Cutaneous adverse drug reactions in a hospital-based Chinese population
Summary Background. Cutaneous adverse drug reactions (CADRs) are common skin adverse reactions associated with drugs. Aim. To assess recent trends in CADRs and the drugs associated with them, using data from the past 5 years in the largest single database available on a hospital‐based population i...
Gespeichert in:
| Veröffentlicht in: | Clinical and experimental dermatology 2011-03, Vol.36 (2), p.135-141 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 141 |
|---|---|
| container_issue | 2 |
| container_start_page | 135 |
| container_title | Clinical and experimental dermatology |
| container_volume | 36 |
| creator | Huang, H.-Y. Luo, X.-Q. Chan, L.-S. Cao, Z.-H. Sun, X.-F. Xu, J.-H. |
| description | Summary
Background. Cutaneous adverse drug reactions (CADRs) are common skin adverse reactions associated with drugs.
Aim. To assess recent trends in CADRs and the drugs associated with them, using data from the past 5 years in the largest single database available on a hospital‐based population in China.
Methods. All clinical records of inpatients admitted with a diagnosis of CADR to the Dermatology Ward, Huashan Hospital from January 2004 to December 2008 were retrospectively studied.
Results. In the 734 patients, the three most common types of CADRs were nonsevere reactions, erythema multiforme (EM)‐like eruptions (n = 255), urticaria (n = 192) and exanthematous reactions (n = 159), followed by three severe reactions: Stevens–Johnson syndrome (n = 58), toxic epidermal necrolysis (n = 29) and exfoliative dermatitis (n = 22). The most common single drug associated with the development of all drug eruptions was allopurinol, followed by amoxicillin, cephalosporins, antiepileptic agents and antipyretic/analgesic agents. However, the most common single drugs associated with severe reactions were antiepileptic agents, followed by allopurinol, antipyretic/analgesic agents and cephalosporins. In contrast to patients with nonsevere reactions, patients with severe reactions were more likely to be male (P |
| doi_str_mv | 10.1111/j.1365-2230.2010.03922.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1529527729</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3317437011</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4642-1cef55cee432c3a4c114d12d2cfb827e9fd5b6fc46f571227bb0dd43a7da5ef43</originalsourceid><addsrcrecordid>eNqNkMFu1DAQhq2qiC5bXqGKhDhmscdxnBw4VKHdFq3gQlWJi-XYY5olTVI7ge3b47DLcq0vtsbfPzP6CEkYXbF4PmxXjOciBeB0BTRWKS8BVrsTsjh-nJIF5VSmecmLM_ImhC2ljDMpXpMzoJIXHGBB1tU06g77KSTa_kIfMLF--pF41GZs-i4kTZfo5KEPQzPqNq11QJtUD02HER36YWr1zJ2TV063Ad8e7iW5u776Vt2km6_r2-pyk5oszyBlBp0QBjHjYLjODGOZZWDBuLoAiaWzos5dhJ2QDEDWNbU241paLdBlfEne7fsOvn-aMIxq20--iyMVE1AKkBLKSBV7yvg-BI9ODb551P5ZMapmg2qrZlFqFqVmg-qvQbWL0YvDgKl-RHsM_lMWgfcHQAejW-d1Z5rwn-NldBzRJfm45343LT6_eAFVXX2aXzGf7vNNGHF3zGv_U-WSS6Huv6xVsVlv7unn7-qa_wH3sZsn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1529527729</pqid></control><display><type>article</type><title>Cutaneous adverse drug reactions in a hospital-based Chinese population</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Huang, H.-Y. ; Luo, X.-Q. ; Chan, L.-S. ; Cao, Z.-H. ; Sun, X.-F. ; Xu, J.-H.</creator><creatorcontrib>Huang, H.-Y. ; Luo, X.-Q. ; Chan, L.-S. ; Cao, Z.-H. ; Sun, X.-F. ; Xu, J.-H.</creatorcontrib><description>Summary
Background. Cutaneous adverse drug reactions (CADRs) are common skin adverse reactions associated with drugs.
Aim. To assess recent trends in CADRs and the drugs associated with them, using data from the past 5 years in the largest single database available on a hospital‐based population in China.
