One-pot two-step synthesis of 2,5-dihydro-2-oxofuran-3-carboxamides

One-pot two-step synthesis of 2,5-dihydro-2-oxofuran-3-carboxamides

2,5-Dihydro-2-oxofuran-3-carboxamides were synthesized by a one-pot two-step reaction catalyzed by sodium methoxide. Readily available tertiary α-hydroxyketones were condensed with substituted cyanoacetamides to give 2-imino-2,5-dihydrofuran-3-carboxamides that, without isolation, were hydrolized to...

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Veröffentlicht in:Heterocyclic communications 2014-04, Vol.20 (2), p.77-79
Hauptverfasser: Tokmajyan, Gayane, Karapetyan, Lusine
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container_title Heterocyclic communications
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creator Tokmajyan, Gayane
Karapetyan, Lusine
description 2,5-Dihydro-2-oxofuran-3-carboxamides were synthesized by a one-pot two-step reaction catalyzed by sodium methoxide. Readily available tertiary α-hydroxyketones were condensed with substituted cyanoacetamides to give 2-imino-2,5-dihydrofuran-3-carboxamides that, without isolation, were hydrolized to the title products.
doi_str_mv 10.1515/hc-2014-0023
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title One-pot two-step synthesis of 2,5-dihydro-2-oxofuran-3-carboxamides
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