Structural brain changes in early-onset and late-onset depression: An update of volumetric MRI findings
ABSTRACT Early‐onset (EOD) and late‐onset depression (LOD) are associated with different neuropsychological syndromes and structural brain changes. In this article, neuroimaging studies examining structural brain changes in elderly depressed patients are reviewed. The presented findings support curr...
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| Veröffentlicht in: | International journal of imaging systems and technology 2014-06, Vol.24 (2), p.149-160 |
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| container_title | International journal of imaging systems and technology |
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| creator | Tittmann, Mandy Günther, Thomas Sacher, Julia Himmerich, Hubertus Villringer, Arno Hegerl, Ulrich Schönknecht, Peter |
| description | ABSTRACT
Early‐onset (EOD) and late‐onset depression (LOD) are associated with different neuropsychological syndromes and structural brain changes. In this article, neuroimaging studies examining structural brain changes in elderly depressed patients are reviewed. The presented findings support current assumptions that depression in the elderly generally is associated with volume reductions in brain structures, notably in the hippocampus and the orbitofrontal cortex (OFC). Concerning structural cerebral differences between EOD and LOD, the review yielded conflicting results—only for OFC, but not for amygdala or hippocampus, pronounced effects in LOD than in EOD can be assumed. © 2014 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 24, 149–160, 2014 |
| doi_str_mv | 10.1002/ima.22089 |
| format | Article |
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Early‐onset (EOD) and late‐onset depression (LOD) are associated with different neuropsychological syndromes and structural brain changes. In this article, neuroimaging studies examining structural brain changes in elderly depressed patients are reviewed. The presented findings support current assumptions that depression in the elderly generally is associated with volume reductions in brain structures, notably in the hippocampus and the orbitofrontal cortex (OFC). Concerning structural cerebral differences between EOD and LOD, the review yielded conflicting results—only for OFC, but not for amygdala or hippocampus, pronounced effects in LOD than in EOD can be assumed. © 2014 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 24, 149–160, 2014</description><identifier>ISSN: 0899-9457</identifier><identifier>EISSN: 1098-1098</identifier><identifier>DOI: 10.1002/ima.22089</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Adult and adolescent clinical studies ; amygdala ; Biological and medical sciences ; Child clinical studies ; depression in the elderly ; hippocampus ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Mood disorders ; morphometry ; MRI ; Nervous system ; Organic mental disorders. Neuropsychology ; prefrontal cortex ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; volumetry</subject><ispartof>International journal of imaging systems and technology, 2014-06, Vol.24 (2), p.149-160</ispartof><rights>Copyright © 2014 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3659-36720a0d33b30ea329cdb8aba3373b2cbbfd6898c409ce661b0a3e8248baf3203</citedby><cites>FETCH-LOGICAL-c3659-36720a0d33b30ea329cdb8aba3373b2cbbfd6898c409ce661b0a3e8248baf3203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fima.22089$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fima.22089$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27902,27903,45552,45553</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28565834$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Tittmann, Mandy</creatorcontrib><creatorcontrib>Günther, Thomas</creatorcontrib><creatorcontrib>Sacher, Julia</creatorcontrib><creatorcontrib>Himmerich, Hubertus</creatorcontrib><creatorcontrib>Villringer, Arno</creatorcontrib><creatorcontrib>Hegerl, Ulrich</creatorcontrib><creatorcontrib>Schönknecht, Peter</creatorcontrib><title>Structural brain changes in early-onset and late-onset depression: An update of volumetric MRI findings</title><title>International journal of imaging systems and technology</title><addtitle>Int. J. Imaging Syst. Technol</addtitle><description>ABSTRACT
