Safety, bioavailability and mechanism of action of nitric oxide to control Bovine Respiratory Disease Complex in calves entering a feedlot
Bovine Respiratory Disease Complex (BRDc), a multi-factorial disease, negatively impacts the cattle industry. Nitric oxide (NO), a naturally occurring molecule, may have utility controlling incidence of BRDc. Safety, bioavailability, toxicology and tolerance/stress of administering NO to cattle is e...
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| Veröffentlicht in: | Research in veterinary science 2014-04, Vol.96 (2), p.328-337 |
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| creator | Regev-Shoshani, G. Vimalanathan, S. Prema, D. Church, J.S. Reudink, M.W. Nation, N. Miller, C.C. |
| description | Bovine Respiratory Disease Complex (BRDc), a multi-factorial disease, negatively impacts the cattle industry. Nitric oxide (NO), a naturally occurring molecule, may have utility controlling incidence of BRDc. Safety, bioavailability, toxicology and tolerance/stress of administering NO to cattle is evaluated herein. Thirteen, crossbred, multiple-sourced, commingled commercial weaned beef calves were treated multiple times intranasally over a 4week period with either a nitric oxide releasing solution (treatment) or saline (control). Exhaled NO, methemoglobin percent (MetHg) and serum nitrites demonstrated biological availability as a result of treatment. Cortisol levels, tissue nitrites, behavior and gross and macroscopic pathology of organs were all normal. Moreover, preliminary in vitro studies using Mannheimia haemolytica, Infectious Bovine Rhinotracheitis, Bovine Parainfluenza-3 and Bovine Respiratory Syncytial Virus, suggest a potential explanation for the previously demonstrated efficacy for BRDc. These data confirm the bioavailability, safety and lack of residual of NO treatment to cattle, along with the bactericidal and virucidal effects. |
| doi_str_mv | 10.1016/j.rvsc.2013.12.012 |
| format | Article |
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Nitric oxide (NO), a naturally occurring molecule, may have utility controlling incidence of BRDc. Safety, bioavailability, toxicology and tolerance/stress of administering NO to cattle is evaluated herein. Thirteen, crossbred, multiple-sourced, commingled commercial weaned beef calves were treated multiple times intranasally over a 4week period with either a nitric oxide releasing solution (treatment) or saline (control). Exhaled NO, methemoglobin percent (MetHg) and serum nitrites demonstrated biological availability as a result of treatment. Cortisol levels, tissue nitrites, behavior and gross and macroscopic pathology of organs were all normal. Moreover, preliminary in vitro studies using Mannheimia haemolytica, Infectious Bovine Rhinotracheitis, Bovine Parainfluenza-3 and Bovine Respiratory Syncytial Virus, suggest a potential explanation for the previously demonstrated efficacy for BRDc. 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Nitric oxide (NO), a naturally occurring molecule, may have utility controlling incidence of BRDc. Safety, bioavailability, toxicology and tolerance/stress of administering NO to cattle is evaluated herein. Thirteen, crossbred, multiple-sourced, commingled commercial weaned beef calves were treated multiple times intranasally over a 4week period with either a nitric oxide releasing solution (treatment) or saline (control). Exhaled NO, methemoglobin percent (MetHg) and serum nitrites demonstrated biological availability as a result of treatment. Cortisol levels, tissue nitrites, behavior and gross and macroscopic pathology of organs were all normal. Moreover, preliminary in vitro studies using Mannheimia haemolytica, Infectious Bovine Rhinotracheitis, Bovine Parainfluenza-3 and Bovine Respiratory Syncytial Virus, suggest a potential explanation for the previously demonstrated efficacy for BRDc. These data confirm the bioavailability, safety and lack of residual of NO treatment to cattle, along with the bactericidal and virucidal effects.