Universal modular system for in vitro screening of potential inhibitors of HIV-1 replication
A system based on recombinant lentiviral vectors has been designed for safe screening of potential anti-HIV drugs. The system can be used to evaluate the sensitivity of HIV-1 reverse transcriptase and integrase (wild-type as well as mutant forms of these enzymes detected in drug-resistant virus isol...
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| Veröffentlicht in: | Molecular biology (New York) 2014-03, Vol.48 (2), p.297-300 |
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| container_title | Molecular biology (New York) |
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| creator | Prokofjeva, M. M. Orlova, N. N. Gornostaeva, A. S. Shulgin, A. A. Nikitenko, N. A. Senchenko, V. N. Lebedev, T. D. Spirin, P. V. Riecken, K. Fehse, B. Stocking, C. Prassolov, V. S. |
| description | A system based on recombinant lentiviral vectors has been designed for safe screening of potential anti-HIV drugs. The system can be used to evaluate the sensitivity of HIV-1 reverse transcriptase and integrase (wild-type as well as mutant forms of these enzymes detected in drug-resistant virus isolates) to different drugs and substances, as well as to screen inhibitors of other stages of the HIV-1 life cycle. |
| doi_str_mv | 10.1134/S0026893314020150 |
| format | Article |
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M. ; Orlova, N. N. ; Gornostaeva, A. S. ; Shulgin, A. A. ; Nikitenko, N. A. ; Senchenko, V. N. ; Lebedev, T. D. ; Spirin, P. V. ; Riecken, K. ; Fehse, B. ; Stocking, C. ; Prassolov, V. S.</creator><creatorcontrib>Prokofjeva, M. M. ; Orlova, N. N. ; Gornostaeva, A. S. ; Shulgin, A. A. ; Nikitenko, N. A. ; Senchenko, V. N. ; Lebedev, T. D. ; Spirin, P. V. ; Riecken, K. ; Fehse, B. ; Stocking, C. ; Prassolov, V. S.</creatorcontrib><description>A system based on recombinant lentiviral vectors has been designed for safe screening of potential anti-HIV drugs. The system can be used to evaluate the sensitivity of HIV-1 reverse transcriptase and integrase (wild-type as well as mutant forms of these enzymes detected in drug-resistant virus isolates) to different drugs and substances, as well as to screen inhibitors of other stages of the HIV-1 life cycle.</description><identifier>ISSN: 0026-8933</identifier><identifier>EISSN: 1608-3245</identifier><identifier>DOI: 10.1134/S0026893314020150</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Enzymes ; HIV ; Human Genetics ; Human immunodeficiency virus ; Inhibitor drugs ; Life Sciences ; Pharmacology ; Short Communications</subject><ispartof>Molecular biology (New York), 2014-03, Vol.48 (2), p.297-300</ispartof><rights>Pleiades Publishing, Inc. 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-b2845c9a995bcae3d935251bf6e3992aead2747e66f715fe71972ac582c0d8793</citedby><cites>FETCH-LOGICAL-c316t-b2845c9a995bcae3d935251bf6e3992aead2747e66f715fe71972ac582c0d8793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0026893314020150$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0026893314020150$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Prokofjeva, M. 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| subjects | Biochemistry Biomedical and Life Sciences Enzymes HIV Human Genetics Human immunodeficiency virus Inhibitor drugs Life Sciences Pharmacology Short Communications |
| title | Universal modular system for in vitro screening of potential inhibitors of HIV-1 replication |
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