A case of ovarian endometrioid adenofibroma of borderline malignancy: Evidence for estrogen-producing tumor

A case of ovarian endometrioid adenofibroma of borderline malignancy with an increased serum estradiol level, which rapidly disappeared after removal of the tumor, is reported. Vaginal cytologic analysis showed estrogenic effects, and endometrial cystic glandular hyperplasia was thought to be the re...

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Veröffentlicht in:International journal of clinical oncology 1998-02, Vol.3 (1), p.41-43
Hauptverfasser: Miyagi, Etsuko, Hirahara, Fumiki, Inayama, Yoshiaki, Gorai, Itsuo, Yamaguchi, Hajime, Nakazawa, Tsuneo, Nagashima, Yoji, Nakatani, Yukio, Minaguchi, Hiroshi, Kitamura, Hitoshi
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container_end_page 43
container_issue 1
container_start_page 41
container_title International journal of clinical oncology
container_volume 3
creator Miyagi, Etsuko
Hirahara, Fumiki
Inayama, Yoshiaki
Gorai, Itsuo
Yamaguchi, Hajime
Nakazawa, Tsuneo
Nagashima, Yoji
Nakatani, Yukio
Minaguchi, Hiroshi
Kitamura, Hitoshi
description A case of ovarian endometrioid adenofibroma of borderline malignancy with an increased serum estradiol level, which rapidly disappeared after removal of the tumor, is reported. Vaginal cytologic analysis showed estrogenic effects, and endometrial cystic glandular hyperplasia was thought to be the reason for genital bleeding. To determine the origin of estradiol production in the tumor, stromal cells were enzymatically isolated from the tumor and cultured in vitro. Estradiol levels in the cultured media increased in parallel with cell growth. This is the first report showing estrogen secretion from stromal cells in an ovarian endometrioid adenofibroma.[PUBLICATION ABSTRACT]
doi_str_mv 10.1007/BF02490101
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subjects Estrogens
Ovarian cancer
title A case of ovarian endometrioid adenofibroma of borderline malignancy: Evidence for estrogen-producing tumor
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