Adverse drug reactions in an emergency medical dispatching centre
Purpose The purpose of this study is to assess the incidence of adverse drug reactions (ADR) leading to call an emergency medical dispatching centre. Methods A prospective, observational, monocentric clinical study performed over a 2-year period (2011–2012) in a French prehospital emergency dispatch...
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| Veröffentlicht in: | European journal of clinical pharmacology 2014-07, Vol.70 (7), p.881-887 |
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| container_title | European journal of clinical pharmacology |
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| creator | Dehours, E. Bounes, V. Bagheri, H. Vallé, B. Ducassé, J. L. Montastruc, J. L. |
| description | Purpose
The purpose of this study is to assess the incidence of adverse drug reactions (ADR) leading to call an emergency medical dispatching centre.
Methods
A prospective, observational, monocentric clinical study performed over a 2-year period (2011–2012) in a French prehospital emergency dispatching centre, the Service d'Aide Médicale Urgente (SAMU) covering 1,156,000 inhabitants. All adult patients (age ≥ 18) who called for any cause were included. We created an electronic trigger ‘iatrogenic event’ implemented by the dispatching physician for each suspected case of ADR, then we completed the analyses of all the cases with a chief complain represented in more than 1 % of the triggered cases. The primary outcome variable was the occurrence of any possible ADR. We then used the French method of causal relationship assessment.
Results
The SAMU dispatched 339,915 calls during the study. In total, 1,467 ADRs were identified, representing 0.95 % (CI 95 % 0.90–1.00 %) of cases. ADRs were as serious (SADR) in 51.06 % (CI 95 % 48.45–53.67 %) of cases. The major ADR observed was haemorrhage, (42.81 % (CI 95 % 40.62–45.00 %),
n
= 628) followed by allergy, hypoglycaemia, vomiting, dizziness and drowsiness. The class of drugs most frequently involved was antithrombotic (43.69 % (CI 95 % 41.45–45.93 %),
n
= 641), followed by insulin (17.98 % (CI 95 %:17.06–18.90 %),
n
= 264).
Conclusions
Emergency calls concerning ADRs were estimated as 9/1,000, and one out of two is serious. |
| doi_str_mv | 10.1007/s00228-014-1685-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1534733666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3331516891</sourcerecordid><originalsourceid>FETCH-LOGICAL-c435t-4383e3c03ae9b3b415d4bee27bdd3b31038bd144fc0328c28afc71874c3788633</originalsourceid><addsrcrecordid>eNp1kMtOwzAQRS0EoqXwAWxQJMQy4Mk4ibOsKl5SJTawthxnElK1brETpPw9rlIeG1azmHPncRi7BH4LnOd3nvMkkTEHEUMm03g4YlMQmMTABRyzKecIcVbkfMLOvF9xDmnB8ZRNEpEXUhYwZfN59UnOU1S5vokcadO1W-uj1kbaRrQh15A1Q7ShqjV6HVWt3-nOvLe2iQzZztE5O6n12tPFoc7Y28P96-IpXr48Pi_my9gITLtYoERCw1FTUWIpIK1ESZTkZVVhicBRlhUIUQckkSaRujY5yFwYzKXMEGfsepy7c9uPnnynVtve2bBSQYoiR8yyLFAwUsZtvXdUq51rN9oNCrjaS1OjNBWkqb00NYTM1WFyX4Y_fxLflgJwcwC0DxJqp61p_S8n01QWcn9iMnI-tGxD7s-J_27_Aoxzg6w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1534733666</pqid></control><display><type>article</type><title>Adverse drug reactions in an emergency medical dispatching centre</title><source>MEDLINE</source><source>Springer Journals</source><creator>Dehours, E. ; Bounes, V. ; Bagheri, H. ; Vallé, B. ; Ducassé, J. L. ; Montastruc, J. L.</creator><creatorcontrib>Dehours, E. ; Bounes, V. ; Bagheri, H. ; Vallé, B. ; Ducassé, J. L. ; Montastruc, J. L.</creatorcontrib><description>Purpose
The purpose of this study is to assess the incidence of adverse drug reactions (ADR) leading to call an emergency medical dispatching centre.
Methods
A prospective, observational, monocentric clinical study performed over a 2-year period (2011–2012) in a French prehospital emergency dispatching centre, the Service d'Aide Médicale Urgente (SAMU) covering 1,156,000 inhabitants. All adult patients (age ≥ 18) who called for any cause were included. We created an electronic trigger ‘iatrogenic event’ implemented by the dispatching physician for each suspected case of ADR, then we completed the analyses of all the cases with a chief complain represented in more than 1 % of the triggered cases. The primary outcome variable was the occurrence of any possible ADR. We then used the French method of causal relationship assessment.
