Genetic variants of Adam17 differentially regulate TGF[Beta] signaling to modify vascular pathology in mice and humans

Outcome of TGFα1 signaling is context dependent and differs between individuals due to germ-line genetic variation. To explore innate genetic variants that determine differential outcome of reduced TGFβ1 signaling, we dissected the modifier locus Tgfbm3, on mouse chromosome 12. On a NIH/OlaHsd genet...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-05, Vol.111 (21), p.7723
Hauptverfasser:	Kawasaki, Kyoko, Freimuth, Julia, Meyer, Dominique S, Lee, Marie M, Tochimoto-Okamoto, Akiko, Benzinou, Michael, Clermont, Frederic F, Wu, Gloria, Roy, Ritu, Letteboer, Tom GW, van Amstel, Johannes Kristian Ploos, Giraud, Sophie, Dupuis-Girod, Sophie, Lesca, Gaeten, Westermann, Cornelius JJ, Coffey, Robert J, Akhurst, Rosemary J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Angiogenesis Cells Genetics Haplotypes Pathology Rodents Signal transduction
Online-Zugang:	Volltext
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