Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells

Purpose Temsirolimus (TEM) is a novel, water-soluble mammalian target of rapamycin (mTOR) inhibitor that has shown activity against a wide range of cancers in preclinical models, but its efficacy against colorectal cancer (CRC) has not been fully explored. Methods We evaluated the antitumor effect o...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2014-05, Vol.140 (5), p.769-781
Hauptverfasser:	Kaneko, Manabu, Nozawa, Hiroaki, Hiyoshi, Masaya, Tada, Noriko, Murono, Koji, Nirei, Takako, Emoto, Shigenobu, Kishikawa, Junko, Iida, Yuuki, Sunami, Eiji, Tsuno, Nelson H., Kitayama, Joji, Takahashi, Koki, Watanabe, Toshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - administration & dosage Apoptosis - drug effects Cancer Research Cell Line, Tumor Cellular biology Chloroquine - administration & dosage Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Cyclin D1 - biosynthesis Gene Expression Regulation, Neoplastic - drug effects Hematology HT29 Cells Humans Inhibitor drugs Internal Medicine Medicine Medicine & Public Health Mice Oncology Original Article – Cancer Research Sirolimus - administration & dosage Sirolimus - analogs & derivatives TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - biosynthesis Xenograft Model Antitumor Assays
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