Results
The SAMU dispatched 339,915 calls during the study. In total, 1,467 ADRs were identified, representing 0.95 % (CI 95 % 0.90–1.00 %) of cases. ADRs were as serious (SADR) in 51.06 % (CI 95 % 48.45–53.67 %) of cases. The major ADR observed was haemorrhage, (42.81 % (CI 95 % 40.62–45.00 %),
n
= 628) followed by allergy, hypoglycaemia, vomiting, dizziness and drowsiness. The class of drugs most frequently involved was antithrombotic (43.69 % (CI 95 % 41.45–45.93 %),
n
= 641), followed by insulin (17.98 % (CI 95 %:17.06–18.90 %),
n
= 264).
Conclusions
Emergency calls concerning ADRs were estimated as 9/1,000, and one out of two is serious.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s00228-014-1685-y</identifier><identifier>PMID: 24798891</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Drug therapy ; Drug-Related Side Effects and Adverse Reactions - epidemiology ; Drug-Related Side Effects and Adverse Reactions - therapy ; Emergency medical care ; Emergency Medical Services ; Female ; France - epidemiology ; Humans ; Iatrogenic Disease ; Incidence ; Male ; Medical sciences ; Middle Aged ; Pharmacoepidemiology and Prescription ; Pharmacology. Drug treatments ; Pharmacology/Toxicology ; Prospective Studies ; Side effects ; Telephone ; Time Factors</subject><ispartof>European journal of clinical pharmacology, 2014-07, Vol.70 (7), p.881-887</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-4383e3c03ae9b3b415d4bee27bdd3b31038bd144fc0328c28afc71874c3788633</citedby><cites>FETCH-LOGICAL-c435t-4383e3c03ae9b3b415d4bee27bdd3b31038bd144fc0328c28afc71874c3788633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00228-014-1685-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00228-014-1685-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28558983$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24798891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dehours, E.</creatorcontrib><creatorcontrib>Bounes, V.</creatorcontrib><creatorcontrib>Bagheri, H.</creatorcontrib><creatorcontrib>Vallé, B.</creatorcontrib><creatorcontrib>Ducassé, J. L.</creatorcontrib><creatorcontrib>Montastruc, J. L.</creatorcontrib><title>Adverse drug reactions in an emergency medical dispatching centre</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><addtitle>Eur J Clin Pharmacol</addtitle><description>Purpose
The purpose of this study is to assess the incidence of adverse drug reactions (ADR) leading to call an emergency medical dispatching centre.
Methods
A prospective, observational, monocentric clinical study performed over a 2-year period (2011–2012) in a French prehospital emergency dispatching centre, the Service d'Aide Médicale Urgente (SAMU) covering 1,156,000 inhabitants. All adult patients (age ≥ 18) who called for any cause were included. We created an electronic trigger ‘iatrogenic event’ implemented by the dispatching physician for each suspected case of ADR, then we completed the analyses of all the cases with a chief complain represented in more than 1 % of the triggered cases. The primary outcome variable was the occurrence of any possible ADR. We then used the French method of causal relationship assessment.
Results
The SAMU dispatched 339,915 calls during the study. In total, 1,467 ADRs were identified, representing 0.95 % (CI 95 % 0.90–1.00 %) of cases. ADRs were as serious (SADR) in 51.06 % (CI 95 % 48.45–53.67 %) of cases. The major ADR observed was haemorrhage, (42.81 % (CI 95 % 40.62–45.00 %),
n
= 628) followed by allergy, hypoglycaemia, vomiting, dizziness and drowsiness. The class of drugs most frequently involved was antithrombotic (43.69 % (CI 95 % 41.45–45.93 %),
n
= 641), followed by insulin (17.98 % (CI 95 %:17.06–18.90 %),
n
= 264).
