Exploring the Interface of Graphene and Biology
To take advantage of the properties of graphene in biomedical applications, well-defined materials need to be matched with intended applications. Graphene is highly conductive, flexible, and has controllable permittivity and hydrophilicity, among its other distinctive properties ( 1 , 2 ). These pro...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2014-04, Vol.344 (6181), p.261-263 |
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| creator | Kostarelos, Kostas Novoselov, Kostya S. |
| description | To take advantage of the properties of graphene in biomedical applications, well-defined materials need to be matched with intended applications.
Graphene is highly conductive, flexible, and has controllable permittivity and hydrophilicity, among its other distinctive properties (
1
,
2
). These properties could enable the development of multifunctional biomedical devices (
3
). A key issue for such applications is the determination of the possible interactions with components of the biological milieu to reveal the opportunities offered and the limitations posed. As with any other nanomaterial, biological studies of graphene should be performed with very specific, well-designed, and well-characterized types of materials with defined exposure. We outline three layers of complexity that are interconnected and need to be considered carefully in the development of graphene for use in biomedical applications: material characteristics; interactions with biological components (tissues, cells, and proteins); and biological activity outcomes. |
| doi_str_mv | 10.1126/science.1246736 |
| format | Article |
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Graphene is highly conductive, flexible, and has controllable permittivity and hydrophilicity, among its other distinctive properties (
1
,
2
). These properties could enable the development of multifunctional biomedical devices (
3
). A key issue for such applications is the determination of the possible interactions with components of the biological milieu to reveal the opportunities offered and the limitations posed. As with any other nanomaterial, biological studies of graphene should be performed with very specific, well-designed, and well-characterized types of materials with defined exposure. We outline three layers of complexity that are interconnected and need to be considered carefully in the development of graphene for use in biomedical applications: material characteristics; interactions with biological components (tissues, cells, and proteins); and biological activity outcomes.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1246736</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington: American Association for the Advancement of Science</publisher><subject>Astronomical extinction ; Biodegradation ; Biology ; Biomedical research ; Carbon ; Cell membranes ; Endocytosis ; Extinct species ; Graphene ; Materials ; PERSPECTIVES ; Plasma interactions ; Specimens ; Voucher specimens</subject><ispartof>Science (American Association for the Advancement of Science), 2014-04, Vol.344 (6181), p.261-263</ispartof><rights>Copyright © 2014 American Association for the Advancement of Science</rights><rights>Copyright © 2014, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-7647cc40a7f5e658d3209429a78566764314f3c1e28b284fdedb9b92b93a0ed93</citedby><cites>FETCH-LOGICAL-c357t-7647cc40a7f5e658d3209429a78566764314f3c1e28b284fdedb9b92b93a0ed93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24743674$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24743674$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2882,2883,27923,27924,58016,58249</link.rule.ids></links><search><creatorcontrib>Kostarelos, Kostas</creatorcontrib><creatorcontrib>Novoselov, Kostya S.</creatorcontrib><title>Exploring the Interface of Graphene and Biology</title><title>Science (American Association for the Advancement of Science)</title><description>To take advantage of the properties of graphene in biomedical applications, well-defined materials need to be matched with intended applications.
Graphene is highly conductive, flexible, and has controllable permittivity and hydrophilicity, among its other distinctive properties (
1
,
2
). These properties could enable the development of multifunctional biomedical devices (
3
). A key issue for such applications is the determination of the possible interactions with components of the biological milieu to reveal the opportunities offered and the limitations posed. As with any other nanomaterial, biological studies of graphene should be performed with very specific, well-designed, and well-characterized types of materials with defined exposure. We outline three layers of complexity that are interconnected and need to be considered carefully in the development of graphene for use in biomedical applications: material characteristics; interactions with biological components (tissues, cells, and proteins); and biological activity outcomes.</description><subject>Astronomical extinction</subject><subject>Biodegradation</subject><subject>Biology</subject><subject>Biomedical research</subject><subject>Carbon</subject><subject>Cell membranes</subject><subject>Endocytosis</subject><subject>Extinct species</subject><subject>Graphene</subject><subject>Materials</subject><subject>PERSPECTIVES</subject><subject>Plasma interactions</subject><subject>Specimens</subject><subject>Voucher specimens</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNo9kE1LAzEQhoMoWKtnT8KC520n35ujFq2Fghc9h2x20m6pmzXZgv33rrR4GObwPu8MPITcU5hRytQ8-xY7jzPKhNJcXZAJBSNLw4BfkgkAV2UFWl6Tm5x3AGNm-ITMX376fUxttymGLRarbsAUnMcihmKZXL_FDgvXNcVzG_dxc7wlV8HtM96d95R8vr58LN7K9ftytXhal55LPZRaCe29AKeDRCWrhjMwghmnK6nUmHIqAvcUWVWzSoQGm9rUhtWGO8DG8Cl5PN3tU_w-YB7sLh5SN760VFItBGiqRmp-onyKOScMtk_tl0tHS8H-WbFnK_ZsZWw8nBq7PMT0jzOhBVfj_AIMaF5G</recordid><startdate>20140418</startdate><enddate>20140418</enddate><creator>Kostarelos, Kostas</creator><creator>Novoselov, Kostya S.</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20140418</creationdate><title>Exploring the Interface of Graphene and Biology</title><author>Kostarelos, Kostas ; Novoselov, Kostya S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-7647cc40a7f5e658d3209429a78566764314f3c1e28b284fdedb9b92b93a0ed93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Astronomical extinction</topic><topic>Biodegradation</topic><topic>Biology</topic><topic>Biomedical research</topic><topic>Carbon</topic><topic>Cell membranes</topic><topic>Endocytosis</topic><topic>Extinct species</topic><topic>Graphene</topic><topic>Materials</topic><topic>PERSPECTIVES</topic><topic>Plasma interactions</topic><topic>Specimens</topic><topic>Voucher specimens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kostarelos, Kostas</creatorcontrib><creatorcontrib>Novoselov, Kostya S.</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kostarelos, Kostas</au><au>Novoselov, Kostya S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploring the Interface of Graphene and Biology</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><date>2014-04-18</date><risdate>2014</risdate><volume>344</volume><issue>6181</issue><spage>261</spage><epage>263</epage><pages>261-263</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>To take advantage of the properties of graphene in biomedical applications, well-defined materials need to be matched with intended applications.
Graphene is highly conductive, flexible, and has controllable permittivity and hydrophilicity, among its other distinctive properties (
1
,
2
). These properties could enable the development of multifunctional biomedical devices (
3
). A key issue for such applications is the determination of the possible interactions with components of the biological milieu to reveal the opportunities offered and the limitations posed. As with any other nanomaterial, biological studies of graphene should be performed with very specific, well-designed, and well-characterized types of materials with defined exposure. We outline three layers of complexity that are interconnected and need to be considered carefully in the development of graphene for use in biomedical applications: material characteristics; interactions with biological components (tissues, cells, and proteins); and biological activity outcomes.</abstract><cop>Washington</cop><pub>American Association for the Advancement of Science</pub><doi>10.1126/science.1246736</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Science (American Association for the Advancement of Science), 2014-04, Vol.344 (6181), p.261-263 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Astronomical extinction Biodegradation Biology Biomedical research Carbon Cell membranes Endocytosis Extinct species Graphene Materials PERSPECTIVES Plasma interactions Specimens Voucher specimens |
| title | Exploring the Interface of Graphene and Biology |
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