Drugging the p53 pathway: understanding the route to clinical efficacy
The tumour suppressor p53 is the most frequently mutated gene in human cancer, with more than half of all human tumours carrying mutations in this particular gene. Intense efforts to develop drugs that could activate or restore the p53 pathway have now reached clinical trials. The first clinical res...
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| Veröffentlicht in: | Nature reviews. Drug discovery 2014-04, Vol.13 (4), p.256 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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