Synthesis of Oxa-B-Ring Analogs of Colchicine through Rh-Catalyzed Intramolecular [5+2] Cycloaddition

A synthetic approach towards (5R)‐5‐methyl‐6‐oxa‐desacetamido colchicine as a conformationally defined non‐natural colchicine analog with a modified B‐ring was undertaken. The synthetic strategy was based on a Rh‐catalyzed cascade reaction involving a [5+2] cycloaddition of a carbonyl ylide intermed...

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