Differential expression and role of hyperglycemia induced oxidative stress in epigenetic regulation of [beta]1, [beta]2 and [beta]3-adrenergic receptors in retinal endothelial cells

Aberrant epigenetic profiles are concomitant with a spectrum of developmental defects and diseases. Role of methylation is an increasingly accepted factor in the pathophysiology of diabetes and its associated complications. This study aims to examine the correlation between oxidative stress and meth...

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Veröffentlicht in:	BMC medical genomics 2014-05, Vol.7
Hauptverfasser:	Safi, Sher Zaman, Qvist, Rajes, Yan, Gracie Ong Siok, Ismail, Ikram Shah Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Apoptosis Cell culture Complications and side effects Deoxyribonucleic acid Diabetes Diabetic retinopathy DNA DNA methylation Epigenetic inheritance Epigenetics Gene expression Genes Genetic aspects Glucose Hyperglycemia Kinases Oxidative stress Pathogenesis Phosphorylation Physiological aspects Proteins Risk factors Studies Type 2 diabetes
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