ABT-450/r–Ombitasvir and Dasabuvir with or without Ribavirin for HCV

Among previously untreated patients with HCV genotype 1 infection, three new antiviral agents, with or without ribavirin, resulted in high rates of sustained virologic response. Omission of ribavirin resulted in reduced response in genotype 1a infection but not in genotype 1b infection. Hepatitis C...

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Veröffentlicht in:	The New England journal of medicine 2014-05, Vol.370 (21), p.1983-1992
Hauptverfasser:	Ferenci, Peter, Bernstein, David, Lalezari, Jacob, Cohen, Daniel, Luo, Yan, Cooper, Curtis, Tam, Edward, Marinho, Rui T, Tsai, Naoky, Nyberg, Anders, Box, Terry D, Younes, Ziad, Enayati, Pedram, Green, Sinikka, Baruch, Yaacov, Bhandari, Bal Raj, Caruntu, Florin Alexandru, Sepe, Thomas, Chulanov, Vladimir, Janczewska, Ewa, Rizzardini, Giuliano, Gervain, Judit, Planas, Ramon, Moreno, Christophe, Hassanein, Tarek, Xie, Wangang, King, Martin, Podsadecki, Thomas, Reddy, K. Rajender
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anilides - adverse effects Anilides - therapeutic use Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Antiviral drugs Body weight Carbamates - adverse effects Carbamates - therapeutic use Cirrhosis Clinical trials Drug Resistance, Viral Drug therapy Drug Therapy, Combination Fatigue Female Genotype Genotype & phenotype Genotypes Headache Hemoglobin Hemoglobins - analysis Hepacivirus - genetics Hepacivirus - isolation & purification Hepatitis Hepatitis C Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Humans Infections Interferon Macrocyclic Compounds - adverse effects Macrocyclic Compounds - therapeutic use Male Middle Aged Nausea Patients Recurrence Ribavirin Ribavirin - adverse effects Ribavirin - therapeutic use Ribonucleic acid Ritonavir RNA RNA, Viral - blood
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