MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR‐145 and miR‐451 as tumor suppressors

Liposarcomas are rare, heterogeneous and malignant tumors that can be divided into four histological subtypes with different characteristics and clinical behavior. Treatment consists of surgery in combination with systemic chemotherapy, but nevertheless mortality rates are high. More insight into th...

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Veröffentlicht in:	International journal of cancer 2014-07, Vol.135 (2), p.348-361
Hauptverfasser:	Gits, Caroline M.M., Kuijk, Patricia F., Jonkers, Moniek B.E., Boersma, Antonius W.M., Smid, Marcel, Ijcken, Wilfred F., Coindre, Jean‐Michel, Chibon, Fréderic, Verhoef, Cornelis, Mathijssen, Ron H.J., Bakker, Michael A., Verweij, Jaap, Sleijfer, Stefan, Wiemer, Erik A.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Apoptosis Biological and medical sciences Cancer Cell cycle Cluster Analysis Dermatology Female Flow Cytometry Genes, Tumor Suppressor Humans liposarcoma Liposarcoma - genetics Liposarcoma - pathology Male Medical research Medical sciences microRNA MicroRNAs MicroRNAs - genetics Middle Aged miR‐145 miR‐451 Mortality Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction Transcriptome Transfection tumor suppressors Tumors Tumors of the skin and soft tissue. Premalignant lesions
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