The neural correlates of placebo effects: a disruption account
The neurocognitive pathways by which placebo effects operate are poorly understood. Positron emission tomography (PET) imaging was used to assess the brain response of patients with chronic abdominal pain (irritable bowel syndrome; IBS) to induced intestinal discomfort both before and after a 3-week...
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description | The neurocognitive pathways by which placebo effects operate are poorly understood. Positron emission tomography (PET) imaging was used to assess the brain response of patients with chronic abdominal pain (irritable bowel syndrome; IBS) to induced intestinal discomfort both before and after a 3-week placebo regimen. A daily symptom diary was used to measure symptom improvement. Increases in right ventrolateral prefrontal cortex (RVLPFC) activity from pre- to post-placebo predicted self-reported symptom improvement, and this relationship was mediated by changes in dorsal anterior cingulate (dACC), typically associated with pain unpleasantness. These results are consistent with
disruption theory [Lieberman, M.D., 2003. Reflective and reflexive judgment processes: a social cognitive neuroscience approach. In: Forgas, J.P., Williams, K.R., von Hippel, W. (Eds.), Social Judgments: Explicit and Implicit Processes. Cambridge Univ. Press, New York, pp. 44–67], which proposes that activation of prefrontal regions associated with thinking about negative affect can diminish dACC and amygdala reactivity to negative affect stimuli. This is the first study to identify a neural pathway from a region of the brain associated with placebos and affective thought to a region closely linked to the placebo-related outcome of diminished pain unpleasantness. |
doi_str_mv | 10.1016/j.neuroimage.2004.01.037 |
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disruption theory [Lieberman, M.D., 2003. Reflective and reflexive judgment processes: a social cognitive neuroscience approach. In: Forgas, J.P., Williams, K.R., von Hippel, W. (Eds.), Social Judgments: Explicit and Implicit Processes. Cambridge Univ. Press, New York, pp. 44–67], which proposes that activation of prefrontal regions associated with thinking about negative affect can diminish dACC and amygdala reactivity to negative affect stimuli. This is the first study to identify a neural pathway from a region of the brain associated with placebos and affective thought to a region closely linked to the placebo-related outcome of diminished pain unpleasantness.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2004.01.037</identifier><identifier>PMID: 15110038</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Behavior ; Catheterization ; Cognition - physiology ; Colon - physiology ; Disruption ; Electrocardiography ; Female ; Galvanic Skin Response - physiology ; Gyrus Cinguli - diagnostic imaging ; Gyrus Cinguli - physiology ; Humans ; Image Processing, Computer-Assisted ; Male ; Medical imaging ; Middle Aged ; Nerve Net - diagnostic imaging ; Nerve Net - physiology ; Neural correlates ; Physical Stimulation ; Placebo Effect ; Placebo effects ; Prefrontal Cortex - diagnostic imaging ; Prefrontal Cortex - physiology ; Theory ; Tomography, Emission-Computed</subject><ispartof>NeuroImage (Orlando, Fla.), 2004-05, Vol.22 (1), p.447-455</ispartof><rights>2004 Elsevier Inc.</rights><rights>Copyright Elsevier Limited May 1, 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-e55e0ff121925959bc6dc8e3baa6e9705222fbf40a4d266caec242b8af980e523</citedby><cites>FETCH-LOGICAL-c483t-e55e0ff121925959bc6dc8e3baa6e9705222fbf40a4d266caec242b8af980e523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1053811904000527$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15110038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lieberman, Matthew D</creatorcontrib><creatorcontrib>Jarcho, Johanna M</creatorcontrib><creatorcontrib>Berman, Steve</creatorcontrib><creatorcontrib>Naliboff, Bruce D</creatorcontrib><creatorcontrib>Suyenobu, Brandall Y</creatorcontrib><creatorcontrib>Mandelkern, Mark</creatorcontrib><creatorcontrib>Mayer, Emeran A</creatorcontrib><title>The neural correlates of placebo effects: a disruption account</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>The neurocognitive pathways by which placebo effects operate are poorly understood. Positron emission tomography (PET) imaging was used to assess the brain response of patients with chronic abdominal pain (irritable bowel syndrome; IBS) to induced intestinal discomfort both before and after a 3-week placebo regimen. A daily symptom diary was used to measure symptom improvement. Increases in right ventrolateral prefrontal cortex (RVLPFC) activity from pre- to post-placebo predicted self-reported symptom improvement, and this relationship was mediated by changes in dorsal anterior cingulate (dACC), typically associated with pain unpleasantness. These results are consistent with