Early‐onset (EOD) and late‐onset depression (LOD) are associated with different neuropsychological syndromes and structural brain changes. In this article, neuroimaging studies examining structural brain changes in elderly depressed patients are reviewed. The presented findings support current assumptions that depression in the elderly generally is associated with volume reductions in brain structures, notably in the hippocampus and the orbitofrontal cortex (OFC). Concerning structural cerebral differences between EOD and LOD, the review yielded conflicting results—only for OFC, but not for amygdala or hippocampus, pronounced effects in LOD than in EOD can be assumed. © 2014 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 24, 149–160, 2014</description><subject>Adult and adolescent clinical studies</subject><subject>amygdala</subject><subject>Biological and medical sciences</subject><subject>Child clinical studies</subject><subject>depression in the elderly</subject><subject>hippocampus</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>morphometry</subject><subject>MRI</subject><subject>Nervous system</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>prefrontal cortex</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>volumetry</subject><issn>0899-9457</issn><issn>1098-1098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kElPwzAUhC0EEmU58A8sIQ4cQr00ic2tqqBUbBJbj9az4xRDcIqdAP33pLRw4_L8xp75LA1CB5ScUEJY373BCWNEyA3Uo0SKZDk2Ua-7kYkcpPk22onxhRBKU5L20Oy-Ca1p2gAV1gGcx-YZ_MxG3K0WQrVIah9tg8EXuILGrmVh58HG6Gp_iocet_Oie8N1iT_qqn2zTXAGX99NcOl84fws7qGtEqpo99fnLno8P3sYXSRXt-PJaHiVGJ6lMuFZzgiQgnPNiQXOpCm0AA2c51wzo3VZZEIKMyDS2CyjmgC3gg2EhpIzwnfR4Yo7D_V7a2OjXuo2-O5LRVNGck5lPuhcxyuXCXWMwZZqHrrmwkJRopY9qk6pnx4779GaCNFAVQbwxsW_ABNplgq-ZPZXvk9X2cX_QDW5Hv6Sk1XCxcZ-_SUgvKos53mqpjdjNR0_jSnLL9WIfwN2hJCg</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Tittmann, Mandy</creator><creator>Günther, Thomas</creator><creator>Sacher, Julia</creator><creator>Himmerich, Hubertus</creator><creator>Villringer, Arno</creator><creator>Hegerl, Ulrich</creator><creator>Schönknecht, Peter</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201406</creationdate><title>Structural brain changes in early-onset and late-onset depression: An update of volumetric MRI findings</title><author>Tittmann, Mandy ; Günther, Thomas ; Sacher, Julia ; Himmerich, Hubertus ; Villringer, Arno ; Hegerl, Ulrich ; Schönknecht, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3659-36720a0d33b30ea329cdb8aba3373b2cbbfd6898c409ce661b0a3e8248baf3203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult and adolescent clinical studies</topic><topic>amygdala</topic><topic>Biological and medical sciences</topic><topic>Child clinical studies</topic><topic>depression in the elderly</topic><topic>hippocampus</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>morphometry</topic><topic>MRI</topic><topic>Nervous system</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>prefrontal cortex</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>volumetry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tittmann, Mandy</creatorcontrib><creatorcontrib>Günther, Thomas</creatorcontrib><creatorcontrib>Sacher, Julia</creatorcontrib><creatorcontrib>Himmerich, Hubertus</creatorcontrib><creatorcontrib>Villringer, Arno</creatorcontrib><creatorcontrib>Hegerl, Ulrich</creatorcontrib><creatorcontrib>Schönknecht, Peter</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>International journal of imaging systems and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tittmann, Mandy</au><au>Günther, Thomas</au><au>Sacher, Julia</au><au>Himmerich, Hubertus</au><au>Villringer, Arno</au><au>Hegerl, Ulrich</au><au>Schönknecht, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural brain changes in early-onset and late-onset depression: An update of volumetric MRI findings</atitle><jtitle>International journal of imaging systems and technology</jtitle><addtitle>Int. 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Early‐onset (EOD) and late‐onset depression (LOD) are associated with different neuropsychological syndromes and structural brain changes. In this article, neuroimaging studies examining structural brain changes in elderly depressed patients are reviewed. The presented findings support current assumptions that depression in the elderly generally is associated with volume reductions in brain structures, notably in the hippocampus and the orbitofrontal cortex (OFC). Concerning structural cerebral differences between EOD and LOD, the review yielded conflicting results—only for OFC, but not for amygdala or hippocampus, pronounced effects in LOD than in EOD can be assumed. © 2014 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 24, 149–160, 2014</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1002/ima.22089</doi><tpages>12</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies amygdala Biological and medical sciences Child clinical studies depression in the elderly hippocampus Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mood disorders morphometry MRI Nervous system Organic mental disorders. Neuropsychology prefrontal cortex Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiodiagnosis. Nmr imagery. Nmr spectrometry volumetry |
| title | Structural brain changes in early-onset and late-onset depression: An update of volumetric MRI findings |
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