Systematic Review and Meta-analysis of the Influence of HER2 Expression and Amplification in Operable Oesophageal Cancer
Introduction The prognostic significance of human epidermal growth factor 2 (HER2) overexpression in patients diagnosed with oesophageal cancer is controversial. We performed a systematic review and meta-analysis to determine the influence of HER2 overexpression and amplification on outcomes in oper...
Gespeichert in:
| Veröffentlicht in: | Journal of gastrointestinal surgery 2012-10, Vol.16 (10), p.1821-1829 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1829 |
|---|---|
| container_issue | 10 |
| container_start_page | 1821 |
| container_title | Journal of gastrointestinal surgery |
| container_volume | 16 |
| creator | Chan, David S. Y. Twine, Christopher P. Lewis, Wyn G. |
| description | Introduction
The prognostic significance of human epidermal growth factor 2 (HER2) overexpression in patients diagnosed with oesophageal cancer is controversial. We performed a systematic review and meta-analysis to determine the influence of HER2 overexpression and amplification on outcomes in operable oesophageal cancer.
Methods
MEDLINE and Embase (January 1990 to November 2011) was searched for translational studies that correlated HER2 expression with survival in operable oesophageal cancer.
Results
Fourteen studies involving 1,464 patients who had undergone potentially curative oesophagectomy for oesophageal cancer [322 (22 %) HER2-positive] were included. Five-year mortality was significantly higher in HER2-positive patients [odds ratio (OR) 1.43, 95 % confidence interval (CI) 1.04 to 1.95,
p
= 0.03]. Analysis related to histological cell type demonstrated significantly higher 5-year mortality in HER2-positive squamous cell carcinoma [OR 2.88, 95 % CI 1.34 to 6.17,
p
= 0.006] and adenocarcinoma [OR 1.91, 95 % CI 1.15 to 3.17,
p
= 0.01] on sensitivity analysis of higher-quality studies.
Conclusion
HER2 overexpression and gene amplification in operable oesophageal cancer was an indicator of poor prognosis. |
| doi_str_mv | 10.1007/s11605-012-1979-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1507439943</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3246432981</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-6504903ef007f115f11498ffcab100ebf8c11adbf6debfd3ed8b3c72eb44cc743</originalsourceid><addsrcrecordid>eNp1kFtLAzEQhYMoVqs_wBcJ-BzNZLO3Ryn1AkrBC_gWstlJu2W7uyZbbf-9qa3iiw9hkplzTpiPkDPgl8B5euUBEh4zDoJBnuZM7JEjyNKIyUQk--HOc2Aijt8G5Nj7OeeQcsgOyUCITEY8k0dk9bz2PS50Xxn6hB8VflLdlPQRe810o-u1rzxtLe1nSO8bWy-xMbhp3I2fBB2vOofeV23z7bpedHVlKxPSQqdq6KRDp4sa6QR92830FHVNRzpEuBNyYHXt8XRXh-T1ZvwyumMPk9v70fUDM1EqepbEXOY8Qhv2tQBxODLPrDW6CAiwsJkB0GVhkzI8ygjLrIhMKrCQ0phURkNysc3tXPu-RN-rebt0YTOvIOZBkOcyCirYqoxrvXdoVeeqhXZrBVxtWKstaxVYqw1rJYLnfJe8LBZY_jp-4AaB2Ap8GDVTdH--_jf1C-NqiuE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1507439943</pqid></control><display><type>article</type><title>Systematic Review and Meta-analysis of the Influence of HER2 Expression and Amplification in Operable Oesophageal Cancer</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Chan, David S. Y. ; Twine, Christopher P. ; Lewis, Wyn G.</creator><creatorcontrib>Chan, David S. Y. ; Twine, Christopher P. ; Lewis, Wyn G.</creatorcontrib><description>Introduction
The prognostic significance of human epidermal growth factor 2 (HER2) overexpression in patients diagnosed with oesophageal cancer is controversial. We performed a systematic review and meta-analysis to determine the influence of HER2 overexpression and amplification on outcomes in operable oesophageal cancer.
Methods
MEDLINE and Embase (January 1990 to November 2011) was searched for translational studies that correlated HER2 expression with survival in operable oesophageal cancer.
Results
Fourteen studies involving 1,464 patients who had undergone potentially curative oesophagectomy for oesophageal cancer [322 (22 %) HER2-positive] were included. Five-year mortality was significantly higher in HER2-positive patients [odds ratio (OR) 1.43, 95 % confidence interval (CI) 1.04 to 1.95,
p
= 0.03]. Analysis related to histological cell type demonstrated significantly higher 5-year mortality in HER2-positive squamous cell carcinoma [OR 2.88, 95 % CI 1.34 to 6.17,
p
= 0.006] and adenocarcinoma [OR 1.91, 95 % CI 1.15 to 3.17,
p
= 0.01] on sensitivity analysis of higher-quality studies.
