Preparation, Characterization, and Pharmacodynamics of Thermosensitive Liposomes Containing Docetaxel
A novel thermosensitive liposome (TL) containing docetaxel (DTX) was designed to enhance DTX-targeted delivery and antitumor effect. TL loading DTX (DTX-TL) were prepared by thin film hydration. The mean particle size of the liposomes was about 100 nm, and the drug entrapment efficiency was more tha...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 2014-07, Vol.103 (7), p.2177-2183 |
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| creator | Zhang, Hui Gong, Wei Wang, Zhi-Yuan Yuan, Shou-Jun Xie, Xiang-Yang Yang, Yan-Fang Yang, Yang Wang, Shan-Shan Yang, De-Xuan Xuan, Zi-Xue Mei, Xing-Guo |
| description | A novel thermosensitive liposome (TL) containing docetaxel (DTX) was designed to enhance DTX-targeted delivery and antitumor effect. TL loading DTX (DTX-TL) were prepared by thin film hydration. The mean particle size of the liposomes was about 100 nm, and the drug entrapment efficiency was more than 95%. The phase transition temperature of liposomes was about 42°C. In vitro drug release showed that drug released at 37°C was obviously less than that at 42°C. For in vivo experiments, the human breast tumor model was established by subcutaneous xenotransplantation on nude mice; liposomes and injection containing DTX were injected i.v. in nude mice, followed by exposure of the tumors to hyperthermia (HT) for 30 min after administration. The tumor inhibition ratio of DTX-TL group was significantly higher than the normal injection group. Combining TL with HT enhanced the delivery of DTX and thereby its antitumor effects. The liposomes reported in this paper could potentially produce viable clinical strategies for improved targeting and delivery of DTX for the treatment of breast cancer. |
| doi_str_mv | 10.1002/jps.24019 |
| format | Article |
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TL loading DTX (DTX-TL) were prepared by thin film hydration. The mean particle size of the liposomes was about 100 nm, and the drug entrapment efficiency was more than 95%. The phase transition temperature of liposomes was about 42°C. In vitro drug release showed that drug released at 37°C was obviously less than that at 42°C. For in vivo experiments, the human breast tumor model was established by subcutaneous xenotransplantation on nude mice; liposomes and injection containing DTX were injected i.v. in nude mice, followed by exposure of the tumors to hyperthermia (HT) for 30 min after administration. The tumor inhibition ratio of DTX-TL group was significantly higher than the normal injection group. Combining TL with HT enhanced the delivery of DTX and thereby its antitumor effects. The liposomes reported in this paper could potentially produce viable clinical strategies for improved targeting and delivery of DTX for the treatment of breast cancer.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.24019</identifier><identifier>PMID: 24846075</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; antitumor effect ; Calorimetry, Differential Scanning ; controlled release ; docetaxel ; Drug Carriers ; Drug Compounding - methods ; drug delivery systems ; Drug Liberation ; Female ; Humans ; hyperthermia ; Hyperthermia, Induced ; Liposomes ; MCF-7 Cells ; Mice, Nude ; nanotechnology ; Particle Size ; pharmacodynamics ; Taxoids - administration & dosage ; Taxoids - chemistry ; Taxoids - pharmacology ; Taxoids - therapeutic use ; thermosensitive ; thin film hydration ; Transition Temperature ; Xenograft Model Antitumor Assays</subject><ispartof>Journal of pharmaceutical sciences, 2014-07, Vol.103 (7), p.2177-2183</ispartof><rights>2014 Wiley Periodicals, Inc. and the American Pharmacists Association</rights><rights>2014 Wiley Periodicals, Inc. and the American Pharmacists Association.