Sialyl Lewisx: A "Pre-Organized Water Oligomer"?

Organized and released: Sialyl Lewisx (sLex) represents a “pre‐organized water oligomer”, that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLex binding to E‐selectin is shown to be the high degree of pre‐organization allowing an array of directed hydrogen bo...

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Veröffentlicht in:	Angewandte Chemie International Edition 2012-07, Vol.51 (29), p.7327-7331
Hauptverfasser:	Binder, Florian P. C., Lemme, Katrin, Preston, Roland C., Ernst, Beat
Format:	Artikel
Sprache:	eng
Schlagworte:	carbohydrates E-selectin glycomimetics isothermal titration calorimetry sialyl Lewisx
Online-Zugang:	Volltext
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