</description><subject>Administration, Intranasal</subject><subject>Animals</subject><subject>Antibiotics</subject><subject>Antimicrobial</subject><subject>Bacterial infections</subject><subject>Behavior, Animal - drug effects</subject><subject>Bovine Respiratory Disease</subject><subject>Bovine Respiratory Disease Complex - drug therapy</subject><subject>Bovine Respiratory Disease Complex - microbiology</subject><subject>Bovine Respiratory Disease Complex - virology</subject><subject>Cattle</subject><subject>Cytotoxicity</subject><subject>Disease</subject><subject>Drug dosages</subject><subject>Free radicals</subject><subject>Herpes viruses</subject><subject>Histocytochemistry - veterinary</subject><subject>Hydrocortisone - blood</subject><subject>Infections</subject><subject>Lung - microbiology</subject><subject>Lung - virology</subject><subject>Mammals</subject><subject>Methemoglobin - analysis</subject><subject>Mortality</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - administration & dosage</subject><subject>Nitric Oxide - pharmacology</subject><subject>Nitric Oxide - therapeutic use</subject><subject>Nitrites - blood</subject><subject>Nitrogen dioxide</subject><subject>Proteins</subject><subject>Shipping fever</subject><subject>Sustainability</subject><subject>Undifferentiated fever</subject><subject>Veterinary medicine</subject><subject>Viral infections</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMuOEzEQRS0EYsLAD7BAltjSjct2Ox2JDYSnNBISj7Xl2NVQUccOttOa_AJfTbcysGRVtTj3luow9hRECwLMy32bp-JbKUC1IFsB8h5bQadkI42B-2wlhNJNJ_v-ij0qZS-E0ADrh-xKaq206MyK_f7qBqznF3xHyU2ORrejkeqZuxj4Af1PF6kceBq485VSXLZINZPn6ZYC8pq4T7HmNPI3aaKI_AuWI2VXUz7zt1TQFeTbdDiOeMspcu_GCQvHWDFT_MEdHxDDmOpj9mBwY8End_OafX__7tv2Y3Pz-cOn7eubxqte18Z1UksPsu9gEMbotd-hHJQ3_Wbdhd6YAM6p4F0wgMMm9EGZsAZQIN1Ga6mu2fNL7zGnXycs1e7TKcf5pIVOzMimMwslL5TPqZSMgz1mOrh8tiDsot_u7aLfLvotSDvrn0PP7qpPuwOGf5G_vmfg1QXA-cGJMNviCaPHQBl9tSHR__r_AHtJl-g</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Regev-Shoshani, G.</creator><creator>Vimalanathan, S.</creator><creator>Prema, D.</creator><creator>Church, J.S.</creator><creator>Reudink, M.W.</creator><creator>Nation, N.</creator><creator>Miller, C.C.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20140401</creationdate><title>Safety, bioavailability and mechanism of action of nitric oxide to control Bovine Respiratory Disease Complex in calves entering a feedlot</title><author>Regev-Shoshani, G. ; 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Nitric oxide (NO), a naturally occurring molecule, may have utility controlling incidence of BRDc. Safety, bioavailability, toxicology and tolerance/stress of administering NO to cattle is evaluated herein. Thirteen, crossbred, multiple-sourced, commingled commercial weaned beef calves were treated multiple times intranasally over a 4week period with either a nitric oxide releasing solution (treatment) or saline (control). Exhaled NO, methemoglobin percent (MetHg) and serum nitrites demonstrated biological availability as a result of treatment. Cortisol levels, tissue nitrites, behavior and gross and macroscopic pathology of organs were all normal. Moreover, preliminary in vitro studies using Mannheimia haemolytica, Infectious Bovine Rhinotracheitis, Bovine Parainfluenza-3 and Bovine Respiratory Syncytial Virus, suggest a potential explanation for the previously demonstrated efficacy for BRDc. These data confirm the bioavailability, safety and lack of residual of NO treatment to cattle, along with the bactericidal and virucidal effects.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24434056</pmid><doi>10.1016/j.rvsc.2013.12.012</doi><tpages>10</tpages></addata></record> |
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| ispartof | Research in veterinary science, 2014-04, Vol.96 (2), p.328-337 |
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| subjects | Administration, Intranasal Animals Antibiotics Antimicrobial Bacterial infections Behavior, Animal - drug effects Bovine Respiratory Disease Bovine Respiratory Disease Complex - drug therapy Bovine Respiratory Disease Complex - microbiology Bovine Respiratory Disease Complex - virology Cattle Cytotoxicity Disease Drug dosages Free radicals Herpes viruses Histocytochemistry - veterinary Hydrocortisone - blood Infections Lung - microbiology Lung - virology Mammals Methemoglobin - analysis Mortality Nitric oxide Nitric Oxide - administration & dosage Nitric Oxide - pharmacology Nitric Oxide - therapeutic use Nitrites - blood Nitrogen dioxide Proteins Shipping fever Sustainability Undifferentiated fever Veterinary medicine Viral infections |
| title | Safety, bioavailability and mechanism of action of nitric oxide to control Bovine Respiratory Disease Complex in calves entering a feedlot |
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