HMGCR is necessary for the tumorigenecity of esophageal squamous cell carcinoma and is regulated by Myc

Hydroxymethylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme of mevalonate pathway, has been involved in the tumorigenesis of several tumor types. Our previous study has showed that statin, the inhibitor of HMGCR, inhibited the tumorigenecity of esophageal squamous cell carcinoma (ES...

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Veröffentlicht in:	Tumor biology 2014-05, Vol.35 (5), p.4123-4129
Hauptverfasser:	Zhong, Chenxi, Fan, Limin, Yao, Feng, Shi, Jianxin, Fang, Wentao, Zhao, Heng
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - etiology Cell Line, Tumor Cell Movement Cell Proliferation Cells Esophageal cancer Esophageal Neoplasms - etiology Esophageal Squamous Cell Carcinoma Extracellular Signal-Regulated MAP Kinases - physiology Gene expression Genes, myc - physiology Humans Hydroxymethylglutaryl CoA Reductases - physiology Mevalonic Acid - metabolism Research Article Tumors
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