Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II

We investigated if endothelin (ET)-1 and the renin-angiotensin-aldosterone system play a role in cardiac fibrosis. Angiotensin II (Ang II) can induce cardiac fibrosis, but the underlying mechanisms are incompletely understood. Four-week-old transgenic (mRen2)27 rat (TGRen2) received for four weeks a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American College of Cardiology 2003-02, Vol.41 (4), p.666-673
Hauptverfasser:	Seccia, Teresa M, Belloni, Anna S, Kreutz, Reinhold, Paul, Martin, Nussdorfer, Gastone G, Pessina, Achille C, Rossi, Gian Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - adverse effects Animals Animals, Genetically Modified Antihypertensive Agents - pharmacology Arterial hypertension. Arterial hypotension Biological and medical sciences Biphenyl Compounds - pharmacology Blood and lymphatic vessels Bosentan Cardiology Cardiology. Vascular system Cardiomyopathies - etiology Cardiomyopathies - pathology Cardiomyopathies - physiopathology Collagen Dansyl Compounds - pharmacology Disease Models, Animal Endothelin-1 - drug effects Endothelin-1 - physiology Enzymes Experimental diseases Fibrosis - etiology Fibrosis - pathology Fibrosis - physiopathology Gene expression Heart Hypertension Hypertension - chemically induced Hypertension - complications Hypertension - physiopathology Irbesartan Male Medical sciences Plasma Rats Receptor, Angiotensin, Type 1 Receptors, Angiotensin - drug effects Receptors, Angiotensin - physiology Receptors, Cell Surface - drug effects Receptors, Cell Surface - physiology Rodents Sulfonamides - pharmacology Tetrazoles - pharmacology Time Factors Vasoconstrictor Agents - adverse effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!