</rights><rights>Copyright © 2014 Wiley Periodicals, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3979-3da7c32b1689a3e27d72a63971bb03adc948d8dcd07f7b8009878901513c08c33</citedby><cites>FETCH-LOGICAL-c3979-3da7c32b1689a3e27d72a63971bb03adc948d8dcd07f7b8009878901513c08c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.24019$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.24019$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24846075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Gong, Wei</creatorcontrib><creatorcontrib>Wang, Zhi-Yuan</creatorcontrib><creatorcontrib>Yuan, Shou-Jun</creatorcontrib><creatorcontrib>Xie, Xiang-Yang</creatorcontrib><creatorcontrib>Yang, Yan-Fang</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Wang, Shan-Shan</creatorcontrib><creatorcontrib>Yang, De-Xuan</creatorcontrib><creatorcontrib>Xuan, Zi-Xue</creatorcontrib><creatorcontrib>Mei, Xing-Guo</creatorcontrib><title>Preparation, Characterization, and Pharmacodynamics of Thermosensitive Liposomes Containing Docetaxel</title><title>Journal of pharmaceutical sciences</title><addtitle>J Pharm Sci</addtitle><description>A novel thermosensitive liposome (TL) containing docetaxel (DTX) was designed to enhance DTX-targeted delivery and antitumor effect. TL loading DTX (DTX-TL) were prepared by thin film hydration. The mean particle size of the liposomes was about 100 nm, and the drug entrapment efficiency was more than 95%. The phase transition temperature of liposomes was about 42°C. In vitro drug release showed that drug released at 37°C was obviously less than that at 42°C. For in vivo experiments, the human breast tumor model was established by subcutaneous xenotransplantation on nude mice; liposomes and injection containing DTX were injected i.v. in nude mice, followed by exposure of the tumors to hyperthermia (HT) for 30 min after administration. The tumor inhibition ratio of DTX-TL group was significantly higher than the normal injection group. Combining TL with HT enhanced the delivery of DTX and thereby its antitumor effects. The liposomes reported in this paper could potentially produce viable clinical strategies for improved targeting and delivery of DTX for the treatment of breast cancer.</description><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>antitumor effect</subject><subject>Calorimetry, Differential Scanning</subject><subject>controlled release</subject><subject>docetaxel</subject><subject>Drug Carriers</subject><subject>Drug Compounding - methods</subject><subject>drug delivery systems</subject><subject>Drug Liberation</subject><subject>Female</subject><subject>Humans</subject><subject>hyperthermia</subject><subject>Hyperthermia, Induced</subject><subject>Liposomes</subject><subject>MCF-7 Cells</subject><subject>Mice, Nude</subject><subject>nanotechnology</subject><subject>Particle Size</subject><subject>pharmacodynamics</subject><subject>Taxoids - administration & dosage</subject><subject>Taxoids - chemistry</subject><subject>Taxoids - pharmacology</subject><subject>Taxoids - therapeutic use</subject><subject>thermosensitive</subject><subject>thin film hydration</subject><subject>Transition Temperature</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v2zAMhoVhxZpmO-wPFAZ2GlC3lGVb8rHI1i8EWIB1Z0GWmEVBLLmSkzX99dWapKf2JIJ89JJ4CPlK4ZwCFBfLPp4XJdDmAxnRqoC8Bso_klGaFTmryuaYnMS4BIAaquoTOS5KUdbAqxHBWcBeBTVY786yySKVesBgn_Yd5Uw2S91OaW-2TnVWx8zPs_sFhs5HdNEOdoPZ1PY--g5jNvFuUNZZ9zf74TUO6hFXn8nRXK0iftm_Y_Ln6uf95Caf_rq-nVxOc80a3uTMKK5Z0dJaNIphwQ0vVJ1GtG2BKaObUhhhtAE-560AaAQXDdCKMg1CMzYm33a5ffAPa4yDXPp1cGmlpBXjQkCylKjvO0oHH2PAueyD7VTYSgryv1CZhMoXoYk93Seu2w7NK3kwmICLHfDPrnD7fpK8m_0-RLLdD0wmNhaDjNqi02hsQD1I4-0bhzwDY-yRvw</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Zhang, Hui</creator><creator>Gong, Wei</creator><creator>Wang, Zhi-Yuan</creator><creator>Yuan, Shou-Jun</creator><creator>Xie, Xiang-Yang</creator><creator>Yang, Yan-Fang</creator><creator>Yang, Yang</creator><creator>Wang, Shan-Shan</creator><creator>Yang, De-Xuan</creator><creator>Xuan, Zi-Xue</creator><creator>Mei, Xing-Guo</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201407</creationdate><title>Preparation, Characterization, and Pharmacodynamics of Thermosensitive Liposomes Containing Docetaxel</title><author>Zhang, Hui ; Gong, Wei ; Wang, Zhi-Yuan ; Yuan, Shou-Jun ; Xie, Xiang-Yang ; Yang, Yan-Fang ; Yang, Yang ; Wang, Shan-Shan ; Yang, De-Xuan ; Xuan, Zi-Xue ; Mei, Xing-Guo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3979-3da7c32b1689a3e27d72a63971bb03adc948d8dcd07f7b8009878901513c08c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>antitumor effect</topic><topic>Calorimetry, Differential Scanning</topic><topic>controlled release</topic><topic>docetaxel</topic><topic>Drug Carriers</topic><topic>Drug Compounding - methods</topic><topic>drug delivery systems</topic><topic>Drug Liberation</topic><topic>Female</topic><topic>Humans</topic><topic>hyperthermia</topic><topic>Hyperthermia, Induced</topic><topic>Liposomes</topic><topic>MCF-7 Cells</topic><topic>Mice, Nude</topic><topic>nanotechnology</topic><topic>Particle Size</topic><topic>pharmacodynamics</topic><topic>Taxoids - administration & dosage</topic><topic>Taxoids - chemistry</topic><topic>Taxoids - pharmacology</topic><topic>Taxoids - therapeutic use</topic><topic>thermosensitive</topic><topic>thin film hydration</topic><topic>Transition Temperature</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Gong, Wei</creatorcontrib><creatorcontrib>Wang, Zhi-Yuan</creatorcontrib><creatorcontrib>Yuan, Shou-Jun</creatorcontrib><creatorcontrib>Xie, Xiang-Yang</creatorcontrib><creatorcontrib>Yang, Yan-Fang</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Wang, Shan-Shan</creatorcontrib><creatorcontrib>Yang, De-Xuan</creatorcontrib><creatorcontrib>Xuan, Zi-Xue</creatorcontrib><creatorcontrib>Mei, Xing-Guo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Hui</au><au>Gong, Wei</au><au>Wang, Zhi-Yuan</au><au>Yuan, Shou-Jun</au><au>Xie, Xiang-Yang</au><au>Yang, Yan-Fang</au><au>Yang, Yang</au><au>Wang, Shan-Shan</au><au>Yang, De-Xuan</au><au>Xuan, Zi-Xue</au><au>Mei, Xing-Guo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation, Characterization, and Pharmacodynamics of Thermosensitive Liposomes Containing Docetaxel</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J Pharm Sci</addtitle><date>2014-07</date><risdate>2014</risdate><volume>103</volume><issue>7</issue><spage>2177</spage><epage>2183</epage><pages>2177-2183</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>A novel thermosensitive liposome (TL) containing docetaxel (DTX) was designed to enhance DTX-targeted delivery and antitumor effect. TL loading DTX (DTX-TL) were prepared by thin film hydration. The mean particle size of the liposomes was about 100 nm, and the drug entrapment efficiency was more than 95%. The phase transition temperature of liposomes was about 42°C. In vitro drug release showed that drug released at 37°C was obviously less than that at 42°C. For in vivo experiments, the human breast tumor model was established by subcutaneous xenotransplantation on nude mice; liposomes and injection containing DTX were injected i.v. in nude mice, followed by exposure of the tumors to hyperthermia (HT) for 30 min after administration. The tumor inhibition ratio of DTX-TL group was significantly higher than the normal injection group. Combining TL with HT enhanced the delivery of DTX and thereby its antitumor effects. The liposomes reported in this paper could potentially produce viable clinical strategies for improved targeting and delivery of DTX for the treatment of breast cancer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24846075</pmid><doi>10.1002/jps.24019</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use antitumor effect Calorimetry, Differential Scanning controlled release docetaxel Drug Carriers Drug Compounding - methods drug delivery systems Drug Liberation Female Humans hyperthermia Hyperthermia, Induced Liposomes MCF-7 Cells Mice, Nude nanotechnology Particle Size pharmacodynamics Taxoids - administration & dosage Taxoids - chemistry Taxoids - pharmacology Taxoids - therapeutic use thermosensitive thin film hydration Transition Temperature Xenograft Model Antitumor Assays |
| title | Preparation, Characterization, and Pharmacodynamics of Thermosensitive Liposomes Containing Docetaxel |
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