The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human V[gamma]9V[delta]2 T Cells

In humans, Vγ9Vδ2 T cells detect tumor cells and microbial infections, includingMycobacterium tuberculosis, through recognition of small pyrophosphate containing organic molecules known as phosphoantigens (pAgs). Key to pAg-mediated activation of Vγ9Vδ2 T cells is the butyrophilin 3A1 (BTN3A1) prote...

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Veröffentlicht in:	Immunity 2014-05, Vol.40 (4), p.490
Hauptverfasser:	Sandstrom, Andrew, Peigné, Cassie-Marie, Léger, Alexandra, Crooks, James E, Konczak, Fabienne, Gesnel, Marie-Claude, Breathnach, Richard, Bonneville, Marc, Scotet, Emmanuel, Adams, Erin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Experiments Ligands Lymphocytes Mutagenesis Proteins T cell receptors
Online-Zugang:	Volltext
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