Sialyl Lewisx: A "Pre-Organized Water Oligomer"?

Sialyl Lewisx: A "Pre-Organized Water Oligomer"?

Organized and released: Sialyl Lewisx (sLex) represents a “pre‐organized water oligomer”, that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLex binding to E‐selectin is shown to be the high degree of pre‐organization allowing an array of directed hydrogen bo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2012-07, Vol.51 (29), p.7327-7331
Hauptverfasser: Binder, Florian P. C., Lemme, Katrin, Preston, Roland C., Ernst, Beat
Format: Artikel
Sprache:eng
Schlagworte:
carbohydrates
E-selectin
glycomimetics
isothermal titration calorimetry
sialyl Lewisx
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 7331
container_issue 29
container_start_page 7327
container_title Angewandte Chemie International Edition
container_volume 51
creator Binder, Florian P. C.
Lemme, Katrin
Preston, Roland C.
Ernst, Beat
description Organized and released: Sialyl Lewisx (sLex) represents a “pre‐organized water oligomer”, that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLex binding to E‐selectin is shown to be the high degree of pre‐organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture).
doi_str_mv 10.1002/anie.201202555
format Article
fullrecord <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_proquest_journals_1516687041</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3277264181</sourcerecordid><originalsourceid>FETCH-LOGICAL-i2015-35c4fac13ad3529fbadf5715f86d676aca2f1f3066c292ed4f6c782b6d82721e3</originalsourceid><addsrcrecordid>eNo9kEtPAjEUhRujiYhuXU9wXextp49xY4AgEhGMj7BsykxLisPDDgTw11uCYXXvTb5z7slB6BZIEwih92bhbZMSoIRyzs9QDTgFzKRk53FPGcNScbhEV1U1i7xSRNQQ-fCm3JfJwG59tXtIWknjLVg8CtNo92uLZGzWNiSj0k-Xcxsaj9fowpmysjf_s46-nrqfnWc8GPX6ndYA-xiBY8bz1JkcmCkYp5mbmMJxCdwpUQgpTG6oA8eIEDnNqC1SJ3Kp6EQUikoKltXR3dF3FZY_G1ut9Wy5CYv4UgMHIZQkKUQqO1JbX9q9XgU_N2GvgehDJfpQiT5VolvDfvd0RS0-an21truT1oRvLSSTXI-HPf3e7sALvGa6zf4AXCxj6w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1516687041</pqid></control><display><type>article</type><title>Sialyl Lewisx: A "Pre-Organized Water Oligomer"?</title><source>Wiley Journals</source><creator>Binder, Florian P. C. ; Lemme, Katrin ; Preston, Roland C. ; Ernst, Beat</creator><creatorcontrib>Binder, Florian P. C. ; Lemme, Katrin ; Preston, Roland C. ; Ernst, Beat</creatorcontrib><description>Organized and released: Sialyl Lewisx (sLex) represents a “pre‐organized water oligomer”, that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLex binding to E‐selectin is shown to be the high degree of pre‐organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture).</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201202555</identifier><identifier>CODEN: ACIEAY</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>carbohydrates ; E-selectin ; glycomimetics ; isothermal titration calorimetry ; sialyl Lewisx</subject><ispartof>Angewandte Chemie International Edition, 2012-07, Vol.51 (29), p.7327-7331</ispartof><rights>Copyright © 2012 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim</rights><rights>Copyright © 2012 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201202555$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201202555$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Binder, Florian P. C.</creatorcontrib><creatorcontrib>Lemme, Katrin</creatorcontrib><creatorcontrib>Preston, Roland C.</creatorcontrib><creatorcontrib>Ernst, Beat</creatorcontrib><title>Sialyl Lewisx: A "Pre-Organized Water Oligomer"?</title><title>Angewandte Chemie International Edition</title><addtitle>Angew. Chem. Int. Ed</addtitle><description>Organized and released: Sialyl Lewisx (sLex) represents a “pre‐organized water oligomer”, that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLex binding to E‐selectin is shown to be the high degree of pre‐organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture).</description><subject>carbohydrates</subject><subject>E-selectin</subject><subject>glycomimetics</subject><subject>isothermal titration calorimetry</subject><subject>sialyl Lewisx</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNo9kEtPAjEUhRujiYhuXU9wXextp49xY4AgEhGMj7BsykxLisPDDgTw11uCYXXvTb5z7slB6BZIEwih92bhbZMSoIRyzs9QDTgFzKRk53FPGcNScbhEV1U1i7xSRNQQ-fCm3JfJwG59tXtIWknjLVg8CtNo92uLZGzWNiSj0k-Xcxsaj9fowpmysjf_s46-nrqfnWc8GPX6ndYA-xiBY8bz1JkcmCkYp5mbmMJxCdwpUQgpTG6oA8eIEDnNqC1SJ3Kp6EQUikoKltXR3dF3FZY_G1ut9Wy5CYv4UgMHIZQkKUQqO1JbX9q9XgU_N2GvgehDJfpQiT5VolvDfvd0RS0-an21truT1oRvLSSTXI-HPf3e7sALvGa6zf4AXCxj6w</recordid><startdate>20120716</startdate><enddate>20120716</enddate><creator>Binder, Florian P. C.</creator><creator>Lemme, Katrin</creator><creator>Preston, Roland C.</creator><creator>Ernst, Beat</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>7TM</scope><scope>K9.</scope></search><sort><creationdate>20120716</creationdate><title>Sialyl Lewisx: A "Pre-Organized Water Oligomer"?</title><author>Binder, Florian P. C. ; Lemme, Katrin ; Preston, Roland C. ; Ernst, Beat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2015-35c4fac13ad3529fbadf5715f86d676aca2f1f3066c292ed4f6c782b6d82721e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>carbohydrates</topic><topic>E-selectin</topic><topic>glycomimetics</topic><topic>isothermal titration calorimetry</topic><topic>sialyl Lewisx</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Binder, Florian P. C.</creatorcontrib><creatorcontrib>Lemme, Katrin</creatorcontrib><creatorcontrib>Preston, Roland C.</creatorcontrib><creatorcontrib>Ernst, Beat</creatorcontrib><collection>Istex</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Binder, Florian P. C.</au><au>Lemme, Katrin</au><au>Preston, Roland C.</au><au>Ernst, Beat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sialyl Lewisx: A "Pre-Organized Water Oligomer"?</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew. Chem. Int. Ed</addtitle><date>2012-07-16</date><risdate>2012</risdate><volume>51</volume><issue>29</issue><spage>7327</spage><epage>7331</epage><pages>7327-7331</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><coden>ACIEAY</coden><abstract>Organized and released: Sialyl Lewisx (sLex) represents a “pre‐organized water oligomer”, that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLex binding to E‐selectin is shown to be the high degree of pre‐organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture).</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/anie.201202555</doi><tpages>5</tpages><edition>International ed. in English</edition></addata></record>
fulltext fulltext
identifier ISSN: 1433-7851
ispartof Angewandte Chemie International Edition, 2012-07, Vol.51 (29), p.7327-7331
issn 1433-7851
1521-3773
language eng
recordid cdi_proquest_journals_1516687041
source Wiley Journals
subjects carbohydrates
E-selectin
glycomimetics
isothermal titration calorimetry
sialyl Lewisx
title Sialyl Lewisx: A "Pre-Organized Water Oligomer"?
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T04%3A25%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_wiley&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sialyl%20Lewisx:%20A%20%22Pre-Organized%20Water%20Oligomer%22?&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.au=Binder,%20Florian%20P.%20C.&rft.date=2012-07-16&rft.volume=51&rft.issue=29&rft.spage=7327&rft.epage=7331&rft.pages=7327-7331&rft.issn=1433-7851&rft.eissn=1521-3773&rft.coden=ACIEAY&rft_id=info:doi/10.1002/anie.201202555&rft_dat=%3Cproquest_wiley%3E3277264181%3C/proquest_wiley%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1516687041&rft_id=info:pmid/&rfr_iscdi=true