The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis: in vivo study by high-resolution magnetic resonance imaging

We sought to investigate the anti-atherogenic effects of a selective peroxisomal proliferator-activated receptor-gamma (PPAR-gamma) agonist and simvastatin, as well as their combination, over time, in a rabbit model of experimental atherosclerosis. The PPARs are nuclear transcription factors that co...

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Veröffentlicht in:	Journal of the American College of Cardiology 2004-02, Vol.43 (3), p.464
Hauptverfasser:	Corti, Roberto, Osende, Julio I, Fallon, John T, Fuster, Valentin, Mizsei, Gabor, Jneid, Hani, Wright, Samuel D, Chaplin, William F, Badimon, Juan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - therapeutic use Arteriosclerosis - diagnosis Arteriosclerosis - drug therapy Atherosclerosis Cardiology Cholesterol Diet Drug Synergism Drug therapy Gene expression Histology Hypolipidemic Agents - therapeutic use Ligands Lipids Magnetic Resonance Imaging Male Models, Animal NMR Nuclear magnetic resonance Plasma Rabbits Receptors, Cytoplasmic and Nuclear - agonists Remission Induction Simvastatin - therapeutic use Transcription Factors - agonists
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