Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion

The subthalamic nucleus (STN) is a key area of the basal ganglia circuitry regulating movement. We identified a subpopulation of neurons within this structure that coexpresses Vglut2 and Pitx2 , and by conditional targeting of this subpopulation we reduced Vglut2 expression levels in the STN by 40%,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-05, Vol.111 (21), p.7837-7842
Hauptverfasser:	Schweizer, Nadine, Pupe, Stéfano, Arvidsson, Emma, Nordenankar, Karin, Smith-Anttila, Casey J. A., Mahmoudi, Souha, Andrén, Anna, Dumas, Sylvie, Rajagopalan, Aparna, Lévesque, Daniel, Leão, Richardson N., Wallén-Mackenzie, ÅÅsa
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects Animal cognition Animals Behavioral neuroscience Biological Sciences Cells cognition deep brain stimulation dopamine Dopamine - metabolism Excitatory Postsynaptic Potentials - physiology gait ganglia Gene expression glutamic acid Glutamic Acid - metabolism Homeobox Protein PITX2 Homeodomain Proteins - metabolism Hyperkinesis - etiology Hyperkinesis - metabolism Immunohistochemistry In Situ Hybridization knockout mutants Lesions Locomotion Maze Learning - physiology Mental stimulation Messenger RNA Mice Mice, Knockout Neurons optogenetics Parkinson disease Reverse Transcriptase Polymerase Chain Reaction Rodents stand basal area striatum Subthalamic nucleus Subthalamic Nucleus - metabolism Supernova remnants Synaptic Transmission - physiology Transcription Factors - metabolism Vesicular Glutamate Transport Protein 2 - metabolism vesicular transporter
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