Biodistribution and Pharmacokinetics of Dapivirine-Loaded Nanoparticles after Vaginal Delivery in Mice

ABSTRACT Purpose To assess the potential of polymeric nanoparticles (NPs) to affect the genital distribution and local and systemic pharmacokinetics (PK) of the anti-HIV microbicide drug candidate dapivirine after vaginal delivery. Methods Dapivirine-loaded, poly(ethylene oxide)-coated poly(epsilon-...

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Veröffentlicht in:	Pharmaceutical research 2014-07, Vol.31 (7), p.1834-1845
Hauptverfasser:	das Neves, José, Araújo, Francisca, Andrade, Fernanda, Amiji, Mansoor, Bahia, Maria Fernanda, Sarmento, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravaginal Animal reproduction Animals Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Female HIV Infections - drug therapy HIV Reverse Transcriptase - administration & dosage HIV Reverse Transcriptase - pharmacokinetics Kinetics Medical Law Mice Nanoparticles Nanoparticles - analysis Nanoparticles - metabolism Pharmacology Pharmacology/Toxicology Pharmacy Polyesters - analysis Polyesters - metabolism Pyrimidines - administration & dosage Pyrimidines - pharmacokinetics Research Paper Rodents Tissue Distribution Vagina - metabolism
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