Conclusion
HER2 overexpression and gene amplification in operable oesophageal cancer was an indicator of poor prognosis.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-012-1979-2</identifier><identifier>PMID: 22843084</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - mortality ; Adenocarcinoma - surgery ; Asymmetry ; Cancer therapies ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - surgery ; Chemotherapy ; Cohort analysis ; Collaboration ; Epidermal growth factor ; Esophageal cancer ; Esophageal Neoplasms - metabolism ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - surgery ; Esophagectomy ; Gastroenterology ; Gene Amplification ; Genes, erbB-2 ; Genetic Markers ; Humans ; Kinases ; Medical prognosis ; Medicine ; Medicine & Public Health ; Meta-analysis ; Mortality ; Odds Ratio ; Original Article ; Patients ; Receptor, ErbB-2 - genetics ; Receptor, ErbB-2 - metabolism ; Sensitivity analysis ; Statistical analysis ; Surgery ; Survival Rate ; Systematic review ; Treatment Outcome</subject><ispartof>Journal of gastrointestinal surgery, 2012-10, Vol.16 (10), p.1821-1829</ispartof><rights>The Society for Surgery of the Alimentary Tract 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-6504903ef007f115f11498ffcab100ebf8c11adbf6debfd3ed8b3c72eb44cc743</citedby><cites>FETCH-LOGICAL-c372t-6504903ef007f115f11498ffcab100ebf8c11adbf6debfd3ed8b3c72eb44cc743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-012-1979-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-012-1979-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22843084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, David S. Y.</creatorcontrib><creatorcontrib>Twine, Christopher P.</creatorcontrib><creatorcontrib>Lewis, Wyn G.</creatorcontrib><title>Systematic Review and Meta-analysis of the Influence of HER2 Expression and Amplification in Operable Oesophageal Cancer</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Introduction
The prognostic significance of human epidermal growth factor 2 (HER2) overexpression in patients diagnosed with oesophageal cancer is controversial. We performed a systematic review and meta-analysis to determine the influence of HER2 overexpression and amplification on outcomes in operable oesophageal cancer.
Methods
MEDLINE and Embase (January 1990 to November 2011) was searched for translational studies that correlated HER2 expression with survival in operable oesophageal cancer.
Results
Fourteen studies involving 1,464 patients who had undergone potentially curative oesophagectomy for oesophageal cancer [322 (22 %) HER2-positive] were included. Five-year mortality was significantly higher in HER2-positive patients [odds ratio (OR) 1.43, 95 % confidence interval (CI) 1.04 to 1.95,
p
= 0.03]. Analysis related to histological cell type demonstrated significantly higher 5-year mortality in HER2-positive squamous cell carcinoma [OR 2.88, 95 % CI 1.34 to 6.17,
p
= 0.006] and adenocarcinoma [OR 1.91, 95 % CI 1.15 to 3.17,
p
= 0.01] on sensitivity analysis of higher-quality studies.
Conclusion
HER2 overexpression and gene amplification in operable oesophageal cancer was an indicator of poor prognosis.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - surgery</subject><subject>Asymmetry</subject><subject>Cancer therapies</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Chemotherapy</subject><subject>Cohort analysis</subject><subject>Collaboration</subject><subject>Epidermal growth factor</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - metabolism</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy</subject><subject>Gastroenterology</subject><subject>Gene Amplification</subject><subject>Genes, erbB-2</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>Kinases</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Mortality</subject><subject>Odds Ratio</subject><subject>Original Article</subject><subject>Patients</subject><subject>Receptor, ErbB-2 - genetics</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Sensitivity analysis</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Systematic review</subject><subject>Treatment Outcome</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kFtLAzEQhYMoVqs_wBcJ-BzNZLO3Ryn1AkrBC_gWstlJu2W7uyZbbf-9qa3iiw9hkplzTpiPkDPgl8B5euUBEh4zDoJBnuZM7JEjyNKIyUQk--HOc2Aijt8G5Nj7OeeQcsgOyUCITEY8k0dk9bz2PS50Xxn6hB8VflLdlPQRe810o-u1rzxtLe1nSO8bWy-xMbhp3I2fBB2vOofeV23z7bpedHVlKxPSQqdq6KRDp4sa6QR92830FHVNRzpEuBNyYHXt8XRXh-T1ZvwyumMPk9v70fUDM1EqepbEXOY8Qhv2tQBxODLPrDW6CAiwsJkB0GVhkzI8ygjLrIhMKrCQ0phURkNysc3tXPu-RN-rebt0YTOvIOZBkOcyCirYqoxrvXdoVeeqhXZrBVxtWKstaxVYqw1rJYLnfJe8LBZY_jp-4AaB2Ap8GDVTdH--_jf1C-NqiuE</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Chan, David S. Y.</creator><creator>Twine, Christopher P.</creator><creator>Lewis, Wyn G.