Mechanism of Tc toxin action revealed in molecular detail

Tripartite Tc toxin complexes of bacterial pathogens perforate the host membrane and translocate toxic enzymes into the host cell, including in humans. The underlying mechanism is complex but poorly understood. Here we report the first, to our knowledge, high-resolution structures of a TcA subunit i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2014-04, Vol.508 (7494), p.61-65
Hauptverfasser:	Meusch, Dominic, Gatsogiannis, Christos, Efremov, Rouslan G., Lang, Alexander E., Hofnagel, Oliver, Vetter, Ingrid R., Aktories, Klaus, Raunser, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/535/1258/1259 631/535/1266 82 ADP Ribose Transferases - metabolism Analysis Bacteria Bacterial proteins Bacterial Toxins - chemistry Bacterial Toxins - metabolism Binding Sites Cell Membrane - metabolism Crystal structure Crystallography, X-Ray Cytotoxicity Host Specificity Humanities and Social Sciences Hydrogen-Ion Concentration Models, Molecular Molecular weight multidisciplinary Neuraminidase - chemistry Photorhabdus - chemistry Porosity Protein Structure, Tertiary Protein Subunits - chemistry Protein Subunits - metabolism Protein Transport Protein Unfolding Proteins Science Structure Structure-Activity Relationship Toxins Translocation Virulence (Microbiology)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!