Methods. All clinical records of inpatients admitted with a diagnosis of CADR to the Dermatology Ward, Huashan Hospital from January 2004 to December 2008 were retrospectively studied.
Results. In the 734 patients, the three most common types of CADRs were nonsevere reactions, erythema multiforme (EM)‐like eruptions (n = 255), urticaria (n = 192) and exanthematous reactions (n = 159), followed by three severe reactions: Stevens–Johnson syndrome (n = 58), toxic epidermal necrolysis (n = 29) and exfoliative dermatitis (n = 22). The most common single drug associated with the development of all drug eruptions was allopurinol, followed by amoxicillin, cephalosporins, antiepileptic agents and antipyretic/analgesic agents. However, the most common single drugs associated with severe reactions were antiepileptic agents, followed by allopurinol, antipyretic/analgesic agents and cephalosporins. In contrast to patients with nonsevere reactions, patients with severe reactions were more likely to be male (P < 0.001) and to have a greater mean age of onset (P < 0.001), a longer latency period (P < 0.001) and a longer duration of hospitalization (P < 0.001).
Conclusion. In contrast to previous studies, we found allopurinol to be the most common single drug associated with CADRs followed by antibiotics (amoxicillin and cephalosporins), and antiepileptic, especially carbamazepine. A higher incidence of EM‐like eruptions and urticaria was also seen.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/j.1365-2230.2010.03922.x</identifier><identifier>PMID: 20738322</identifier><identifier>CODEN: CEDEDE</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Allopurinol - adverse effects ; Analgesics ; Analgesics - adverse effects ; Anti-Bacterial Agents - adverse effects ; Anticonvulsants - adverse effects ; Biological and medical sciences ; Child ; China - epidemiology ; Dermatology ; Drug Eruptions - epidemiology ; Drug Eruptions - etiology ; Erythema Multiforme - chemically induced ; Erythema Multiforme - epidemiology ; Exanthema - chemically induced ; Exanthema - epidemiology ; Female ; Gout Suppressants - adverse effects ; Hospitalization ; Humans ; Length of Stay - statistics & numerical data ; Male ; Medical sciences ; Middle Aged ; Pharmaceutical industry ; Retrospective Studies ; Sex Factors ; Time Factors ; Urticaria - chemically induced ; Urticaria - epidemiology ; Young Adult</subject><ispartof>Clinical and experimental dermatology, 2011-03, Vol.36 (2), p.135-141</ispartof><rights>2010 The Author(s). © 2010 British Association of Dermatologists</rights><rights>2015 INIST-CNRS</rights><rights>2010 The Author(s). © 2010 British Association of Dermatologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4642-1cef55cee432c3a4c114d12d2cfb827e9fd5b6fc46f571227bb0dd43a7da5ef43</citedby><cites>FETCH-LOGICAL-c4642-1cef55cee432c3a4c114d12d2cfb827e9fd5b6fc46f571227bb0dd43a7da5ef43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23917538$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20738322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, H.-Y.</creatorcontrib><creatorcontrib>Luo, X.-Q.</creatorcontrib><creatorcontrib>Chan, L.-S.</creatorcontrib><creatorcontrib>Cao, Z.-H.</creatorcontrib><creatorcontrib>Sun, X.-F.</creatorcontrib><creatorcontrib>Xu, J.-H.</creatorcontrib><title>Cutaneous adverse drug reactions in a hospital-based Chinese population</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Background. Cutaneous adverse drug reactions (CADRs) are common skin adverse reactions associated with drugs.
Aim. To assess recent trends in CADRs and the drugs associated with them, using data from the past 5 years in the largest single database available on a hospital‐based population in China.
Methods. All clinical records of inpatients admitted with a diagnosis of CADR to the Dermatology Ward, Huashan Hospital from January 2004 to December 2008 were retrospectively studied.
