topic><topic>Prostate - immunology</topic><topic>Prostatitis</topic><topic>Testis - immunology</topic><topic>Tissues</topic><topic>TNF inhibitors</topic><topic>Urinary Bladder Neoplasms - complications</topic><topic>Urinary Bladder Neoplasms - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Migita, Kiyoshi</creatorcontrib><creatorcontrib>Miyashita, Taiichiro</creatorcontrib><creatorcontrib>Mizuno, Aya</creatorcontrib><creatorcontrib>Jiuchi, Yuka</creatorcontrib><creatorcontrib>Ito, Masahiro</creatorcontrib><creatorcontrib>Matsuo, Manabu</creatorcontrib><creatorcontrib>Izumi, Yasumori</creatorcontrib><creatorcontrib>Takeoka, Atsushi</creatorcontrib><creatorcontrib>Nishino, Ayako</creatorcontrib><creatorcontrib>Hayashi, Mikio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Modern rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Migita, Kiyoshi</au><au>Miyashita, Taiichiro</au><au>Mizuno, Aya</au><au>Jiuchi, Yuka</au><au>Ito, Masahiro</au><au>Matsuo, Manabu</au><au>Izumi, Yasumori</au><au>Takeoka, Atsushi</au><au>Nishino, Ayako</au><au>Hayashi, Mikio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgG4-related epididymo-orchitis associated with bladder cancer: possible involvement of BAFF/BAFF-R interaction in IgG4-related urogenital disease</atitle><jtitle>Modern rheumatology</jtitle><addtitle>Mod Rheumatol</addtitle><date>2014-01</date><risdate>2014</risdate><volume>24</volume><issue>1</issue><spage>188</spage><epage>194</epage><pages>188-194</pages><issn>1439-7595</issn><eissn>1439-7609</eissn><abstract>Abstract
We describe herein a patient who presented with immunoglobulin G4-related disease (IgG4-RD) involving the testis and prostate as well as the submandibular glands. Massive infiltration of IgG4-expressing plasma cells was observed in testis and prostate tissues. Serum concentrations of B cell activating factor belonging to the tumor necrosis factor family (BAFF) were elevated in parallel with serum IgG4 concentrations, and infiltration of BAFF-receptor (BAFF-R)-expressing B cells and BAFF-expressing lymphoid cells was observed around the ectopic lymphoid foci in the affected urogenital tissues. To date, testicular involvement in a patient diagnosed with IgG4-RD had not been reported, making this the first reported case of IgG4-related epididymo-orchitis. These findings suggest that the immune mechanism underlying ectopic lymphoneogenesis in IgG4-RD may involve enhanced BAFF/BAFF-R interactions among lymphoid cells.</abstract><cop>United States</cop><pub>Informa Healthcare</pub><pmid>24261777</pmid><doi>10.3109/14397595.2013.852841</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Autoimmune Diseases - complications Autoimmune Diseases - immunology B cell activating factor belonging to the tumor necrosis factor family B-Cell Activation Factor Receptor Cells Epididymo-orchitis Humans IgG4-related disease Immunoglobulin G - immunology Immunoglobulins Male Orchitis - complications Orchitis - immunology Plasma Prostate - immunology Prostatitis Testis - immunology Tissues TNF inhibitors Urinary Bladder Neoplasms - complications Urinary Bladder Neoplasms - immunology |
| title | IgG4-related epididymo-orchitis associated with bladder cancer: possible involvement of BAFF/BAFF-R interaction in IgG4-related urogenital disease |
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