Synthesis of Oligomeric Mannosides and Their Structure-Binding Relationship with ConcanavalinA

Small glycodendrimers with [alpha]-mannosyl ligands were synthesized by using copper-catalyzed azide-alkyne coupling chemistry and some of these molecules were used as multivalent ligands to study the induction of concanavalinA (ConA) precipitation. The results showed that the monovalent mannose lig...

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Veröffentlicht in:	Chemistry, an Asian journal an Asian journal, 2014-07, Vol.9 (7), p.1786
Hauptverfasser:	Li, Chen-Wei, Hon, Kai-Wei, Ghosh, Bhaswati, Li, Po-Han, Lin, Hsien-Ya, Chan, Po-Han, Lin, Chun-Hung, Chen, Yu-Chie, Mong, Kwok-Kong Tony
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Schlagworte:	Chemistry Ligands
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container_title	Chemistry, an Asian journal
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creator	Li, Chen-Wei Hon, Kai-Wei Ghosh, Bhaswati Li, Po-Han Lin, Hsien-Ya Chan, Po-Han Lin, Chun-Hung Chen, Yu-Chie Mong, Kwok-Kong Tony
description	Small glycodendrimers with [alpha]-mannosyl ligands were synthesized by using copper-catalyzed azide-alkyne coupling chemistry and some of these molecules were used as multivalent ligands to study the induction of concanavalinA (ConA) precipitation. The results showed that the monovalent mannose ligand could induce the precipitation of ConA. This unexpected finding initiated a series of studies to characterize the molecular basis of the ligand-lectin interaction. The atypical precipitation is found to be specific to the mannose, fluorescein moiety (FITC), and ConA. Apparently the mannose ligand binds to ConA through hydrogen-bonding interactions, whereas the binding of FITC is mediated by hydrophobic forces. [PUBLICATION ABSTRACT]
doi_str_mv	10.1002/asia.201402029
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language	eng
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subjects	Chemistry Ligands
title	Synthesis of Oligomeric Mannosides and Their Structure-Binding Relationship with ConcanavalinA
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