Results. In the 734 patients, the three most common types of CADRs were nonsevere reactions, erythema multiforme (EM)‐like eruptions (n = 255), urticaria (n = 192) and exanthematous reactions (n = 159), followed by three severe reactions: Stevens–Johnson syndrome (n = 58), toxic epidermal necrolysis (n = 29) and exfoliative dermatitis (n = 22). The most common single drug associated with the development of all drug eruptions was allopurinol, followed by amoxicillin, cephalosporins, antiepileptic agents and antipyretic/analgesic agents. However, the most common single drugs associated with severe reactions were antiepileptic agents, followed by allopurinol, antipyretic/analgesic agents and cephalosporins. In contrast to patients with nonsevere reactions, patients with severe reactions were more likely to be male (P < 0.001) and to have a greater mean age of onset (P < 0.001), a longer latency period (P < 0.001) and a longer duration of hospitalization (P < 0.001).
Conclusion. In contrast to previous studies, we found allopurinol to be the most common single drug associated with CADRs followed by antibiotics (amoxicillin and cephalosporins), and antiepileptic, especially carbamazepine. A higher incidence of EM‐like eruptions and urticaria was also seen.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Allopurinol - adverse effects</subject><subject>Analgesics</subject><subject>Analgesics - adverse effects</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anticonvulsants - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>China - epidemiology</subject><subject>Dermatology</subject><subject>Drug Eruptions - epidemiology</subject><subject>Drug Eruptions - etiology</subject><subject>Erythema Multiforme - chemically induced</subject><subject>Erythema Multiforme - epidemiology</subject><subject>Exanthema - chemically induced</subject><subject>Exanthema - epidemiology</subject><subject>Female</subject><subject>Gout Suppressants - adverse effects</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmaceutical industry</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Time Factors</subject><subject>Urticaria - chemically induced</subject><subject>Urticaria - epidemiology</subject><subject>Young Adult</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu1DAQhq2qiC5bXqGKhDhmscdxnBw4VKHdFq3gQlWJi-XYY5olTVI7ge3b47DLcq0vtsbfPzP6CEkYXbF4PmxXjOciBeB0BTRWKS8BVrsTsjh-nJIF5VSmecmLM_ImhC2ljDMpXpMzoJIXHGBB1tU06g77KSTa_kIfMLF--pF41GZs-i4kTZfo5KEPQzPqNq11QJtUD02HER36YWr1zJ2TV063Ad8e7iW5u776Vt2km6_r2-pyk5oszyBlBp0QBjHjYLjODGOZZWDBuLoAiaWzos5dhJ2QDEDWNbU241paLdBlfEne7fsOvn-aMIxq20--iyMVE1AKkBLKSBV7yvg-BI9ODb551P5ZMapmg2qrZlFqFqVmg-qvQbWL0YvDgKl-RHsM_lMWgfcHQAejW-d1Z5rwn-NldBzRJfm45343LT6_eAFVXX2aXzGf7vNNGHF3zGv_U-WSS6Huv6xVsVlv7unn7-qa_wH3sZsn</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Huang, H.-Y.</creator><creator>Luo, X.-Q.</creator><creator>Chan, L.-S.</creator><creator>Cao, Z.-H.</creator><creator>Sun, X.-F.</creator><creator>Xu, J.-H.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>201103</creationdate><title>Cutaneous adverse drug reactions in a hospital-based Chinese population</title><author>Huang, H.-Y. ; Luo, X.-Q. ; Chan, L.-S. ; Cao, Z.-H. ; Sun, X.-F. ; Xu, J.-H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4642-1cef55cee432c3a4c114d12d2cfb827e9fd5b6fc46f571227bb0dd43a7da5ef43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Allopurinol - adverse effects</topic><topic>Analgesics</topic><topic>Analgesics - adverse effects</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anticonvulsants - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>China - epidemiology</topic><topic>Dermatology</topic><topic>Drug Eruptions - epidemiology</topic><topic>Drug Eruptions - etiology</topic><topic>Erythema Multiforme - chemically induced</topic><topic>Erythema Multiforme - epidemiology</topic><topic>Exanthema - chemically induced</topic><topic>Exanthema - epidemiology</topic><topic>Female</topic><topic>Gout Suppressants - adverse effects</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Length of Stay - statistics & numerical data</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmaceutical industry</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>Time Factors</topic><topic>Urticaria - chemically induced</topic><topic>Urticaria - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, H.-Y.</creatorcontrib><creatorcontrib>Luo, X.-Q.</creatorcontrib><creatorcontrib>Chan, L.-S.</creatorcontrib><creatorcontrib>Cao, Z.-H.</creatorcontrib><creatorcontrib>Sun, X.-F.</creatorcontrib><creatorcontrib>Xu, J.-H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, H.-Y.</au><au>Luo, X.-Q.</au><au>Chan, L.-S.</au><au>Cao, Z.-H.</au><au>Sun, X.-F.</au><au>Xu, J.-H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutaneous adverse drug reactions in a hospital-based Chinese population</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2011-03</date><risdate>2011</risdate><volume>36</volume><issue>2</issue><spage>135</spage><epage>141</epage><pages>135-141</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><coden>CEDEDE</coden><abstract>Summary
Background. Cutaneous adverse drug reactions (CADRs) are common skin adverse reactions associated with drugs.