Conclusions
Emergency calls concerning ADRs were estimated as 9/1,000, and one out of two is serious.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Drug therapy</subject><subject>Drug-Related Side Effects and Adverse Reactions - epidemiology</subject><subject>Drug-Related Side Effects and Adverse Reactions - therapy</subject><subject>Emergency medical care</subject><subject>Emergency Medical Services</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Humans</subject><subject>Iatrogenic Disease</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacoepidemiology and Prescription</subject><subject>Pharmacology. Drug treatments</subject><subject>Pharmacology/Toxicology</subject><subject>Prospective Studies</subject><subject>Side effects</subject><subject>Telephone</subject><subject>Time Factors</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMtOwzAQRS0EoqXwAWxQJMQy4Mk4ibOsKl5SJTawthxnElK1brETpPw9rlIeG1azmHPncRi7BH4LnOd3nvMkkTEHEUMm03g4YlMQmMTABRyzKecIcVbkfMLOvF9xDmnB8ZRNEpEXUhYwZfN59UnOU1S5vokcadO1W-uj1kbaRrQh15A1Q7ShqjV6HVWt3-nOvLe2iQzZztE5O6n12tPFoc7Y28P96-IpXr48Pi_my9gITLtYoERCw1FTUWIpIK1ESZTkZVVhicBRlhUIUQckkSaRujY5yFwYzKXMEGfsepy7c9uPnnynVtve2bBSQYoiR8yyLFAwUsZtvXdUq51rN9oNCrjaS1OjNBWkqb00NYTM1WFyX4Y_fxLflgJwcwC0DxJqp61p_S8n01QWcn9iMnI-tGxD7s-J_27_Aoxzg6w</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Dehours, E.</creator><creator>Bounes, V.</creator><creator>Bagheri, H.</creator><creator>Vallé, B.</creator><creator>Ducassé, J. L.</creator><creator>Montastruc, J. L.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20140701</creationdate><title>Adverse drug reactions in an emergency medical dispatching centre</title><author>Dehours, E. ; Bounes, V. ; Bagheri, H. ; Vallé, B. ; Ducassé, J. L. ; Montastruc, J. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-4383e3c03ae9b3b415d4bee27bdd3b31038bd144fc0328c28afc71874c3788633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Drug therapy</topic><topic>Drug-Related Side Effects and Adverse Reactions - epidemiology</topic><topic>Drug-Related Side Effects and Adverse Reactions - therapy</topic><topic>Emergency medical care</topic><topic>Emergency Medical Services</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Humans</topic><topic>Iatrogenic Disease</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacoepidemiology and Prescription</topic><topic>Pharmacology. Drug treatments</topic><topic>Pharmacology/Toxicology</topic><topic>Prospective Studies</topic><topic>Side effects</topic><topic>Telephone</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dehours, E.</creatorcontrib><creatorcontrib>Bounes, V.</creatorcontrib><creatorcontrib>Bagheri, H.</creatorcontrib><creatorcontrib>Vallé, B.</creatorcontrib><creatorcontrib>Ducassé, J. L.</creatorcontrib><creatorcontrib>Montastruc, J. L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dehours, E.</au><au>Bounes, V.</au><au>Bagheri, H.</au><au>Vallé, B.</au><au>Ducassé, J. L.</au><au>Montastruc, J. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse drug reactions in an emergency medical dispatching centre</atitle><jtitle>European journal of clinical pharmacology</jtitle><stitle>Eur J Clin Pharmacol</stitle><addtitle>Eur J Clin Pharmacol</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>70</volume><issue>7</issue><spage>881</spage><epage>887</epage><pages>881-887</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Purpose
The purpose of this study is to assess the incidence of adverse drug reactions (ADR) leading to call an emergency medical dispatching centre.
Methods
A prospective, observational, monocentric clinical study performed over a 2-year period (2011–2012) in a French prehospital emergency dispatching centre, the Service d'Aide Médicale Urgente (SAMU) covering 1,156,000 inhabitants. All adult patients (age ≥ 18) who called for any cause were included. We created an electronic trigger ‘iatrogenic event’ implemented by the dispatching physician for each suspected case of ADR, then we completed the analyses of all the cases with a chief complain represented in more than 1 % of the triggered cases. The primary outcome variable was the occurrence of any possible ADR. We then used the French method of causal relationship assessment.
Results
The SAMU dispatched 339,915 calls during the study. In total, 1,467 ADRs were identified, representing 0.95 % (CI 95 % 0.90–1.00 %) of cases. ADRs were as serious (SADR) in 51.06 % (CI 95 % 48.45–53.67 %) of cases. The major ADR observed was haemorrhage, (42.81 % (CI 95 % 40.62–45.00 %),
n
= 628) followed by allergy, hypoglycaemia, vomiting, dizziness and drowsiness. The class of drugs most frequently involved was antithrombotic (43.69 % (CI 95 % 41.45–45.93 %),
n
= 641), followed by insulin (17.98 % (CI 95 %:17.06–18.90 %),
n
= 264).
Conclusions
Emergency calls concerning ADRs were estimated as 9/1,000, and one out of two is serious.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24798891</pmid><doi>10.1007/s00228-014-1685-y</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 2014-07, Vol.70 (7), p.881-887 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| source | MEDLINE; Springer Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomedical and Life Sciences Biomedicine Drug therapy Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - therapy Emergency medical care Emergency Medical Services Female France - epidemiology Humans Iatrogenic Disease Incidence Male Medical sciences Middle Aged Pharmacoepidemiology and Prescription Pharmacology. Drug treatments Pharmacology/Toxicology Prospective Studies Side effects Telephone Time Factors |
| title | Adverse drug reactions in an emergency medical dispatching centre |
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