Ankylosing spondylitis macrophage production of higher levels of interleukin‐23 in response to lipopolysaccharide without induction of a significant unfolded protein response

Objective Previous studies of the HLA–B27–transgenic rat model of ankylosing spondylitis (AS) suggested that macrophages develop an intracellular stress response called the unfolded protein response (UPR) and, as a result, secrete increased amounts of cytokines in response to Toll‐like receptor agon...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2011-12, Vol.63 (12), p.3807-3817
Hauptverfasser:	Zeng, Ling, Lindstrom, Mary J., Smith, Judith A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Case-Control Studies CCAAT-Enhancer-Binding Proteins - metabolism Cells, Cultured Chemokines - metabolism Cytokines Cytokines - metabolism Diseases of the osteoarticular system Diseases of the spine Female HLA-B Antigens - metabolism Humans Immune system Inflammatory joint diseases Interferon-gamma - pharmacology Interleukin-23 - metabolism Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Male Medical sciences Middle Aged Oligopeptides - metabolism Patients Proteins Rodents Spondylitis, Ankylosing - metabolism Spondylitis, Ankylosing - pathology Transcription Factor CHOP - metabolism Unfolded Protein Response - drug effects Unfolded Protein Response - physiology Young Adult
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