ROCK1 translocates from non-caveolar to caveolar regions upon KCl stimulation in airway smooth muscle

Airway smooth muscle (ASM) membrane depolarization through KCl opens L-type voltage dependent Ca2+ channels (Ca(v)1.2); its opening was considered the cause of KCl contraction. This substance is used to bypass intracellular second messenger pathways. It is now clear that KCl also activates RhoA/Rho...

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Veröffentlicht in:	Physiological research 2014-01, Vol.63 (2), p.179-187
Hauptverfasser:	Sommer, B, Montano, L M, Chávez, J, Carbajal, V, García-Hernandez, L M, Irles, C, Jiménez-Garduno, A M, Ortega, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Caveolae - drug effects Caveolae - metabolism Cytoskeleton Experiments Kinases Membranes Muscle Contraction - drug effects Muscle Contraction - physiology Muscle Relaxants, Central - pharmacology Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscular system Organ Culture Techniques Potassium Chloride - pharmacology Protein Transport - drug effects Protein Transport - physiology rho-Associated Kinases - metabolism Rodents Smooth muscle Sucrose Trachea - drug effects Trachea - metabolism
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