disruption theory [Lieberman, M.D., 2003. Reflective and reflexive judgment processes: a social cognitive neuroscience approach. In: Forgas, J.P., Williams, K.R., von Hippel, W. (Eds.), Social Judgments: Explicit and Implicit Processes. Cambridge Univ. Press, New York, pp. 44–67], which proposes that activation of prefrontal regions associated with thinking about negative affect can diminish dACC and amygdala reactivity to negative affect stimuli. This is the first study to identify a neural pathway from a region of the brain associated with placebos and affective thought to a region closely linked to the placebo-related outcome of diminished pain unpleasantness.</description><subject>Adult</subject><subject>Behavior</subject><subject>Catheterization</subject><subject>Cognition - physiology</subject><subject>Colon - physiology</subject><subject>Disruption</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Galvanic Skin Response - physiology</subject><subject>Gyrus Cinguli - diagnostic imaging</subject><subject>Gyrus Cinguli - physiology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Nerve Net - diagnostic imaging</subject><subject>Nerve Net - physiology</subject><subject>Neural correlates</subject><subject>Physical Stimulation</subject><subject>Placebo Effect</subject><subject>Placebo effects</subject><subject>Prefrontal Cortex - diagnostic imaging</subject><subject>Prefrontal Cortex - physiology</subject><subject>Theory</subject><subject>Tomography, Emission-Computed</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkF1LwzAUhoMobk7_ggS8bj1Jm67xQtDhFwy8mdchTU-0ZWtq0gr-e1M22KVX51y8H7wPIZRByoAVt23a4ehds9OfmHKAPAWWQrY8IXMGUiRSLPnp9IssKRmTM3IRQgsAkuXlOZkxwRhAVs7J_eYL6RSmt9Q473GrBwzUWdpvtcHKUbQWzRDuqKZ1E_zYD43rqDbGjd1wSc6s3ga8OtwF-Xh-2qxek_X7y9vqYZ2YvMyGBIVAsJZxJrmQQlamqE2JWaV1gXIJgnNuK5uDzmteFEaj4TmvSm1lCSh4tiA3-9zeu-8Rw6BaN_ouViomoCji6AKiqtyrjHcheLSq95GR_1UM1AROteoITk3gFDAVwUXr9aFgrHZYH40HUlHwuBdgnPnToFfBNNgZrBsf-ajaNf-3_AHYJoOr</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Lieberman, Matthew D</creator><creator>Jarcho, Johanna M</creator><creator>Berman, Steve</creator><creator>Naliboff, Bruce D</creator><creator>Suyenobu, Brandall Y</creator><creator>Mandelkern, Mark</creator><creator>Mayer, Emeran A</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20040501</creationdate><title>The neural correlates of placebo effects: a disruption account</title><author>Lieberman, Matthew D ; 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Positron emission tomography (PET) imaging was used to assess the brain response of patients with chronic abdominal pain (irritable bowel syndrome; IBS) to induced intestinal discomfort both before and after a 3-week placebo regimen. A daily symptom diary was used to measure symptom improvement. Increases in right ventrolateral prefrontal cortex (RVLPFC) activity from pre- to post-placebo predicted self-reported symptom improvement, and this relationship was mediated by changes in dorsal anterior cingulate (dACC), typically associated with pain unpleasantness. These results are consistent with
disruption theory [Lieberman, M.D., 2003. Reflective and reflexive judgment processes: a social cognitive neuroscience approach. In: Forgas, J.P., Williams, K.R., von Hippel, W. (Eds.), Social Judgments: Explicit and Implicit Processes. Cambridge Univ. Press, New York, pp. 44–67], which proposes that activation of prefrontal regions associated with thinking about negative affect can diminish dACC and amygdala reactivity to negative affect stimuli. This is the first study to identify a neural pathway from a region of the brain associated with placebos and affective thought to a region closely linked to the placebo-related outcome of diminished pain unpleasantness.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15110038</pmid><doi>10.1016/j.neuroimage.2004.01.037</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Behavior Catheterization Cognition - physiology Colon - physiology Disruption Electrocardiography Female Galvanic Skin Response - physiology Gyrus Cinguli - diagnostic imaging Gyrus Cinguli - physiology Humans Image Processing, Computer-Assisted Male Medical imaging Middle Aged Nerve Net - diagnostic imaging Nerve Net - physiology Neural correlates Physical Stimulation Placebo Effect Placebo effects Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - physiology Theory Tomography, Emission-Computed |
title | The neural correlates of placebo effects: a disruption account |
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