Predictability, efficacy and safety of radiosensitization of glioblastoma‐initiating cells by the ATM inhibitor KU‐60019

We have previously shown that pharmacological inhibition of ataxia telangiectasia mutated (ATM) protein sensitizes glioblastoma‐initiating cells (GICs) to ionizing radiation (IR). Herein, we report the experimental conditions to overcome GIC radioresistance in vitro using the specific ATM inhibitor...

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Veröffentlicht in:	International journal of cancer 2014-07, Vol.135 (2), p.479-491
Hauptverfasser:	Vecchio, Donatella, Daga, Antonio, Carra, Elisa, Marubbi, Daniela, Baio, Gabriella, Neumaier, Carlo E., Vagge, Stefano, Corvò, Renzo, Pia Brisigotti, Maria, Louis Ravetti, Jean, Zunino, Annalisa, Poggi, Alessandro, Mascelli, Samantha, Raso, Alessandro, Frosina, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Biological and medical sciences Brain cancer Brain Neoplasms - pathology Cancer Cell Line, Tumor DNA damage response glioblastoma Glioblastoma - pathology Humans Medical research Medical sciences Mice Morpholines - pharmacology Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplastic Stem Cells - drug effects Neurology PI3K Proteins Radiation therapy Radiation Tolerance - drug effects Radiation-Sensitizing Agents - pharmacology radiotherapy resistance Thioxanthenes - pharmacology TP53 Tumors Tumors of the nervous system. Phacomatoses Xenograft Model Antitumor Assays
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