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20121001</creationdate><title>Systematic Review and Meta-analysis of the Influence of HER2 Expression and Amplification in Operable Oesophageal Cancer</title><author>Chan, David S. Y. ; Twine, Christopher P. ; Lewis, Wyn G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-6504903ef007f115f11498ffcab100ebf8c11adbf6debfd3ed8b3c72eb44cc743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - surgery</topic><topic>Asymmetry</topic><topic>Cancer therapies</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Chemotherapy</topic><topic>Cohort analysis</topic><topic>Collaboration</topic><topic>Epidermal growth factor</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - metabolism</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy</topic><topic>Gastroenterology</topic><topic>Gene Amplification</topic><topic>Genes, erbB-2</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>Kinases</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Mortality</topic><topic>Odds Ratio</topic><topic>Original Article</topic><topic>Patients</topic><topic>Receptor, ErbB-2 - genetics</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Sensitivity analysis</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Systematic review</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, David S. Y.</creatorcontrib><creatorcontrib>Twine, Christopher P.</creatorcontrib><creatorcontrib>Lewis, Wyn G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, David S. Y.</au><au>Twine, Christopher P.</au><au>Lewis, Wyn G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systematic Review and Meta-analysis of the Influence of HER2 Expression and Amplification in Operable Oesophageal Cancer</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>16</volume><issue>10</issue><spage>1821</spage><epage>1829</epage><pages>1821-1829</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Introduction
The prognostic significance of human epidermal growth factor 2 (HER2) overexpression in patients diagnosed with oesophageal cancer is controversial. We performed a systematic review and meta-analysis to determine the influence of HER2 overexpression and amplification on outcomes in operable oesophageal cancer.
Methods
MEDLINE and Embase (January 1990 to November 2011) was searched for translational studies that correlated HER2 expression with survival in operable oesophageal cancer.
Results
Fourteen studies involving 1,464 patients who had undergone potentially curative oesophagectomy for oesophageal cancer [322 (22 %) HER2-positive] were included. Five-year mortality was significantly higher in HER2-positive patients [odds ratio (OR) 1.43, 95 % confidence interval (CI) 1.04 to 1.95,
p
= 0.03]. Analysis related to histological cell type demonstrated significantly higher 5-year mortality in HER2-positive squamous cell carcinoma [OR 2.88, 95 % CI 1.34 to 6.17,
p
= 0.006] and adenocarcinoma [OR 1.91, 95 % CI 1.15 to 3.17,
p
= 0.01] on sensitivity analysis of higher-quality studies.
Conclusion
HER2 overexpression and gene amplification in operable oesophageal cancer was an indicator of poor prognosis.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22843084</pmid><doi>10.1007/s11605-012-1979-2</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1091-255X |
| ispartof | Journal of gastrointestinal surgery, 2012-10, Vol.16 (10), p.1821-1829 |
| issn | 1091-255X 1873-4626 |
| language | eng |
| recordid | cdi_proquest_journals_1507439943 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - surgery Asymmetry Cancer therapies Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - surgery Chemotherapy Cohort analysis Collaboration Epidermal growth factor Esophageal cancer Esophageal Neoplasms - metabolism Esophageal Neoplasms - mortality Esophageal Neoplasms - surgery Esophagectomy Gastroenterology Gene Amplification Genes, erbB-2 Genetic Markers Humans Kinases Medical prognosis Medicine Medicine & Public Health Meta-analysis Mortality Odds Ratio Original Article Patients Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Sensitivity analysis Statistical analysis Surgery Survival Rate Systematic review Treatment Outcome |
| title | Systematic Review and Meta-analysis of the Influence of HER2 Expression and Amplification in Operable Oesophageal Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T00%3A56%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Systematic%20Review%20and%20Meta-analysis%20of%20the%20Influence%20of%20HER2%20Expression%20and%20Amplification%20in%20Operable%20Oesophageal%20Cancer&rft.jtitle=Journal%20of%20gastrointestinal%20surgery&rft.au=Chan,%20David%20S.%20Y.&rft.date=2012-10-01&rft.volume=16&rft.issue=10&rft.spage=1821&rft.epage=1829&rft.pages=1821-1829&rft.issn=1091-255X&rft.eissn=1873-4626&rft_id=info:doi/10.1007/s11605-012-1979-2&rft_dat=%3Cproquest_cross%3E3246432981%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1507439943&rft_id=info:pmid/22843084&rfr_iscdi=true |