Aim. To assess recent trends in CADRs and the drugs associated with them, using data from the past 5 years in the largest single database available on a hospital‐based population in China.
Methods. All clinical records of inpatients admitted with a diagnosis of CADR to the Dermatology Ward, Huashan Hospital from January 2004 to December 2008 were retrospectively studied.
Results. In the 734 patients, the three most common types of CADRs were nonsevere reactions, erythema multiforme (EM)‐like eruptions (n = 255), urticaria (n = 192) and exanthematous reactions (n = 159), followed by three severe reactions: Stevens–Johnson syndrome (n = 58), toxic epidermal necrolysis (n = 29) and exfoliative dermatitis (n = 22). The most common single drug associated with the development of all drug eruptions was allopurinol, followed by amoxicillin, cephalosporins, antiepileptic agents and antipyretic/analgesic agents. However, the most common single drugs associated with severe reactions were antiepileptic agents, followed by allopurinol, antipyretic/analgesic agents and cephalosporins. In contrast to patients with nonsevere reactions, patients with severe reactions were more likely to be male (P < 0.001) and to have a greater mean age of onset (P < 0.001), a longer latency period (P < 0.001) and a longer duration of hospitalization (P < 0.001).
Conclusion. In contrast to previous studies, we found allopurinol to be the most common single drug associated with CADRs followed by antibiotics (amoxicillin and cephalosporins), and antiepileptic, especially carbamazepine. A higher incidence of EM‐like eruptions and urticaria was also seen.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20738322</pmid><doi>10.1111/j.1365-2230.2010.03922.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-6938 |
| ispartof | Clinical and experimental dermatology, 2011-03, Vol.36 (2), p.135-141 |
| issn | 0307-6938 1365-2230 |
| language | eng |
| recordid | cdi_proquest_journals_1529527729 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over Allopurinol - adverse effects Analgesics Analgesics - adverse effects Anti-Bacterial Agents - adverse effects Anticonvulsants - adverse effects Biological and medical sciences Child China - epidemiology Dermatology Drug Eruptions - epidemiology Drug Eruptions - etiology Erythema Multiforme - chemically induced Erythema Multiforme - epidemiology Exanthema - chemically induced Exanthema - epidemiology Female Gout Suppressants - adverse effects Hospitalization Humans Length of Stay - statistics & numerical data Male Medical sciences Middle Aged Pharmaceutical industry Retrospective Studies Sex Factors Time Factors Urticaria - chemically induced Urticaria - epidemiology Young Adult |
| title | Cutaneous adverse drug reactions in a hospital-based Chinese population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T21%3A22%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cutaneous%20adverse%20drug%20reactions%20in%20a%20hospital-based%20Chinese%20population&rft.jtitle=Clinical%20and%20experimental%20dermatology&rft.au=Huang,%20H.-Y.&rft.date=2011-03&rft.volume=36&rft.issue=2&rft.spage=135&rft.epage=141&rft.pages=135-141&rft.issn=0307-6938&rft.eissn=1365-2230&rft.coden=CEDEDE&rft_id=info:doi/10.1111/j.1365-2230.2010.03922.x&rft_dat=%3Cproquest_cross%3E3317437011%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1529527729&rft_id=info:pmid/20738322&rfr_iscdi=true |