The neural correlates of placebo effects: a disruption account

The neurocognitive pathways by which placebo effects operate are poorly understood. Positron emission tomography (PET) imaging was used to assess the brain response of patients with chronic abdominal pain (irritable bowel syndrome; IBS) to induced intestinal discomfort both before and after a 3-week...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2004-05, Vol.22 (1), p.447-455
Hauptverfasser: Lieberman, Matthew D, Jarcho, Johanna M, Berman, Steve, Naliboff, Bruce D, Suyenobu, Brandall Y, Mandelkern, Mark, Mayer, Emeran A
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container_issue 1
container_start_page 447
container_title NeuroImage (Orlando, Fla.)
container_volume 22
creator Lieberman, Matthew D
Jarcho, Johanna M
Berman, Steve
Naliboff, Bruce D
Suyenobu, Brandall Y
Mandelkern, Mark
Mayer, Emeran A
description The neurocognitive pathways by which placebo effects operate are poorly understood. Positron emission tomography (PET) imaging was used to assess the brain response of patients with chronic abdominal pain (irritable bowel syndrome; IBS) to induced intestinal discomfort both before and after a 3-week placebo regimen. A daily symptom diary was used to measure symptom improvement. Increases in right ventrolateral prefrontal cortex (RVLPFC) activity from pre- to post-placebo predicted self-reported symptom improvement, and this relationship was mediated by changes in dorsal anterior cingulate (dACC), typically associated with pain unpleasantness. These results are consistent with disruption theory [Lieberman, M.D., 2003. Reflective and reflexive judgment processes: a social cognitive neuroscience approach. In: Forgas, J.P., Williams, K.R., von Hippel, W. (Eds.), Social Judgments: Explicit and Implicit Processes. Cambridge Univ. Press, New York, pp. 44–67], which proposes that activation of prefrontal regions associated with thinking about negative affect can diminish dACC and amygdala reactivity to negative affect stimuli. This is the first study to identify a neural pathway from a region of the brain associated with placebos and affective thought to a region closely linked to the placebo-related outcome of diminished pain unpleasantness.
doi_str_mv 10.1016/j.neuroimage.2004.01.037
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subjects Adult
Behavior
Catheterization
Cognition - physiology
Colon - physiology
Disruption
Electrocardiography
Female
Galvanic Skin Response - physiology
Gyrus Cinguli - diagnostic imaging
Gyrus Cinguli - physiology
Humans
Image Processing, Computer-Assisted
Male
Medical imaging
Middle Aged
Nerve Net - diagnostic imaging
Nerve Net - physiology
Neural correlates
Physical Stimulation
Placebo Effect
Placebo effects
Prefrontal Cortex - diagnostic imaging
Prefrontal Cortex - physiology
Theory
Tomography, Emission-Computed
title The neural correlates of placebo effects: a disruption account
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